Productivity Losses due to Health Problems Arising from COVID-19 Pandemic: A Systematic Review of Population-Level Studies Worldwide

Applied Health Economics and Health Policy, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Язык: Английский

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Excess mortality and years of life lost from 2020 to 2023 in France: a cohort study of the overall impact of the COVID-19 pandemic on mortality

BMJ Public Health, Год журнала: 2025, Номер 3(1), С. e001836 - e001836

Опубликована: Янв. 1, 2025

Excess mortality has been frequently used worldwide for summarising the COVID-19 pandemic-related burden. Estimates France years 2020-2022 vary substantially from one report to another, and year 2023 is poorly documented. The present study assessed level of excess that occurred in between 2020 together with corresponding life lost (YLL), order provide a reliable, detailed comprehensive description overall impact pandemic. This open cohort whole French population analysed 8 451 372 death occurrences reported 2010-2023. A Poisson regression model was trained 2010-2019 determining age-specific sex-specific evolution trends before pandemic period. These were then estimating during period (years 2020-2023). expectancies persons YLL. From 2023, number deaths (mean (95% CI) (percentage change versus expected mortality)) was, respectively, 49 541 (48 467; 50 616) (+8.0%), 42 667 (41 410; 43 909) (+6.9%), 53 129 (51 696; 54 551) (+8.5%), 17 355 (15 760; 18 917) (+2.8%). Corresponding YLL 512 753 (496 029; 529 633), 583 580 (564 137; 602 747), 663 588 (641 863; 685 723), 312 133 (288 051; 335 929). Individuals younger than 60 old accounted 17% 2020, 26% 2021, 32% 2022 50% 2023. Men more affected women by both highlights long-lasting on France, four consecutive growing people under 60, particularly men, suggesting lasting profound disruption healthcare system.

Язык: Английский

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What Really Happened During the Massive SARS-CoV-2 Omicron Wave in China?

JAMA Internal Medicine, Год журнала: 2023, Номер 183(7), С. 633 - 633

Опубликована: Май 15, 2023

This Viewpoint discusses reports from China after its zero COVID-19 policy ended in December 2022.

Язык: Английский

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Variability in excess deaths across countries with different vulnerability during 2020–2023

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(49)

Опубликована: Ноя. 29, 2023

Excess deaths provide total impact estimates of major crises, such as the COVID-19 pandemic. We evaluated excess death trajectories across countries with accurate registration and population age structure data assessed relationships vulnerability indicators. Using Human Mortality Database on 34 countries, were calculated for 2020–2023 (to week 29, 2023) using 2017–2019 reference, adjustment 5 strata. Countries divided into less more vulnerable; latter had per capita nominal GDP < $30,000, Gini > 0.35 income inequality and/or at least ≥2.5% their living in poverty. (as proportion expected deaths, p%) inversely correlated ( r = −0.60), poverty 0.66), modestly 0.45). Incidence rate ratio was 1.062 (95% CI, 1.038–1.087) versus vulnerable countries. started deviating two groups after first wave. Between-country heterogeneity diminished gradually within each group. Less mean p% −0.8% 0.4% 0–64 >65-y-old More 7.0% 7.2%, respectively. Lower rates seen children 0–14 y during prepandemic years. While pandemic hit some earlier than others, country dominated eventually cumulative impact. Half analyzed witnessed no substantial levels, while others suffered tolls.

Язык: Английский

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Assessing COVID-19 Mortality in Serbia’s Capital: Model-Based Analysis of Excess Deaths

JMIR Public Health and Surveillance, Год журнала: 2025, Номер 11, С. e56877 - e56877

Опубликована: Апрель 17, 2025

Abstract Background Concerns have been raised about discrepancies in COVID-19 mortality data, particularly between preliminary and final datasets of vital statistics Serbia. In the original dataset, released daily during ongoing pandemic, there was an underestimation deaths contrast to those reported subsequently yearly dataset statistics. Objective This study aimed assess accuracy justify its use further analyses. addition, we quantified relative impact on death rate Serbian capital’s population. process, explore whether any evidence cause-of-death misattribution existed published datasets. Methods Data were sourced from electronic databases Statistical Office Republic The included recorded causes all citizens currently living territory Belgrade, capital Serbia, 2015 2021. Standardization modeling techniques utilized quantify direct estimate excess deaths. To account for year-to-year trends, used a mixed-effects hierarchical Poisson generalized linear regression model predict 2020 fitted data observed 2019 generate predictions Actual rates then compared obtained estimates. Results total number deaths, calculated estimates, 3175 (99% CI 1715-4094) 8321 6975-9197) ratio estimated 1.07. increase 2021 12.93% 15.74%-17.33%) 39.32% 35.91%-39.32%) expected values, respectively. Those aged 0‐19 years experienced average decrease 22.43% 23.71% 2021, For up 39 years, slight (4.72%) 2020. However, even 20‐39 had 32.95%. people 60‐79 16.95% 38.50% >80 at 11.50% 34.14% model-predicted matched non-COVID-19 Belgrade. concordance predicted provides that did not occur Conclusions finalized Belgrade can be safely analysis. significant with most attributable SARS-CoV-2. increased other than seem misplaced as their appears negligible.

