Maternal Immune Activation Disrupts Epigenomic and Functional Maturation of Cortical Excitatory Neurons DOI Creative Commons
Chi-Yu Lai,

Jessica Arzavala,

Adoni Duarte

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Summary Elevated levels of maternal pro-inflammatory cytokines during gestation can disrupt offspring neural development, increasing the risk neurodevelopmental disorders. We studied effects Poly(I:C)-induced immune activation (PIC-MIA) mid-gestation on developing cortical excitatory neurons’ DNA methylation and transcriptome. PIC-MIA disrupted developmental regulation synapse-related genes implicated in autism spectrum Genomic regions that gain or lose normal development were altered following PIC-MIA, including transcription factor binding sites. The transcriptional changes consistent with a delay neuron maturation. Whole-cell recordings showed preferentially physiological layer 5 neurons. Taken together, present results suggest alterations epigenome, through disruption circuit formation, may drive long-term consequences infection gestation.

Язык: Английский

Maternal Immune Activation Disrupts Epigenomic and Functional Maturation of Cortical Excitatory Neurons DOI Creative Commons
Chi-Yu Lai,

Jessica Arzavala,

Adoni Duarte

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Summary Elevated levels of maternal pro-inflammatory cytokines during gestation can disrupt offspring neural development, increasing the risk neurodevelopmental disorders. We studied effects Poly(I:C)-induced immune activation (PIC-MIA) mid-gestation on developing cortical excitatory neurons’ DNA methylation and transcriptome. PIC-MIA disrupted developmental regulation synapse-related genes implicated in autism spectrum Genomic regions that gain or lose normal development were altered following PIC-MIA, including transcription factor binding sites. The transcriptional changes consistent with a delay neuron maturation. Whole-cell recordings showed preferentially physiological layer 5 neurons. Taken together, present results suggest alterations epigenome, through disruption circuit formation, may drive long-term consequences infection gestation.

Язык: Английский

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