Baseline engagement with healthy lifestyles and their associations with health outcomes in people with multiple sclerosis enrolled in an online multimodal lifestyle course
European Journal of Neurology,
Год журнала:
2024,
Номер
31(10)
Опубликована: Авг. 7, 2024
Healthy
lifestyle
behaviour
modification
may
improve
health
outcomes
in
people
with
multiple
sclerosis
(pwMS),
but
empirical
evidence
is
needed
to
confirm
prior
study
findings.
We
developed
an
online
multimodal
intervention
(Multiple
Sclerosis
Online
Course)
examine
the
impact
of
on
pwMS
via
a
randomized
control
trial
(RCT).
However,
present
specifically
analyses
baseline
data
assess
engagement
healthy
lifestyles
by
RCT
participants
and
cross-sectional
associations
outcomes.
Язык: Английский
From prevention to management: Exploring the impact of diet on multiple sclerosis
Translational Neuroscience,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 1, 2025
Multiple
sclerosis
(MS)
is
a
chronic
immune-mediated
disease
of
the
central
nervous
system
characterized
by
neuroinflammation
and
progressive
neurodegeneration.
Growing
evidence
suggests
that
dietary
interventions
may
influence
MS
progression
symptom
management
modulating
inflammation,
oxidative
stress,
gut
microbiota
composition.
This
narrative
review
examines
effects
Mediterranean,
plant-based,
ketogenic,
Wahls,
Swank,
intermittent
fasting,
gluten-free
diets,
alongside
key
nutrients
such
as
omega-3
fatty
acids,
vitamin
D,
polyphenols,
antioxidants.
Among
these,
Mediterranean
plant-based
diets
have
shown
most
consistent
benefits,
including
reductions
in
fatigue,
improved
quality
life,
modulation
inflammatory
markers.
The
Wahls
Swank
show
promise
but
are
primarily
supported
studies
from
their
respective
research
groups,
raising
concerns
about
long-term
adherence
nutritional
adequacy.
ketogenic
diet
fasting
yielded
mixed
findings,
with
some
suggesting
benefits
for
fatigue
neuroprotection,
while
others
highlight
potential
metabolic
risks.
supplementation
lack
robust
evidence,
inconsistent
findings
across
studies.
Additionally,
ultra-processed
foods
high
saturated
fats
been
associated
increased
inflammation
greater
severity.
Despite
promising
limitations
small
sample
sizes,
short
follow-up
durations,
study
design
inconsistencies
prevent
definitive
conclusions.
Future
should
prioritize
large-scale,
randomized
controlled
trials
to
establish
efficacy,
safety,
sustainability
management.
Mechanistic
standardized
protocols
also
needed
better
understand
role
control.
Язык: Английский
Lifestyle, Cognition, and Disability Outcomes in Multiple Sclerosis: A Comprehensive Cohort Study
Sclerosis,
Год журнала:
2024,
Номер
2(4), С. 394 - 404
Опубликована: Дек. 18, 2024
Background/Objectives:
People
with
multiple
sclerosis
(MS)
often
experience
sensory,
psychomotor,
and
cognitive
impairment,
sphincter
disturbances,
fatigue,
which
can
affect
their
ability
to
perform
work-related
tasks,
self-care,
daily
activities.
This
study
aimed
analyze
the
lifestyle
changes,
function,
disability
outcomes
over
a
seven-year
follow-up
period,
exploring
potential
associations
predictive
markers.
Methods:
At
end
of
32
participants
returned
for
clinical
reassessment
Twenty-Five-Foot
Walk
Test,
Nine-Hole
Peg
Brief
Repeatable
Neuropsychological
Battery.
Lifestyle
data
were
acquired
via
interviews
regarding
sleep
quality,
reading
habits,
technology
use,
physical
activity
levels,
household
responsibilities,
participation
in
leisure
cultural
Results:
The
occupational
profile
did
not
demonstrate
significant
but
11
(34%)
showed
accumulation,
number
relapses
increased
(p
=
0.001).
Over
time,
improvement
was
observed
verbal
episodic
memory
worsening
psychomotor
speed.
Better
performance
mental
agility
associated
higher
levels
0.021)
use
0.039).
In
addition,
better
cognition
(verbal
p
0.038
processing
speed
0.015)
(upper
limbs
0.017
lower
0.003)
functional
0.022)
maintenance
Conclusions:
changes
more
prominent
memory,
speed,
good
mainly
treatment
strategies
should
include
pharmacological
interventions.
Язык: Английский