Estimated Glucose Disposal Rate predicts the risk of incident Metabolic dysfunction-associated steatotic liver disease

Endocrine Practice, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Metabolic dysfunction-associated steatotic liver disease: A sexually dimorphic disease and breast and gynecological cancer

Metabolism, Год журнала: 2025, Номер unknown, С. 156190 - 156190

Опубликована: Март 1, 2025

Язык: Английский

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The Genetically Predicted Causal Associations Between Circulating 3-Hydroxybutyrate Levels and Malignant Neoplasms: A Pan-cancer Mendelian Randomization Study

Clinical Nutrition, Год журнала: 2024, Номер 43(11), С. 137 - 152

Опубликована: Окт. 1, 2024

Язык: Английский

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The burden of cancer in metabolic dysfunction-associated steatotic liver disease

Romanian Journal of Morphology and Embryology, Год журнала: 2025, Номер 65(4), С. 627 - 635

Опубликована: Фев. 13, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic worldwide and has become a major public health problem. MASLD frequently progresses to cirrhosis hepatocellular carcinoma, but recent studies also show frequent association with extrahepatic cancers. One of mechanisms involved in both locations insulin resistance hyperinsulinemia. The aim this narrative review was present main etiopathogenic cancer development patients MASLD.

Язык: Английский

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The Effect of Nonalcoholic Fatty Liver Disease on Extrahepatic Cancers: Evidence From Population‐Based Cohort and Mendelian Randomization

Health Science Reports, Год журнала: 2025, Номер 8(3)

Опубликована: Март 1, 2025

Nonalcoholic fatty liver disease (NAFLD) is an escalating global health concern with significant implications for cancers. A better understanding of the causal relationship between NAFLD and extrahepatic cancers might help in clinical management prevent its adverse outcomes. This study encompassed two complementary approaches. First, cross-sectional analysis was performed to examine association cancers, utilizing individual-level data from National Health Nutrition Examination Survey (2017-March 2020, 2021-2023 cycles). Logistic regression model utilized evaluate association. Subsequently, Mendelian randomization (MR) conducted explore Summary-level genetically predicted were derived large-scale genome-wide studies (GWAS), IEU Open GWAS project UK Biobank. The inverse variance weighting (IVW) method a random-effect as main analysis. total 10,010 participants included No observed after adjusting potential confounders, odd ratios (ORs) ranging 0.872 2.171. IVW MR showed genetic liability cALT imaging-and-biopsy confirmed not causally associated ORs 0.957 1.118 (all p > 0.050). Moreover, & bile duct cancer (OR = 1.001, 95% CI 1.000-1.001, 0.011; OR < 0.001), reinforcing well-documented link cancer. Our findings demonstrated that common Further research required validate these results mechanistic perspective.

Язык: Английский

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Relationship between anthropometric measures and the risk of incident Metabolic dysfunction-associated steatotic liver disease: a longitudinal study

BMC Gastroenterology, Год журнала: 2025, Номер 25(1)

Опубликована: Март 26, 2025

Waist circumference (WC) and body mass index (BMI) are considered useful for the diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to investigate association between roundness (BRI) a shape (ABSI) with incident MASLD, in comparison WC BMI. Retrospective cohort data from Japanese health check-up program were analyzed. Logistic regression model was used evaluate associations anthropometric measure quartiles receiver operating characteristic (ROC) analysis performed measures stratified by sex. A total 10,561 males 7,187 females included, whom 3,182 914 developed MASLD. Multivariate revealed that higher WC, BMI, BRI associated MASLD both sexes, whereas ABSI significantly only females. Among males, area under ROC curve (AUC) BMI than BRI, ABSI. Conversely, among females, AUC ABSI, it comparable or BRI. The optimal cut-off values predicting 0.77 23.9 kg/m2 0.86 22.2 82.0 cm 76.3 respectively. We demonstrated strongest compared other measures, particularly while also showing strong Additionally, specific criteria Asians improve needed.

Язык: Английский

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Interpretable Machine Learning reveals the Role of PANoptosis in the Diagnosis and Subtyping of NAFLD

Immunobiology, Год журнала: 2025, Номер 230(3), С. 152909 - 152909

Опубликована: Апрель 26, 2025

Язык: Английский

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Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

European Journal of Clinical Investigation, Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

Abstract Background Most forms of obesity are associated with chronic diseases that remain a global public health challenge. Aims Despite significant advancements in understanding its pathophysiology, effective management is hindered by the persistence knowledge gaps epidemiology, phenotypic heterogeneity and policy implementation. Materials Methods This consensus statement European Society for Clinical Investigation identifies eight critical areas requiring urgent attention. Key include insufficient long‐term data on trends, inadequacy body mass index (BMI) as sole diagnostic measure, recognition diversity obesity‐related cardiometabolic risks. Moreover, socio‐economic drivers transition across phenotypes poorly understood. Results The syndemic nature obesity, exacerbated globalization environmental changes, necessitates holistic approach integrating frameworks community‐level interventions. advocates leveraging emerging technologies, such artificial intelligence, to refine predictive models address variability. It underscores importance collaborative efforts among scientists, policymakers, stakeholders create tailored interventions enduring policies. Discussion highlights need harmonizing anthropometric biochemical markers, fostering inclusive narratives combating stigma obesity. By addressing these gaps, this initiative aims advance research, improve prevention strategies optimize care delivery people living Conclusion effort marks decisive step towards mitigating epidemic profound impact systems. Ultimately, should be considered being largely consequence model not compatible optimal human health.

Язык: Английский

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Omega-3 polyunsaturated fatty acids and Nonalcoholic fatty liver disease in adults: a meta-analysis of randomized controlled trials

Clinical Nutrition, Год журнала: 2025, Номер 50, С. 164 - 174

Опубликована: Май 20, 2025

Язык: Английский

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