The Role of Ferroptosis and Cuproptosis in Tuberculosis Pathogenesis: Implications for Therapeutic Strategies
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(2), С. 99 - 99
Опубликована: Фев. 5, 2025
Tuberculosis
(TB)
caused
by
Mycobacterium
tuberculosis
(M.tb)
remains
a
global
health
crisis,
with
over
10
million
people
affected
annually.
Despite
advancements
in
treatment,
M.tb
has
developed
mechanisms
to
evade
host
immune
responses,
complicating
efforts
eradicate
the
disease.
Two
emerging
cell
death
pathways,
ferroptosis
and
cuproptosis,
have
been
linked
TB
pathogenesis.
Ferroptosis,
an
iron-dependent
form
of
death,
is
driven
lipid
peroxidation
reactive
oxygen
species
(ROS)
accumulation.
This
process
can
limit
replication
depleting
intracellular
iron
inducing
macrophage
necrosis.
However,
excessive
may
lead
tissue
damage
aid
bacterial
dissemination.
Cuproptosis,
triggered
copper
accumulation,
disrupts
mitochondrial
metabolism,
leading
protein
aggregation
death.
exploits
both
metabolism
survive
within
macrophages,
manipulating
these
processes
resist
oxidative
stress
responses.
review
examines
roles
cuproptosis
TB,
discussing
how
manipulates
pathways
for
survival.
While
therapeutic
strategies
targeting
processes,
such
as
inducers
(Erastin,
RSL3)
inhibitors
(Ferrostatin-1)
ionophores
(Disulfiram,
Elesclomol)
chelators,
show
promise,
limited
understanding
potential
off-target
effects
significant
challenge.
Further
exploration
provide
insights
into
development
targeted
therapies
aimed
at
controlling
infection
while
minimizing
damage.
By
elucidating
complex
interactions
between
ferroptosis,
future
could
better
address
resistance
improve
clinical
outcomes.
Язык: Английский
Research Progress on the Regulatory Role of Different Cell Death Pathways in Metabolic-dysfunction-associated Steatotic Liver Disease
Clinics and Research in Hepatology and Gastroenterology,
Год журнала:
2025,
Номер
49(6), С. 102578 - 102578
Опубликована: Апрель 2, 2025
Язык: Английский
Emerging roles of cuproptosis in liver diseases
Digestive and Liver Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Intracellular
copper
levels
should
be
maintained
within
a
controlled
range
to
obtain
homeostasis.
Cuproptosis,
newly
discovered
form
of
cell
death,
occurs
when
excessive
ions
bind
the
lipoylated
enzymes
in
tricarboxylic
acid
cycle,
which
leads
protein
aggregation,
proteotoxic
stress,
and
ultimately
death.
Herein,
we
summarize
current
knowledge
regarding
metabolism,
discovery
molecular
mechanism
cuproptosis.
In
addition,
discuss
implications
cuproptosis
pathogenesis
various
liver
diseases,
including
hepatocellular
carcinoma
(HCC),
Wilson
disease
(WD),
metabolic-associated
fatty
(MAFLD),
fibrosis,
hepatic
ischemia-reperfusion
injury
(HIRI)
drug-induced
(DILI).
Understanding
can
not
only
provide
deeper
insights
into
diseases
but
also
open
up
new
avenues
for
development
targeted
therapies.
Язык: Английский