Human Studies of Transcranial Ultrasound neuromodulation: A systematic review of effectiveness and safety

Brain stimulation, Год журнала: 2022, Номер 15(3), С. 737 - 746

Опубликована: Май 1, 2022

BackgroundTranscranial ultrasound stimulation (TUS) is gaining traction as a safe and non-invasive technique in human studies. There has been rapid increase TUS studies recent years, with more than half of to date published after 2020. This growth the relevant body literature necessitates comprehensive reviews update clinicians researchers.ObjectiveThe aim this work review an emphasis on devices, sonication parameters, outcome measures, results, adverse effects, well highlight future directions investigation.MethodsA systematic was conducted by searching Web Science PubMed databases January 12, 2022. Human were included.ResultsA total 35 identified using focused/unfocused devices. A 677 subjects belonging diverse cohorts (i.e., healthy, chronic pain, dementia, epilepsy, traumatic brain injury, depression) enrolled. The effects vary parameter-dependant fashion. Clinical, neurophysiological, radiological histological measures assessed. No severe reported any surveyed. Mild symptoms observed 3.4% (14/425) subjects, including headache, mood deterioration, scalp heating, cognitive problems, neck muscle twitches, anxiety, sleepiness pruritis.ConclusionsAlthough increasingly being used, still its early phases. can change short-term excitability connectivity, induce long-term plasticity, modulate behavior. New techniques should be used further elucidate underlying mechanisms identify application novel populations.

Язык: Английский

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Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings

npj Parkinson s Disease, Год журнала: 2022, Номер 8(1)

Опубликована: Апрель 19, 2022

Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based neurostimulation, with the potential of clinical implementation sensing-enabled Percept neurostimulator. We aim to characterize chronic electrophysiological activity during and validate beta-band as biomarker bradykinesia. Subthalamic was recorded stepwise amplitude increase OFF medication in 10 Parkinson's patients rest finger tapping. Offline analysis wavelet-transformed assessment inter-variable relationships linear mixed effects models were implemented. There suppression low-beta increasing intensity (p = 0.002). Low-beta power negatively correlated movement speed predictive velocity improvements < 0.001), beta 0.001). Here, we modulation motor performance. Our investigations support use electrophysiology therapy optimization, providing evidence aDBS.

Язык: Английский

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Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches

Frontiers in Neurology, Год журнала: 2022, Номер 13

Опубликована: Март 9, 2022

Deep brain stimulation (DBS) has advanced treatment options for a variety of neurologic and neuropsychiatric conditions. As the technology DBS continues to progress, efficacy will continue improve disease indications expand. Hardware advances such as longer-lasting batteries reduce frequency battery replacement segmented leads facilitate improvements in effectiveness have potential minimize side effects. Targeting specialized imaging sequences “connectomics” improved accuracy lead positioning trajectory planning. Software closed-loop remote programming enable be more personalized accessible technology. The future promising holds further quality life. In this review we address past, present DBS.

Язык: Английский

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Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients

npj Parkinson s Disease, Год журнала: 2023, Номер 9(1)

Опубликована: Янв. 7, 2023

Pathologically increased beta power has been described as a biomarker for Parkinson's disease (PD) and related to prolonged bursts of subthalamic synchronization. Here, we investigate the association between dynamics motor impairment in cohort 106 patients ON- OFF-medication state, using two different methods burst determination. We report frequency-specific correlation low duration with OFF dopaminergic medication. Furthermore, reduction correlated significantly symptom alleviation through Importantly, qualitatively similar results were yielded definition. Our findings validate robustness previous on pathological changes subcortical oscillations both frequency- well time-domain largest PD date important implications next-generation adaptive deep brain stimulation control algorithms.

Язык: Английский

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Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions

Brain, Год журнала: 2023, Номер 146(11), С. 4456 - 4468

Опубликована: Июль 13, 2023

Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of Parkinson's disease and other neurological psychiatric disorders. Electrodes are chronically implanted in disease-relevant regions pulsatile electrical delivery intended to restore neurocircuit function. However, widespread interest application expansion this clinical therapy has preceded an overarching understanding alterations invoked by deep stimulation. Over years, various forms neurophysiological evidence have emerged which demonstrate changes activity across spatiotemporal resolutions; from single neuron, local field potential, brain-wide cortical network effects. Though fruitful, such studies often led debate about singular putative mechanism. In Update we aim produce integrative account complementary instead mutually exclusive effects derive generalizable concept mechanisms particular, offer critical review most common historical competing theories, updated discussion on recent literature animal human studies, synthesis synaptic scales observation, including micro-, meso- macroscale circuit alterations.

