Nanoparticles Enhancing Efficacy in Drug Formulation and Drug Delivery

Sustainable development and biodiversity, Год журнала: 2025, Номер unknown, С. 227 - 261

Опубликована: Янв. 1, 2025

Язык: Английский

---

Nanocarrier-based targeted drug delivery for Alzheimer’s disease: addressing neuroinflammation and enhancing clinical translation

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Май 14, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, amyloid-beta (Aβ) aggregation, tau pathology, and chronic neuroinflammation. Among these, neuroinflammation plays crucial role in exacerbating progression, making it an attractive therapeutic target. However, the presence of blood-brain barrier (BBB) significantly limits effective delivery agents to brain, necessitating novel drug strategies. Nanocarrier-based systems have emerged as promising solution these challenges, offering targeted transport, enhanced BBB penetration, improved bioavailability while minimizing systemic toxicity. This review explores current advancements nanocarrier-mediated for AD, focusing on mechanisms neuroinflammation, nanocarriers overcoming BBB, their ability modulate inflammatory pathways. Furthermore, discusses preclinical validation strategies key including safety concerns, large-scale production limitations, regulatory hurdles that must be addressed enable clinical translation. Future perspectives emphasize integration nanotechnology with precision medicine, gene therapy, artificial intelligence optimize nanocarrier design individualized AD treatment. By obstacles, hold potential revolutionize approaches other diseases.

Язык: Английский

---

Nanotechnology used for siRNA delivery for the treatment of neurodegenerative diseases: Focusing on Alzheimer’s disease and Parkinson’s disease

International Journal of Pharmaceutics, Год журнала: 2024, Номер 666, С. 124786 - 124786

Опубликована: Окт. 6, 2024

Язык: Английский

---

On the Axonal Transport of Lipid Nanoparticles in Primary Hippocampal Neurons

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106282 - 106282

Опубликована: Окт. 1, 2024

Язык: Английский

---

DNA origami-based nano-vaccines for cancer immunotherapy

Nano Trends, Год журнала: 2024, Номер 8, С. 100060 - 100060

Опубликована: Ноя. 16, 2024

Язык: Английский

---