Frontiers in Aging Neuroscience,
Год журнала:
2019,
Номер
11
Опубликована: Ноя. 20, 2019
Neurons
are
highly
specialized
postmitotic
cells
that
inherently
dependent
on
mitochondria
owing
to
their
high
bioenergetic
demand.
Mitochondrial
dysfunction
is
therefore
associated
with
various
age-related
neurodegenerative
disorders
such
as
Alzheimer's
disease
(AD),
wherein
accumulation
of
damaged
and
dysfunctional
has
been
reported
early
symptoms
further
contributing
progression.
In
AD,
impairment
mitochondrial
function
causes
deficiency,
intracellular
calcium
imbalance
oxidative
stress
thereby
aggravating
the
effect
Aβ
tau
pathologies,
leading
synaptic
dysfunction,
cognitive
memory
loss.
Although
there
reports
suggesting
intricate
parallelism
between
AD
pathologies
A
aggregation
hyperphosphorylated
accumulation,
factors
drive
pathogenesis
either
unclear.
addition,
emerging
evidence
suggests
quality
control
(QC)
mechanisms
mitophagy
impaired
in
AD.
As
an
important
QC
mechanism,
plays
a
critical
role
maintaining
neuronal
health
function.
Studies
show
different
proteins
involved
mitophagy,
dynamics
biogenesis
affected
The
compromised
may
also
be
attributed
autophagosome-lysosome
fusion
defects
lysosomal
acidification.
Therapeutic
interventions
aiming
restore
functions
can
used
strategy
for
ameliorating
pathogenesis.
Recent
implicates
microglial
activation
via
induction
reducing
amyloid
plaque
load.
This
review
summarizes
current
developments
field
Molecular Neurodegeneration,
Год журнала:
2019,
Номер
14(1)
Опубликована: Авг. 2, 2019
Alzheimer's
disease
is
a
progressive
neurodegenerative
most
often
associated
with
memory
deficits
and
cognitive
decline,
although
less
common
clinical
presentations
are
increasingly
recognized.
The
cardinal
pathological
features
of
the
have
been
known
for
more
than
one
hundred
years,
today
presence
these
amyloid
plaques
neurofibrillary
tangles
still
required
diagnosis.
cause
dementia
globally.
There
remain
no
effective
treatment
options
great
majority
patients,
primary
causes
unknown
except
in
small
number
familial
cases
driven
by
genetic
mutations.
Confounding
efforts
to
develop
diagnostic
tools
disease-modifying
therapies
realization
that
mixed
proteinopathy
(amyloid
tau)
frequently
other
age-related
processes
such
as
cerebrovascular
Lewy
body
disease.
Defining
relationships
between
interdependence
various
co-pathologies
remains
an
active
area
investigation.
This
review
outlines
etiologically-linked
pathologic
disease,
well
those
inevitable
findings
uncertain
significance,
granulovacuolar
degeneration
Hirano
bodies.
Other
frequent,
but
not
inevitable,
also
discussed,
including
can
clinically
mimic
These
include
TDP-43
proteinopathies
argyrophilic
grain
purpose
this
provide
overview
pathology,
its
defining
substrates
related
pathologies
affect
diagnosis
treatment.
JMIR mhealth and uhealth,
Год журнала:
2020,
Номер
8(11), С. e18907 - e18907
Опубликована: Сен. 24, 2020
With
the
rise
of
mobile
medicine,
development
new
technologies
such
as
smart
sensing,
and
popularization
personalized
health
concepts,
field
wearable
devices
has
developed
rapidly
in
recent
years.
Among
them,
medical
have
become
one
most
promising
fields.
These
intelligent
not
only
assist
people
pursuing
a
healthier
lifestyle
but
also
provide
constant
stream
care
data
for
disease
diagnosis
treatment
by
actively
recording
physiological
parameters
tracking
metabolic
status.
Therefore,
potential
to
mainstay
future
market.Although
previous
reviews
discussed
consumer
trends
electronics
application
technology
recreational
sporting
activities,
on
broad
clinical
usefulness
are
lacking.
We
aimed
review
current
while
highlighting
shortcomings
further
research.
In
addition
daily
safety
monitoring,
focus
our
work
was
mainly
use
practice.We
conducted
narrative
settings
searching
papers
PubMed,
EMBASE,
Scopus,
Cochrane
Library
published
since
October
2015.
