Do Amyloid Cerebral Deposits Influence the Long-Term Poststroke Cognitive Outcome?: The IDEA3 Study DOI
Olivier Godefroy,

Niels Trinchard,

E. Marchal

и другие.

Stroke, Год журнала: 2024, Номер 56(1), С. 74 - 83

Опубликована: Дек. 9, 2024

BACKGROUND: Although the presence of amyloid deposits is associated with a more severe cognitive status in patients stroke at baseline, its influence on subsequent outcome has not been extensively assessed. The primary objective present study IDEA3 (Imagerie des dépôts amyloïdes cérébraux par florbetapir AV-45 et diagnostic déficits cognitifs démence post Accident Vasculaire Cérébral) cohort was to determine positron emission tomography (PET) 5-year outcome. METHODS: This longitudinal performed Amiens University Hospital (inclusions: October 2014 2019; last visits: 2018 February 2023) included 91 (ischemic stroke, 89%; hemorrhagic 11%) PET data baseline (positive, n=14). Patients underwent annually comprehensive clinical and assessments for 5 years after scan. incident dementia; secondary outcomes were impairment, total prevalence modified Rankin Scale score. RESULTS: A survival analysis (mean poststroke follow-up, 80.4±27 months) showed that incidence dementia higher PET-positive (odds ratio, 9.6 [95% CI, 2.5–36.9]; P =0.001), as impairment 10 1.9–52.3]; =0.003). Cox regression association between incidences ( =0.001) =0.007) still significant adjustment age, education, prestroke score type, status×stroke type interaction. Considering overall follow-up whole population (n=91 patients), positivity an elevated risk 6 1.76–20.5]; =0.002) 6.25 1.77–22]; =0.002). final did differ =0.3) according status. CONCLUSIONS: Our results demonstrate major impact deposition emphasized need etiologic workup impairment. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02813434.

Язык: Английский

Post-Stroke Outcome prediction based on lesion-derived features DOI Creative Commons

Maedeh Khalilian,

Olivier Godefroy,

Martine Roussel

и другие.

NeuroImage Clinical, Год журнала: 2025, Номер unknown, С. 103747 - 103747

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Analysis of clinical anatomical correlates of motor deficits in stroke by multivariate lesion inference based on game theory DOI Creative Commons
Monica N. Toba, Caroline Malherbe, Melissa Zavaglia

и другие.

Frontiers in Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Апрель 17, 2025

The exploration of causal functional inferences on the basis deficits observed after neurological impairments is often based separate study gray matter regions or white tracts. Here, we aimed at jointly analysing contributions and by using domain motor function approach iterative estimated Multi-perturbation Shapley Analysis (MSA), a multivariate game-theoretical lesion inference method. We analyzed scores assessed National Institute Health Stroke Scale (NIHSS) together with corresponding patterns 272 stroke patients finely parcellated map 150 tracts brain. MSA revealed small set essential to from internal capsule, cortico-spinal tract, cortico-ponto-cerebellum tract. These findings emphasize connectional anatomy and, methodological side, confirm that advanced method provides practical strategy for characterization brain functions resolved maps

Язык: Английский

Процитировано

0
Are we ready to cure post-stroke cognitive impairment? Many key prerequisites can be achieved quickly and easily DOI Creative Commons
Olivier Godefroy, Ardalan Aarabi, Yannick Béjot

и другие.

European Stroke Journal, Год журнала: 2024, Номер unknown

Опубликована: Авг. 11, 2024

Post-stroke (PS) cognitive impairment (CI) is frequent and its devastating functional vital consequences are well known. Despite recent guidelines, they still largely neglected. A large number of studies have re-examined the epidemiology, diagnosis, imaging determinants management PSCI. The aim this update to determine whether these new data answer questions that essential reducing PSCI, unmet needs, steps be taken.

