Possible Significance of Neutrophil–Hemoglobin Ratio in Differentiating Progressive Supranuclear Palsy from Depression: A Pilot Study

Diseases, Год журнала: 2025, Номер 13(4), С. 119 - 119

Опубликована: Апрель 18, 2025

Background: Research has associated chronic inflammation with the evolution of neurological and psychiatric disorders. Neurodegenerative diseases, including Parkinson’s Disease (PD), Alzheimer’s (AD), less common ones such as Progressive Supranuclear Palsy (PSP), are commonly linked to depression. However, pathomechanisms role neuroinflammation in these disorders remain unclear; therefore, interest is increasing easily accessible inflammatory morphological assessments blood samples, neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte (NMR), neutrophil-to-hemoglobin (N/HGBR). Methods: The authors analyzed 15 age-matched controls 21 patients PSP; PSP group was additionally divided into 11 without depression (PSP) 10 (Beck Depression Inventory [BDI] ≥ 14) (PSP-D). Results: In PSP-D group, level N/HGBR significantly lower than (p = 0.01), but there were no significant differences any other neutrophil-derived parameters or comparisons assessment. Patients exhibited a marginally decrease neutrophil levels compared controls. Conclusions: This first study highlighting possible significance peripheral factors affected by It highlights tendencies area non-specific markers suggests their relation affective PSP.

Язык: Английский

Peripheral immune profile and neutrophil‐to‐lymphocyte ratio in progressive supranuclear palsy: Case–control study and meta‐analysis

European Journal of Neurology, Год журнала: 2024, Номер 31(12)

Опубликована: Авг. 20, 2024

Abstract Background and purpose Peripheral inflammation is probably involved in the pathogenesis of progressive supranuclear palsy (PSP) it may be a common feature with Parkinson's disease (PD). The peripheral immune profile PSP remains unclear, as well whether inflammatory pathways differ from those PD. neutrophil‐to‐lymphocyte ratio (NLR) has been proven to well‐established biomarker systemic inflammation. This study aimed evaluate compared Methods A cross‐sectional was conducted including patients PD healthy controls (HCs). Leukocyte subpopulations NLR were measured blood. Multivariate linear regression post hoc tests applied. Electronic databases searched November 2023 perform meta‐analyses clarify PSP. Results Our cohort included 121 PSP, 127 266 HCs. higher had neutrophil count Whilst lower lymphocyte found HCs, did not between supported this profile. Conclusions show an increased Different pathogenic mechanisms are PD, since altered mainly driven by neutrophils. Understanding neutrophils' role allow for development targeted therapies.

Язык: Английский

Possible Impact of Peripheral Inflammatory Factors and Interleukin-1β (IL-1β) on Cognitive Functioning in Progressive Supranuclear Palsy–Richardson Syndrome (PSP-RS) and Progressive Supranuclear Palsy–Predominant Parkinsonism (PSP-P)

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 13211 - 13211

Опубликована: Дек. 9, 2024

Progressive supranuclear palsy (PSP) is a tauopathic atypical parkinsonian syndrome. Recent studies suggest that inflammation may play role in PSP pathogenesis, highlighting markers like the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), and cytokines such as IL-1β IL-6. This study aimed to assess relationship between peripheral inflammatory psychological abnormalities PSP-RS PSP-P patients. The included 24 participants: 12 with PSP-RS, PSP-P, controls. Cognitive function was assessed using Montreal Assessment (MoCA); however, executive functions were evaluated Frontal Battery (FAB), while IL-1β, IL6, NLR, PLR measured. parameter correlation executed Spearman's (rs). analysis revealed significant negative correlations NLR MoCA (rs = -0.48), well -0.60). statistically but relatively weak. highlights relevance of reflecting cognitive decline patients, potentially playing protective function.

Язык: Английский