Potentially
relevant
were
then
compared
determine
their
relevance
reviewed
independently
inclusion.A
total
82
drawn
from
960
subject
qualitatively
analyzed,
information
synthesized.
Our
shows
that
so
far
been
designed
all
parts
human
body,
including
head,
limbs,
torso.
can
be
classified
into
4
areas:
(1)
(2)
chronic
management,
(3)
treatment,
(4)
rehabilitation.
However,
device
industry
currently
faces
several
important
limitations
prevent
practice,
difficulties
achieving
user-friendly
solutions,
security
privacy
concerns,
lack
standards,
various
technical
bottlenecks.We
predict
with
science
will
play
greater
role
better
integrated
people's
lives.
more
research
is
needed
explore
applications
field.
hope
this
useful
reference
devices.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(22), С. 8765 - 8765
Опубликована: Ноя. 20, 2020
Ferroptosis
is
a
type
of
cell
death
that
was
described
less
than
decade
ago.
It
caused
by
the
excess
free
intracellular
iron
leads
to
lipid
(hydro)
peroxidation.
Iron
essential
as
redox
metal
in
several
physiological
functions.
The
brain
one
organs
known
be
affected
homeostatic
balance
disruption.
Since
1960s,
increased
concentration
central
nervous
system
has
been
associated
with
oxidative
stress,
oxidation
proteins
and
lipids,
death.
Here,
we
review
main
mechanisms
involved
process
ferroptosis
such
peroxidation,
glutathione
peroxidase
4
enzyme
activity,
metabolism.
Moreover,
association
pathophysiology
some
neurodegenerative
diseases,
namely
Alzheimer’s,
Parkinson’s,
Huntington’s
also
addressed.
Journal of Cerebral Blood Flow & Metabolism,
Год журнала:
2020,
Номер
40(1_suppl), С. S6 - S24
Опубликована: Сен. 14, 2020
The
blood–brain
barrier
(BBB)
is
a
critical
regulator
of
CNS
homeostasis.
It
possesses
physical
and
biochemical
characteristics
(i.e.
tight
junction
protein
complexes,
transporters)
that
are
necessary
for
the
BBB
to
perform
this
physiological
role.
Microvascular
endothelial
cells
require
support
from
astrocytes,
pericytes,
microglia,
neurons,
constituents
extracellular
matrix.
This
intricate
relationship
implies
existence
neurovascular
unit
(NVU).
NVU
cellular
components
can
be
activated
in
disease
contribute
dynamic
remodeling
BBB.
especially
true
resident
immune
brain,
which
polarize
into
distinct
proinflammatory
(M1)
or
anti-inflammatory
(M2)
phenotypes.
Current
data
indicate
M1
pro-inflammatory
microglia
dysfunction
vascular
“leak”,
while
M2
play
protective
role
at
Understanding
biological
mechanisms
involved
activation
provides
unique
opportunity
develop
novel
treatment
approaches
neurological
diseases.
In
review,
we
highlight
describe
how
these
phenotypes
modulate
physiology.
Additionally,
outline
other
cell
types
regulating
microglial
targeted
with
focus
on
ischemic
stroke
Alzheimer’s
disease.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2019,
Номер
60(19), С. 3290 - 3303
Опубликована: Ноя. 4, 2019
Quercetin,
one
of
the
most
taken
flavonoid
with
diet,
belongs
to
family
flavonols
in
which
kaempferol
and
myricetin
are
also
found.
Quercetin
occurs
as
a
glycoside
(with
linked
sugars)
or
an
aglycone
(without
sugars).
Although
quercetin
has
many
different
forms
nature,
form
found
plants
is
quercetin-3-O-glucoside,
generally
functions
pigment
that
gives
color
multitude
fruits
vegetables.
The
recent
literature
been
reviewed
using
PubMed,
Science
Direct,
Embase
databases.
In
this
article,
we
respect
chemical
properties,
absorption
mechanism,
metabolism,
bioavailability,
food
sources,
bioactivities,
possible
health-promoting
mechanisms.
known
antioxidant,
anti-inflammatory,
cardioprotective,
anti-obesity
compound.
It
thought
be
beneficial
against
cardiovascular
diseases,
cancer,
diabetes,
neurological
obesity,
allergy
asthma,
atopic
diseases.
Further
clinical
studies
large
sample
sizes
needed
determine
appropriate
dose
for
preventing
