Kidney International Reports, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Natural Product Communications, Год журнала: 2025, Номер 20(2)
Опубликована: Фев. 1, 2025
Diabetic nephropathy (DN) is the leading cause of uremia and clinical mortality, characterized by progressive deterioration kidney structure function due to prolonged exposure hyperglycemia. This condition often necessitates renal replacement therapy for patients with end-stage-renal-disease (ESRD). Consequently, early detection, diagnosis, treatment DN are crucial mitigate disease progression, enhance patient outcomes, maintain a good quality life. Exploring relevant biomarkers diagnosis holds significant importance. In recent years, numerous researchers have identified various novel associated diabetic nephropathy, which critical predicting both onset progression disease. article aims provide comprehensive overview related DN.
Язык: Английский
Процитировано
0
World Journal of Diabetes, Год журнала: 2025, Номер 16(4)
Опубликована: Фев. 28, 2025
Diabetic nephropathy (DN) is a well-known microvascular complication in patients with diabetes mellitus, which characterized by the accumulation of extracellular matrix glomerular and tubulointerstitial compartments, along hyalinization intrarenal vasculature. DN has recently emerged as leading cause chronic end-stage renal disease. While pathobiology other diabetic complications, such retinopathy, largely understood reasonable therapeutic options, mechanisms management strategies for remain incompletely elucidated. In this editorial, we comment on article Liu et al, focusing underlying detrimental impact β-arrestin-2 kidneys context DN. The authors suggest that inhibiting could alleviate damage through suppressing apoptosis endothelial cells (GENCs), highlighting promising target study proposed triggers endoplasmic reticulum (ER) stress via ATF6 signaling pathway, thereby promoting GENC exacerbating progression. Given novel crucial role ER stress-related DN, it imperative to further explore β-arrestin-2, its roles potential implications
Язык: Английский
Процитировано
0
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Июль 4, 2024
Objectives To evaluate the efficacy and safety of non-steroid mineralocorticoid receptor antagonists (ns-MRAs) sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with diabetic kidney disease (DKD). Methods Systematic literature searches were performed using PubMed, Embase Web Science encompassing inception until January 20, 2024. Randomized control trials (RCTs) comparing ns-MRAs SGLT2is DKD selected. The outcomes interest included kidney-specific composite outcome, cardiovascular (CV)-specific end-stage (ESKD), overall mortality. We also investigated outcomes, including acute injury (AKI) hyperkalemia. Results A total 10 randomized clinical 35,786 applying various treatments included. (SUCRA 99.84%) have potential superiority protection. (RR 1.41, 95%CI 1.26 to 1.57) 1.17, 95% CI 1.08 1.27) associated significantly lower outcome than placebo. Regarding reduction CV-specific ESKD, 91.61%; 91.38%) playing cardiorenal Concerning 1.27, 1.09 1.43) ESKD 1.43, 1.20 1.72), reduced risks compared mortality, 83.03%) postponing comparable effects placebo reduce risk mortality For AKI reduction, 63.58%) superiority. 1.24, 1.05 1.46) AKI. hyperkalemia 93.12%) nsMRAs 1.24 0.39 3.72) 1.01 0.40 3.02) did not show significant benefit Conclusion may be recommended as a treatment regimen for maximizing protection, minimal DKD. review registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42023458613.
Язык: Английский
Процитировано
3
Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 119158 - 119158
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
2
American Journal of Clinical and Experimental Medicine, Год журнала: 2024, Номер 12(3), С. 28 - 44
Опубликована: Июль 29, 2024
Rhubarb has been found to have a certain protective effect on improving the kidney function. However, specific mechanism is still unclear. In this study, network pharmacology, molecular docking spontaneous binding technology and biology experiments were used verify of rhubarb its active ingredients in treatment DKD. A total 10 compounds 121 (larger than average) target proteins collected. The with higher degree value screened by PPI according as follows: AKT1, STAT3, EGFR, NFKB1, SRC, etc. GO KEGG enrichment analysis suggest that therapy for DKD mainly involves Pathways cancer, Prostate Proteoglycans Chemokine signaling pathway, PI3K-Akt PD-L1 expression PD-1 checkpoint pathway EGFR tyrosine kinase inhibitor resistance so on. Furthermore, results hydrogen bonding, salt bridge hydrophobic interactions contribute compound protein. Experimental verification shows aloe emodin affect pyroptosis diabetic disease regulating STAT3/Caspase11 axis. conclusion, study comprehensively elaborated compounds, potential targets experimental mechanisms provide basic theory clinical
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Дек. 9, 2024
Nephrotic syndrome has a significant impact on global health, often leading to cardiovascular disease and high mortality due limited effective treatments. This study investigates the efficacy of Shensu IV in puromycin aminonucleoside (PAN)-induced rat model nephropathy.
Язык: Английский
Процитировано
0
Kidney International Reports, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0