Язык: Английский

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Post-pandemic excess mortality of COVID-19 in Hong Kong: a retrospective study

The Lancet Regional Health - Western Pacific, Год журнала: 2025, Номер 58, С. 101554 - 101554

Опубликована: Апрель 23, 2025

Язык: Английский

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Estimating excess mortality in high-income countries during the COVID-19 pandemic

Journal of the Royal Statistical Society Series A (Statistics in Society), Год журнала: 2024, Номер unknown

Опубликована: Апрель 2, 2024

Abstract Quantifying the number of deaths caused by COVID-19 crisis has been an ongoing challenge for scientists, and no golden standard to do so yet established. We propose a principled approach calculate age-adjusted yearly excess mortality apply it obtain estimates uncertainty bounds 30 countries with publicly available data. The results uncover considerable variation in pandemic outcomes across different countries. further compare our findings existing published other major scientific outlets, highlighting importance proper age adjustment unbiased figures.

Язык: Английский

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COVID-19-Related Age Profiles for SARS-CoV-2 Variants in England and Wales and States of the USA (2020 to 2022): Impact on All-Cause Mortality

Infectious Disease Reports, Год журнала: 2023, Номер 15(5), С. 600 - 634

Опубликована: Окт. 8, 2023

Since 2020, COVID-19 has caused serious mortality around the world. Given ambiguity in establishing as direct cause of death, we first investigate effects age and sex on all-cause during 2020 2021 England Wales. infectious agents have their own unique profile for use a 9-year time series several different methods to adjust single-year-of-age deaths Wales 2019 (the pre-COVID-19 base year) pathogen-neutral baseline. This adjusted year is then used confirm widely reported higher males most ages above 43 both 2021. During (+COVID-19 but no vaccination), male female population-adjusted significantly increased 35. A significant reduction among females aged 75+ could be demonstrated widespread vaccination period; however, below 75 progressively increased. finding arises from mix coverage year-of-age profiles SARS-CoV-2 variants. In addition, specific puberty were demonstrated, where had than males. There evidence that year-of-birth cohorts may also involved, indicating immune priming pathogen outbreaks past led lower some birth cohorts. To specifically identify variants 2023, employ proportion total at each are potentially due or ‘with’ COVID-19. The original Wuhan strain Alpha variant show somewhat limited divergence profile, with shifting moderately 84. Delta targeted individuals 65. Omicron showed overall mortality, markedly relative 65, steeply increasing maximum 100 years age. similar can seen age-banded US states, although they slightly obscured by using bands rather single However, data shows greatly dependent COVID variant. Deaths assessed ‘due to’ (as opposed ‘involving’ COVID-19) especially overestimated change mortality. arose by-product an increase testing capacity late 2020. Potential structure–function mechanisms age-specificity discussed, along potential roles small noncoding RNAs (miRNAs). Using England, it possible unvaccinated do indeed death alters shape manner age, sex, question posed whether vaccines based carry profile.

Язык: Английский

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Variability in excess deaths across countries with different vulnerability during 2020-2023

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Апрель 26, 2023

Excess deaths provide total impact estimates of major crises, such as the COVID-19 pandemic. We evaluated excess death's trajectories during 2020-2023 across countries with accurate death registration and population age structure data; assessed relationships economic indicators vulnerability. Using Human Mortality Database on 34 countries, were calculated for (to week 29, 2023) using 2017-2019 reference, weekly expected calculations adjustment 5 strata. Countries divided into less more vulnerable; latter had per capita nominal GDP<$30,000, Gini>0.35 income inequality and/or at least 2.5% their living in poverty. (as proportion deaths, p%) inversely correlated GDP (r=-0.60), poverty (r=0.66) modestly (r=0.45). Incidence rate ratio was 1.06 (95% confidence interval, 1.04-1.08) versus vulnerable countries. started deviating two groups after first wave. Between-country heterogeneity diminished over time within each groups. Less mean p%=-0.8% 0.4% 0-64 >65 year-old strata while p%=7.0% 7.2%, respectively. Usually lower rates seen children 0-14 years old pre-pandemic years. While pandemic hit some earlier than others, country vulnerability dominated eventually cumulative impact. Half analyzed witnessed no substantial levels, other half suffered tolls.

Язык: Английский

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Global estimates of lives and life-years saved by COVID-19 vaccination during 2020-2024

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

ABSTRACT Estimating global lives and life-years saved is important to put into perspective the benefits of COVID-19 vaccination. Prior studies have focused mainly on pre-Omicron period or only specific regions, lack crucial life-year calculations, often depend strong modeling assumptions with unaccounted uncertainty. We aimed calculate by vaccination worldwide from onset campaigns until October 2024. considered different strata according age; community-dwelling long-term care residence status; Omicron periods; before after a SARS-CoV-2 infection. In main analysis, 2.533 million deaths were averted. Eighty-two percent among people vaccinated any infection, 57% in period, 90% pertained 60 years above. Sensitivity analyses suggested 1.4 4.0 saved. Some sensitivity showed preponderance benefit during period. estimated 14.8 (sensitivity range, 7.4-23.6 life-years). Most (76%) over old, but residents contributed 2% total. Children adolescents (0.01% 0.1% saved) young adults 20-29 old (0.07% 0.3% had very small contributions total benefit. Based number assumptions, these estimates are substantially more conservative than previous calculations focusing mostly first year vaccination, they still undeniably demonstrate major overall 2020-2024. The vast majority was secured for portion elderly minority population.

Язык: Английский

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