Язык: Английский

Процитировано

1
Structural disconnections caused by white matter hyperintensities in post-stroke spatial neglect DOI Open Access
Lisa Röhrig, Hans‐Otto Karnath

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 31, 2024

Abstract White matter hyperintensities (WMH), a common feature of cerebral small vessel disease, affect wide range cognitive dysfunctions, including spatial neglect. The latter is disorder attention and exploration typically after right hemisphere brain damage. To explore the impact WMH on neglect-related structural disconnections, present study investigated indirectly quantified disconnectome induced by either stroke lesion alone, or their combination. Further, we compared different measures disconnections – voxel-wise, pairwise, tract-wise, parcel-wise to identify neural correlates predict acute neglect severity. We observed that WMH-derived alone were not associated behavior. However, when combined with derived from individual lesions, pre-stroke contributed post-stroke severity affecting frontal subcortical substrates, like middle gyrus, basal ganglia, thalamus, fronto-pontine tract. Predictive modeling demonstrated voxel-wise disconnection data outperformed other disconnection, explaining 42% total variance. Compared using anatomy, prediction performance can be improved estimating stroke-based delineating anatomy WMH. conclude alterations in white microstructure due contribute deficits attention, likely impairing integrity human networks.

Язык: Английский

Процитировано

0
Structural Disconnections Caused by White Matter Hyperintensities in Post‐Stroke Spatial Neglect DOI Creative Commons
Lisa Röhrig, Hans‐Otto Karnath

Human Brain Mapping, Год журнала: 2024, Номер 45(17)

Опубликована: Ноя. 25, 2024

ABSTRACT White matter hyperintensities (WMH), a common feature of cerebral small vessel disease, affect wide range cognitive dysfunctions, including spatial neglect. The latter is disorder attention and exploration typically after right hemisphere brain damage. To explore the impact WMH on neglect‐related structural disconnections, present study investigated indirectly quantified disconnectome induced by either stroke lesion alone, or their combination. Furthermore, we compared different measures disconnection—voxel‐wise, pairwise, tract‐wise, parcel‐wise—to identify neural correlates predict acute neglect severity. We observed that WMH‐derived disconnections alone were not associated with behavior. However, when combined derived from individual lesions, pre‐stroke contributed to post‐stroke severity affecting frontal subcortical substrates, like middle gyrus, basal ganglia, thalamus, fronto‐pontine tract. Predictive modeling demonstrated voxel‐wise disconnection data outperformed other disconnection, explaining 42% total variance; interestingly, best model used predictors stroke‐based only. conclude prestroke alterations in white microstructure due contribute poststroke deficits attention, likely impairing integrity human networks.

Язык: Английский

Процитировано

0
Do Amyloid Cerebral Deposits Influence the Long-Term Poststroke Cognitive Outcome?: The IDEA3 Study DOI
Olivier Godefroy,

Niels Trinchard,

E. Marchal

и другие.

Stroke, Год журнала: 2024, Номер 56(1), С. 74 - 83

Опубликована: Дек. 9, 2024

BACKGROUND: Although the presence of amyloid deposits is associated with a more severe cognitive status in patients stroke at baseline, its influence on subsequent outcome has not been extensively assessed. The primary objective present study IDEA3 (Imagerie des dépôts amyloïdes cérébraux par florbetapir AV-45 et diagnostic déficits cognitifs démence post Accident Vasculaire Cérébral) cohort was to determine positron emission tomography (PET) 5-year outcome. METHODS: This longitudinal performed Amiens University Hospital (inclusions: October 2014 2019; last visits: 2018 February 2023) included 91 (ischemic stroke, 89%; hemorrhagic 11%) PET data baseline (positive, n=14). Patients underwent annually comprehensive clinical and assessments for 5 years after scan. incident dementia; secondary outcomes were impairment, total prevalence modified Rankin Scale score. RESULTS: A survival analysis (mean poststroke follow-up, 80.4±27 months) showed that incidence dementia higher PET-positive (odds ratio, 9.6 [95% CI, 2.5–36.9]; P =0.001), as impairment 10 1.9–52.3]; =0.003). Cox regression association between incidences ( =0.001) =0.007) still significant adjustment age, education, prestroke score type, status×stroke type interaction. Considering overall follow-up whole population (n=91 patients), positivity an elevated risk 6 1.76–20.5]; =0.002) 6.25 1.77–22]; =0.002). final did differ =0.3) according status. CONCLUSIONS: Our results demonstrate major impact deposition emphasized need etiologic workup impairment. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02813434.

Язык: Английский

Процитировано

0