International Journal of Neuroscience, Год журнала: 2024, Номер unknown, С. 1 - 11
Опубликована: Авг. 29, 2024
Post coronavirus disease 2019 (COVID-19) pandemic, the widespread emergence and persistence of brain fog has led to a decline in people's productivity quality life. However, clinical characteristics COVID-19-associated are unclear, standardized assessments lacking. This study aims develop scale for assessment support practice research.
Язык: Английский
EClinicalMedicine, Год журнала: 2024, Номер 74, С. 102756 - 102756
Опубликована: Июль 27, 2024
Язык: Английский
Процитировано
9
Biomarkers in Neuropsychiatry, Год журнала: 2025, Номер 12, С. 100121 - 100121
Опубликована: Фев. 6, 2025
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Апрель 29, 2024
Abstract Post-COVID condition (PCC) and multiple sclerosis (MS) share some clinical demographic features, including cognitive symptoms fatigue. Some pathophysiological mechanisms well-known in MS, such as autoimmunity, neuroinflammation myelin damage, have also been implicated PCC. In this study, we aimed to compare the phenotypes of two large cohorts patients with PCC evaluate relationship between fatigue performance. Cross-sectional study 218 MS matched by age, sex, years education. Patients were evaluated a comprehensive neuropsychological protocol categorized according International Classification Cognitive Disorders system. Fatigue depression assessed. profiles largely overlapped, greater impairment episodic memory but small effect sizes. The most salient deficits both disorders attention processing speed. severity was Still, correlations tests more prominent case MS. There no differences among groups. Our found similar severe PCC, associated performance Further comparative studies addressing related dysfunction may be interest advance knowledge these develop new therapies.
Язык: Английский
Процитировано
4
European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2024, Номер unknown
Опубликована: Май 13, 2024
Abstract Cognitive symptoms (CS) belong to the most common manifestations of Post COVID-19 (PC) condition. We sought objectify CS in PC patients using routine diagnostic assessments: neurocognitive testing (NCT) and brain imaging (BI). Further, we investigated possible associations with patient reported outcomes (PROs), risk factors for developing CS. Clinical data PROs 315 were assessed at a mean 6 months after SARS-CoV-2 infection. 231 (73.3%) any sort Among them, 78 underwent NCT 55 received BI. In NCT, cognitive domains affected working memory, attention, concentration. Nonetheless, pathological thresholds exceeded only few cases. Neurocognitive performance did not differ significantly between complaining severe (n = 26) versus non-severe 52) BI findings abnormal 8 (14.5%) cases but likely related PC. Patients reporting high severity scored worse PHQ-9, FSS, WHOQOL-BREF, more report impaired sleep, had higher prevalence psychiatric diagnoses. Overall, could confirm mild impairment some all CS, while studies affect results, associated depression (PHQ-9), fatigue (FSS), reduced quality life (WHOQOL-BREF) illnesses. These support importance BI, neuro-psychological assessment work-up Trial registration number date registration: DRKS00030974, 22 Dec 2022, retrospectively registered.
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Июнь 5, 2024
Abstract We aimed to characterize the cognitive profile of post-acute COVID-19 syndrome (PACS) patients with complaints, exploring influence biological and psychological factors. Participants confirmed SARS-CoV-2 infection complaints ≥ 8 weeks phase were included. A comprehensive neuropsychological battery (NPS) health questionnaires administered at inclusion 1, 3 6 months. Blood samples collected each visit, MRI scan baseline months, and, optionally, cerebrospinal fluid. Cognitive features analyzed in relation clinical, neuroimaging, biochemical markers follow-up. Forty-nine participants, a mean time from symptom onset 10.4 showed attention-executive function (69%) verbal memory (39%) impairment. Apathy (64%), moderate-severe anxiety (57%), severe fatigue (35%) prevalent. Visual (8%) correlated total gray matter (GM) subcortical GM volume. Neuronal damage inflammation within normal limits. Over time, test scores, depression, apathy, indexes, fluid biomarkers remained stable, although fewer participants (50% vs. 75.5%; p = 0.012) exhibited abnormal evaluations Altered attention/executive memory, common PACS, persisted most subjects without association structural abnormalities, elevated cytokines, or neuronal markers.