Язык: Английский

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Insights and opportunities for deep brain stimulation as a brain circuit intervention

Trends in Neurosciences, Год журнала: 2023, Номер 46(6), С. 472 - 487

Опубликована: Апрель 25, 2023

Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into the dynamic circuit architecture of disorders. This Review illustrates our current understanding pathophysiology movement disorders their underlying circuits that are modulated with DBS. It proposes principles pathological network synchronization patterns like beta activity (13–35 Hz) in Parkinson's disease. We describe alterations from microscale including local synaptic via modulation mesoscale hypersynchronization to changes whole-brain macroscale connectivity. Finally, outlook on advances for clinical innovations next-generation neurotechnology provided: preoperative connectomic targeting feedback controlled closed-loop adaptive DBS as individualized network-specific interventions.

Язык: Английский

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Local field potentials in Parkinson's disease: A frequency-based review

Neurobiology of Disease, Год журнала: 2021, Номер 155, С. 105372 - 105372

Опубликована: Апрель 29, 2021

Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field potentials (LFPs), the electrophysiological population activity of neurons surrounding depth electrode in target area. With direct access subcortical activity, LFP research has provided valuable insight into disease mechanisms and cognitive processes inspired advent adaptive DBS for Parkinson's (PD). A frequency-based framework is usually employed interpret implications signatures studies on PD. This approach standardizes methodology, simplifies interpretation patterns, makes results comparable across studies. Importantly, previous works have found that patterns do not represent disease-specific but rather symptom-specific or task-specific neuronal relate current motor, emotional state patient underlying disease. In present review, we aim highlight distinguishing features frequency-specific activities, mainly within motor domain, recorded from electrodes patients with Associations commonly reported frequency bands (delta, theta, alpha, beta, gamma, high-frequency oscillations) signs are discussed respect band-related phenomena such as individual tremor high/low beta well dynamic transients bursts. We provide an overview how electrophysiology revealed will continuously reveal new information about pathophysiology, symptoms, behavior, e.g., when combining deep surface electrocorticography recordings.

Язык: Английский

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Clinical neurophysiology of Parkinson’s disease and parkinsonism

Clinical Neurophysiology Practice, Год журнала: 2022, Номер 7, С. 201 - 227

Опубликована: Янв. 1, 2022

This review is part of the series on clinical neurophysiology movement disorders. It focuses Parkinson’s disease and parkinsonism. The topics covered include pathophysiology tremor, rigidity bradykinesia, balance gait disturbance myoclonus in disease. use electroencephalography, electromyography, long latency reflexes, cutaneous silent period, studies cortical excitability with single paired transcranial magnetic stimulation, plasticity, intraoperative microelectrode recordings recording local field potentials from deep brain electrocorticography are also reviewed. In addition to advancing knowledge pathophysiology, neurophysiological can be useful refining diagnosis, localization surgical targets, help develop novel therapies for

Язык: Английский

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Diurnal modulation of subthalamic beta oscillatory power in Parkinson’s disease patients during deep brain stimulation

npj Parkinson s Disease, Год журнала: 2022, Номер 8(1)

Опубликована: Июль 8, 2022

Beta-band activity in the subthalamic local field potential (LFP) is correlated with Parkinson's disease (PD) symptom severity and therapeutic target of deep brain stimulation (DBS). While beta fluctuations PD patients are well characterized on shorter timescales, it not known how evolves around diurnal cycle, outside a clinical setting. Here, we obtained chronic recordings (34 ± 13 days) power implanted Percept DBS device during high-frequency analysed their properties as sensitivity to artifacts. Time day explained 41 9% variance (p < 0.001 all patients), increased reduced at night. Certain movements affected LFP quality, which may have contributed patterns some patients. Future algorithms benefit from taking such artifactual into account.

Язык: Английский

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Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease

eLife, Год журнала: 2022, Номер 11

Опубликована: Май 27, 2022

Brain signal decoding promises significant advances in the development of clinical brain computer interfaces (BCI). In Parkinson’s disease (PD), first bidirectional BCI implants for adaptive deep stimulation (DBS) are now available. can extend utility DBS but impact neural source, computational methods and PD pathophysiology on performance unknown. This represents an unmet need future neurotechnology. To address this, we developed invasive brain-signal approach based intraoperative sensorimotor electrocorticography (ECoG) subthalamic LFP to predict grip-force, a representative movement application, 11 patients undergoing DBS. We demonstrate that ECoG is superior accurate grip-force decoding. Gradient boosted decision trees (XGBOOST) outperformed other model architectures. negatively correlated with motor impairment, which could be attributed beta bursts preparation period. highlights capacity encode vigor. Finally, connectomic analysis individual channels across by using their fingerprints. Our study provides neurophysiological framework aid individualized precision-medicine intelligent

Язык: Английский

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