Putaminal-cortical circuits predict response of bilateral deep brain stimulation of the subthalamic nucleus in the primary Meige syndrome after 5 years DOI Creative Commons
Ning Wang, Yifeng Wu, Yao Chen

и другие.

Brain Communications, Год журнала: 2024, Номер 7(1)

Опубликована: Дек. 24, 2024

Abstract The deep brain stimulation (DBS) in the subthalamic nucleus (STN) has attracted more attention for primary Meige syndrome due to easier target location and lower power consumption. However, potential reliable preoperative predictors of longitudinal outcomes STN-DBS guide therapeutic decisions remain largely unexplored. Herein, we used structural MRI Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS) from 55 patients with who finished after 5 years. They were further classified into response (n = 23) super-response 32) based on improvement rates BFMDRS. Voxel-based morphology, partial correlation analyses, receiver operating characteristic (ROC) analyses support vector machine performed. We identified that improved BFMDRS 63, 71.97, 76.64, 79.51, 81.02, 81.36, 81.16, 80.80 80.93% at 1, 3, 6, 12, 18, 24, 36, 48 60 months STN-DBS, respectively, remained steady across 1–5 Further voxel-based morphology revealed significantly grey-matter volume right hippocampus, left putamen, supramarginal gyrus superior frontal when compared super-response. volumes not only positively correlated years syndrome, but also presented a classification ability distinguishing (area under curve 0.855). These results suggested is an effective treatment putaminal-cortical circuits could be as biomarkers predict outcomes.

Язык: Английский

Sustained quality-of-life improvements over 10 years after subthalamic nucleus deep brain stimulation for isolated dystonia DOI
Shaoyi Zhang, Yanjing Li, Dian Chen

и другие.

Journal of Neurology, Год журнала: 2025, Номер 272(1)

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Subthalamic nucleus deep brain stimulation in primary Meige syndrome: motor and non‐motor outcomes DOI Creative Commons
Qingpei Hao, Wentao Zheng,

Zi‐Hao Zhang

и другие.

European Journal of Neurology, Год журнала: 2023, Номер 31(2)

Опубликована: Ноя. 7, 2023

Abstract Background and purpose Deep brain stimulation (DBS) has emerged as a promising treatment for movement disorders. This prospective study aims to evaluate the effects of bilateral subthalamic nucleus DBS (STN‐DBS) on motor non‐motor symptoms in patients with primary Meige syndrome. Methods Thirty who underwent STN‐DBS between April 2017 June 2020 were included. Standardized validated scales utilized assess severity dystonia, health‐related quality life, sleep, cognitive function mental status at baseline 1 year 3 years after neurostimulation. Results The Burke−Fahn−Marsden Dystonia Rating Scale scores showed mean improvement 63.0% 66.8% years, respectively, Similarly, disability improved by 60.8% 63.3% same time points. Postoperative life demonstrated significant sustained throughout follow‐up period. However, function, status, sleep other neuropsychological functions did not change Eight adverse events occurred six patients, but no deaths or permanent sequelae reported. Conclusions Bilateral is safe effective alternative syndrome, leading improvements life. Nevertheless, it yield amelioration cognitive, mental,

Язык: Английский

Процитировано

5

Development and Validation of a Nomogram Based on Inflammatory Markers for Risk Prediction in Meige Syndrome Patients DOI Creative Commons

Runing Fu,

Wenping Lian, Bohao Zhang

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 7721 - 7731

Опубликована: Окт. 1, 2024

Inflammatory markers are known to be associated with many diseases, but their role in Meige syndrome (MS) remains unclear. This study aimed develop and validate a nomogram for the risk prediction of MS based on inflammatory markers.

Язык: Английский

Процитировано

1

Surface-Based Morphometry Findings Reveal Structural Alterations of the Brain in Meige Syndrome DOI Open Access
Yan Tang, Ruen Liu

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Год журнала: 2024, Номер unknown, С. 1 - 9

Опубликована: Дек. 12, 2024

ABSTRACT Objective: To compare structural alterations in the brains of Meige syndrome (MS) patients with those healthy controls (HCs) by using surface-based morphometry (SBM) and differences between MS sleep disorders without disorders. Methods: We investigated cortical surface parameters 42 30 HCs. T1-weighted images were acquired processed CAT12 to perform vertexwise between-group comparisons thickness, gyrification, complexity sulcus depth validated quality control protocols. also performed SBM analyze data from 19 23 Results: Compared HCs, had large clusters regions, especially postcentral, precentral, superior frontal paracentral thickness. Differences observed parietal occipital areas. Among disorders, altered sulcal observed. Conclusions: This study strongly suggested that have abnormalities compared thus elucidating underlying pathophysiology motor nonmotor symptoms patients.

Язык: Английский

Процитировано

0

Putaminal-cortical circuits predict response of bilateral deep brain stimulation of the subthalamic nucleus in the primary Meige syndrome after 5 years DOI Creative Commons
Ning Wang, Yifeng Wu, Yao Chen

и другие.

Brain Communications, Год журнала: 2024, Номер 7(1)

Опубликована: Дек. 24, 2024

Abstract The deep brain stimulation (DBS) in the subthalamic nucleus (STN) has attracted more attention for primary Meige syndrome due to easier target location and lower power consumption. However, potential reliable preoperative predictors of longitudinal outcomes STN-DBS guide therapeutic decisions remain largely unexplored. Herein, we used structural MRI Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS) from 55 patients with who finished after 5 years. They were further classified into response (n = 23) super-response 32) based on improvement rates BFMDRS. Voxel-based morphology, partial correlation analyses, receiver operating characteristic (ROC) analyses support vector machine performed. We identified that improved BFMDRS 63, 71.97, 76.64, 79.51, 81.02, 81.36, 81.16, 80.80 80.93% at 1, 3, 6, 12, 18, 24, 36, 48 60 months STN-DBS, respectively, remained steady across 1–5 Further voxel-based morphology revealed significantly grey-matter volume right hippocampus, left putamen, supramarginal gyrus superior frontal when compared super-response. volumes not only positively correlated years syndrome, but also presented a classification ability distinguishing (area under curve 0.855). These results suggested is an effective treatment putaminal-cortical circuits could be as biomarkers predict outcomes.

Язык: Английский

Процитировано

0