Shen-fu Injection Modulates HIF- 1α/BNIP3-Mediated Mitophagy to Alleviate Myocardial Ischemia–Reperfusion Injury

Cardiovascular Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Язык: Английский

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Mitochondria for Cardiovascular Therapy: A Deep Dive into Drug Targets and Therapeutic Approaches

Current Pharmacology Reports, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 4, 2025

Язык: Английский

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Roles of Mitochondrial Quality Control in the Pathogenesis of Atherosclerosis

Cardiovascular Innovations and Applications, Год журнала: 2025, Номер 10(1)

Опубликована: Янв. 1, 2025

Mitochondrial quality control (MQC) mechanisms – including biogenesis, dynamics, mitophagy, proteostasis, the unfolded protein response, and mitochondrial-derived vesicles play critical roles in development of atherosclerosis. Dysregulation these processes can lead to mitochondrial dysfunction, subsequently initiation a pathological cascade characterized by oxidative stress, chronic inflammation, accumulation lipids within arterial walls. Specifically, ROS overproduction redox state imbalance are key molecular aspects that exacerbate damage, create self-perpetuating cycle cellular injury disease progression. Emerging therapeutic strategies targeting modulation MQC have promise attenuating atherosclerotic progression restoring balance fusion fission enhancing clearance damaged mitochondria, improving homeostasis. Advancing understanding regulators interaction networks pathways might facilitate precision-targeted therapies. However, substantial challenges persist translating insights into clinical applications. This review explores relationship between atherosclerosis, focusing on associated potential avenues for intervention.

Язык: Английский

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Macrophage Notch1 drives septic cardiac dysfunction by impairing mitophagy and promoting NLRP3 activation

Biology Direct, Год журнала: 2025, Номер 20(1)

Опубликована: Май 26, 2025

Sepsis is a life-threatening condition with limited therapeutic options, characterized as excessive systemic inflammation and multiple organ failure. Macrophages play critical roles in sepsis pathogenesis. Although numerous studies support the role of Notch signaling most inflammatory diseases, function Notch1 macrophages activation its underlying molecular mechanism during has not been fully elucidated. We evaluated expression lipopolysaccharide (LPS)-induced model septic cardiac dysfunction. Using macrophage-specific knockout mice (NOTCH1ΔMyelo) conjunction AAV-F4/80-mediated NICD1 overexpression, we investigated impact on injury. LPS-stimulated bone marrow-derived (BMDMs) were analyzed by flow cytometry ELISA to assess mitochondrial damage inflammasome activation. Mitophagy flux related protein levels quantified, mitophagy inhibitor was applied further delineate Notch1's vivo role. Downstream targets identified validated via ChIP-qPCR luciferase reporter assays. Intraperitoneal injection LPS markedly impaired function, increased macrophage infiltration, elevated compared PBS-treated controls. inversely correlated performance LPS-treated mice. Notably, deletion significantly improved whereas overexpression worsened LPS-induced NOTCH1ΔMyelo showed reduced diminished NLRP3-dependent caspase-1. Moreover, induced mitophagy, an effect that enhanced knockout. Mechanistically, ChIP-seq qPCR analyses revealed upregulates Mst1 transcription. Furthermore, counteracted Notch1-deficient macrophages, resulting reactive oxygen species production, cytokine secretion, caspase-1 prolonged stimulation. Our study uncovers novel for exacerbating dysfunction suppressing macrophages. These findings suggest targeting may offer promising strategy mitigate sepsis-induced restoring proper mitophagy.

Язык: Английский

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Lifestyle and Pharmacological Interventions to Prevent Anthracycline-Related Cardiotoxicity in Cancer Patients

Journal of Cardiovascular Development and Disease, Год журнала: 2025, Номер 12(6), С. 212 - 212

Опубликована: Июнь 4, 2025

Anthracyclines remain a cornerstone of cancer therapy but are associated with significant risk cardiotoxicity, which can lead to overt heart failure. The is modulated by cumulative dose, pre-existing cardiovascular disease, and patient-specific factors. As survival improves, the long-term consequences anthracycline exposure have become growing concern, underscoring need for effective preventive strategies. This narrative review examines lifestyle pharmacological interventions aimed at mitigating anthracycline-induced cardiotoxicity. Evidence suggests that structured exercise programs antioxidant-rich diets may enhance resilience, while beta-blockers, renin-angiotensin system inhibitors, dexrazoxane central options. Emerging therapies, including sodium-glucose co-transporter 2 inhibitors sacubitril/valsartan, show promise require further investigation. A comprehensive approach integrates modifications strategies within multidisciplinary cardio-oncology framework provide optimal protection, improving outcomes in patients receiving anthracyclines.

Язык: Английский

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The Role of Endothelial Cell Mitophagy in Age-Related Cardiovascular Diseases

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

Aging is a major risk factor for cardiovascular diseases (CVD), and mitochondrial autophagy impairment considered significant physiological change associated with aging. Endothelial cells play crucial role in maintaining vascular homeostasis function, participating various processes such as regulating tone, coagulation, angiogenesis, inflammatory responses. As aging progresses, endothelial worsens, leading to the development of numerous diseases. Therefore, vital preventing treating age-related However, there currently lack systematic reviews this area. To address gap, we have written review provide new research therapeutic strategies managing

Язык: Английский

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Mitophagy related diagnostic biomarkers for coronary in-stent restenosis identified using machine learning and bioinformatics

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 15, 2024

Percutaneous coronary intervention (PCI) combined with stent implantation is currently one of the most effective treatments for artery disease (CAD). However, in-stent restenosis (ISR) significantly compromises its long-term efficacy. Mitophagy plays a crucial role in vascular homeostasis, yet ISR remains unclear. This study aims to identify mitophagy-related biomarkers and explore their underlying molecular mechanisms. Through differential gene expression analysis between Control samples dataset, 169 differentially expressed genes (DEGs) were identified. Twenty-three (DEMRGs) identified by intersecting (MRGs) from GeneCards, functional enrichment indicated significant involvement biological processes. Using Weighted Gene Co-expression Network Analysis (WGCNA) three machine learning algorithms (Logistic-LASSO, RF, SVM-RFE), LRRK2, ANKRD13A as ISR. The nomogram based on these two also exhibited promising diagnostic performance Set Enrichment (GSEA) well immune infiltration analyses showed that closely associated inflammatory responses Furthermore, potential small molecule compounds therapeutic implications predicted using connectivity Map (cMAP) database. systematically investigated functions, providing new insights into early diagnosis precision treatment strategies

Язык: Английский

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Cardioprotective effect of Vitamin D on cardiac hypertrophy through improvement of mitophagy and apoptosis in an experimental rat model of levothyroxine -induced hyperthyroidism

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Сен. 9, 2024

Язык: Английский

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