Sustained quality-of-life improvements over 10 years after subthalamic nucleus deep brain stimulation for isolated dystonia
Journal of Neurology,
Год журнала:
2025,
Номер
272(1)
Опубликована: Янв. 1, 2025
Язык: Английский
Subthalamic nucleus deep brain stimulation in primary Meige syndrome: motor and non‐motor outcomes
European Journal of Neurology,
Год журнала:
2023,
Номер
31(2)
Опубликована: Ноя. 7, 2023
Abstract
Background
and
purpose
Deep
brain
stimulation
(DBS)
has
emerged
as
a
promising
treatment
for
movement
disorders.
This
prospective
study
aims
to
evaluate
the
effects
of
bilateral
subthalamic
nucleus
DBS
(STN‐DBS)
on
motor
non‐motor
symptoms
in
patients
with
primary
Meige
syndrome.
Methods
Thirty
who
underwent
STN‐DBS
between
April
2017
June
2020
were
included.
Standardized
validated
scales
utilized
assess
severity
dystonia,
health‐related
quality
life,
sleep,
cognitive
function
mental
status
at
baseline
1
year
3
years
after
neurostimulation.
Results
The
Burke−Fahn−Marsden
Dystonia
Rating
Scale
scores
showed
mean
improvement
63.0%
66.8%
years,
respectively,
Similarly,
disability
improved
by
60.8%
63.3%
same
time
points.
Postoperative
life
demonstrated
significant
sustained
throughout
follow‐up
period.
However,
function,
status,
sleep
other
neuropsychological
functions
did
not
change
Eight
adverse
events
occurred
six
patients,
but
no
deaths
or
permanent
sequelae
reported.
Conclusions
Bilateral
is
safe
effective
alternative
syndrome,
leading
improvements
life.
Nevertheless,
it
yield
amelioration
cognitive,
mental,
Язык: Английский
Development and Validation of a Nomogram Based on Inflammatory Markers for Risk Prediction in Meige Syndrome Patients
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 7721 - 7731
Опубликована: Окт. 1, 2024
Inflammatory
markers
are
known
to
be
associated
with
many
diseases,
but
their
role
in
Meige
syndrome
(MS)
remains
unclear.
This
study
aimed
develop
and
validate
a
nomogram
for
the
risk
prediction
of
MS
based
on
inflammatory
markers.
Язык: Английский
Surface-Based Morphometry Findings Reveal Structural Alterations of the Brain in Meige Syndrome
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques,
Год журнала:
2024,
Номер
unknown, С. 1 - 9
Опубликована: Дек. 12, 2024
ABSTRACT
Objective:
To
compare
structural
alterations
in
the
brains
of
Meige
syndrome
(MS)
patients
with
those
healthy
controls
(HCs)
by
using
surface-based
morphometry
(SBM)
and
differences
between
MS
sleep
disorders
without
disorders.
Methods:
We
investigated
cortical
surface
parameters
42
30
HCs.
T1-weighted
images
were
acquired
processed
CAT12
to
perform
vertexwise
between-group
comparisons
thickness,
gyrification,
complexity
sulcus
depth
validated
quality
control
protocols.
also
performed
SBM
analyze
data
from
19
23
Results:
Compared
HCs,
had
large
clusters
regions,
especially
postcentral,
precentral,
superior
frontal
paracentral
thickness.
Differences
observed
parietal
occipital
areas.
Among
disorders,
altered
sulcal
observed.
Conclusions:
This
study
strongly
suggested
that
have
abnormalities
compared
thus
elucidating
underlying
pathophysiology
motor
nonmotor
symptoms
patients.
Язык: Английский
Putaminal-cortical circuits predict response of bilateral deep brain stimulation of the subthalamic nucleus in the primary Meige syndrome after 5 years
Brain Communications,
Год журнала:
2024,
Номер
7(1)
Опубликована: Дек. 24, 2024
Abstract
The
deep
brain
stimulation
(DBS)
in
the
subthalamic
nucleus
(STN)
has
attracted
more
attention
for
primary
Meige
syndrome
due
to
easier
target
location
and
lower
power
consumption.
However,
potential
reliable
preoperative
predictors
of
longitudinal
outcomes
STN-DBS
guide
therapeutic
decisions
remain
largely
unexplored.
Herein,
we
used
structural
MRI
Burke–Fahn–Marsden
Dystonia
Rating
Scale
(BFMDRS)
from
55
patients
with
who
finished
after
5
years.
They
were
further
classified
into
response
(n
=
23)
super-response
32)
based
on
improvement
rates
BFMDRS.
Voxel-based
morphology,
partial
correlation
analyses,
receiver
operating
characteristic
(ROC)
analyses
support
vector
machine
performed.
We
identified
that
improved
BFMDRS
63,
71.97,
76.64,
79.51,
81.02,
81.36,
81.16,
80.80
80.93%
at
1,
3,
6,
12,
18,
24,
36,
48
60
months
STN-DBS,
respectively,
remained
steady
across
1–5
Further
voxel-based
morphology
revealed
significantly
grey-matter
volume
right
hippocampus,
left
putamen,
supramarginal
gyrus
superior
frontal
when
compared
super-response.
volumes
not
only
positively
correlated
years
syndrome,
but
also
presented
a
classification
ability
distinguishing
(area
under
curve
0.855).
These
results
suggested
is
an
effective
treatment
putaminal-cortical
circuits
could
be
as
biomarkers
predict
outcomes.
Язык: Английский