Язык: Английский
Процитировано
4
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Annals of Clinical and Translational Neurology, Год журнала: 2023, Номер 11(2), С. 302 - 320
Опубликована: Дек. 21, 2023
Abstract Objective A long‐term decline in health‐related quality of life (HRQoL) has been reported after coronavirus disease 2019 (COVID‐19). Studies with people persistent symptoms showed inconsistent outcomes. Cognition and emotion are important determinants HRQoL, but few studies have examined their prognostic significance for HRQoL functionality post‐COVID patients persisting symptoms. We aimed to describe QoL, functioning individuals varying COVID‐19 severities investigate the predictive value cognitive emotional variables functioning. Methods In total, 492 participants (398 124 healthy controls) underwent a neurobehavioral examination that included assessments cognition, mood, QoL/HRQoL (WHOQOL‐BREF, EQ‐5D), (WHODAS‐II). Analysis covariance linear regression models were used study intergroup differences relationship between QoL Results The Physical Psychological dimensions WHOQoL, EQ‐5D, WHODAS Cognition, Mobility, Life Activities, Participation significantly lower groups compared control group. Regression explaining 23.9%–53.9% variance obtained WHOQoL‐BREF depressive symptoms, employment status, income, mental speed processing as main predictors. For WHODAS, 17%–60.2% obtained. Fatigue, processing, Interpretation than non‐affected persons. Depressive fatigue, slower predictors
Язык: Английский
Процитировано
9
Frontiers in Human Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Июнь 6, 2024
Importance Brain fog is associated with significant morbidity and reduced productivity gained increasing attention after COVID-19. However, this subjective state has not been systematically characterised. Objective To characterise self-reported brain fog. Design We studied the cross-sectional associations between 29 a priori variables presence of “brain fog.” The were grouped into four categories: demographics, symptoms functional impairments, comorbidities potential risk factors (including lifestyle factors), cognitive score. Univariate methods determined correlates fog, long-COVID non-long-COVID subgroups. XGBoost machine learning model retrospectively characterised Bonferroni-corrected statistical significance was set at 5%. Setting Digital application for remote data collection. Participants 25,796 individuals over age 18 who downloaded completed application. Results 7,280 (28.2%) reported experiencing generally older (mean 35.7 ± 11.9 years vs. 32.8 11.6 years, p < 0.0001) more likely to be female (OR = 1.2, 0.001). Associated impairments included d ifficulty focusing or concentrating 3.3), feeling irritable 1.6), difficulty relaxing all 0.0001), following conversations 2.2), remembering appointments 1.9), completing paperwork performing mental arithmetic (ORs 1.8, 0.0001). Comorbidities long-COVID-19 3.8, concussions 2.4, higher migraine disability assessment scores (MIDAS) (+34.1%, Cognitive marginally lower (−0.1 std., achieved training accuracy 85% cross-validated 74%, features most predictive in conversations, long-COVID, severity migraines. Conclusions relevance This largest study characterising as an impairment concentration activities daily living. particularly history long-COVID-19, migraines, concussion, 0.1 standard deviations scores, especially on modified Stroop testing, suggesting ability inhibit interference. Further prospective studies unselected sufferers should explore full spectrum differentiate it from its conditions.
Язык: Английский
Процитировано
3
Psychiatry Research, Год журнала: 2024, Номер 340, С. 116113 - 116113
Опубликована: Авг. 3, 2024
Язык: Английский
Процитировано
2
Frontiers in Human Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Авг. 13, 2024
Objective To analyze patient-reported outcomes, cognitive function, and persistent symptoms in patients with neurologic post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC) Colombia. Methods We recruited laboratory-confirmed COVID-19 PASC lasting more than 6 weeks at the CES University Clinic (Medellín, Colombia). included 50 post-hospitalization Neuro-PASC (PNP) non-hospitalized (NNP) patients. Long-COVID symptoms, (NIH Toolbox v2.1-Spanish for 18+), (PROMIS) relevant medical history were evaluated. Statistical analyses performed via generalized linear models. Results Overall, brain fog (60%), myalgia (42%), numbness or tingling (41%) most common neurological while fatigue (74%), sleep problems (46%), anxiety (44%) non-neurological symptoms. Compared to NNP, PNP showed a higher frequency abnormal exam findings (64% vs. 42%, p = 0.028). Both groups had impaired quality life (QoL) domains cognition, fatigue, depression disturbance, worse on processing speed attention normative population. In addition, NNP executive function (T-score 42.6 48.5, 0.012). associated QoL outcomes. Brain remained across all durations Long COVID. Conclusion Our highlight high incidence heterogeneity impacts COVID even 2 years from disease onset. Early detection, emotional support targeted management are warranted.
Язык: Английский
Процитировано
2