Sulfamethizole Attenuates Pentylenetetrazole‐Induced Seizures in Mice via mTOR Inhibition DOI

Lazari Kambli,

Dezaree Raut, Lokesh Kumar Bhatt

и другие.

Drug Development Research, Год журнала: 2024, Номер 86(1)

Опубликована: Дек. 26, 2024

ABSTRACT Epilepsy affects at least 1% of the global population all socioeconomic backgrounds. Data obtained from previous studies suggest role mTOR signaling in epileptogenesis. The present study aimed to investigate hypothesis that inhibitor sulfamethizole might produce antiepileptic effects pentylenetetrazole (PTZ)‐induced kindling seizures mice. For induction kindling, mice were administered 40 mg/kg PTZ on alternate days for 13 days. severity was analyzed using a seizure intensity score. Rotarod performance, actophotometer, and chimney tests performed check muscle coordination locomotor functions. IL‐6 levels measured brain homogenate. Histological analyses done hematoxylin–eosin cresyl violet stains. Sulfamethizole daily 10 50 doses. administration resulted PTZ‐veh group. In addition, group showed decreased fall time rotarod reduced activity, failed tests. also increased brain, along with neuronal degeneration layer cells hippocampus. Treatment significantly ameliorated score, latency duration, coordination, functions compared It downregulated expression significantly. conclusion, activity against PTZ‐induced via inhibition.

Язык: Английский

Febrile Seizures: A Systematic Review of Different Guidelines DOI Creative Commons
Antonio Corsello,

Maria Beatrice Marangoni,

Marina Macchi

и другие.

Pediatric Neurology, Год журнала: 2024, Номер 155, С. 141 - 148

Опубликована: Апрель 3, 2024

BackgroundFebrile seizures (FS) are the most common neurological disorder in pediatric age. They affect 2-12% of children and result from a complex interplay genetic environmental factors. Effective management unambiguous recommendations crucial for allocating healthcare resources efficiently ensuring cost-effectiveness treating FS.MethodsThis systematic review compares existing guidelines to provide insights into FS management. Seven published between 1991 2021, Japan, United Kingdom, States, Mexico, India Italy, were included. Data extraction covered definitions, diagnostic criteria, hospital admission tests, prophylaxis recommendations.ResultsHospital criteria varied but typically included age < 18 months FS. Neuroimaging lumbar puncture varied, with suggesting limited use. Pharmacological was generally discouraged simple considered only high-risk cases, due benign nature potential side effects antiseizure medications.ConclusionGuidelines on exhibit similarities differences, highlighting need standardized improved parental education enhance clinical outcomes reduce economic social costs associated Future research should focus creating updated international their practical implementation.

Язык: Английский

Процитировано

6
Lamotrigine add-on therapy for drug-resistant focal epilepsy DOI
Mariangela Panebianco, Rebecca Bresnahan, Anthony G Marson

и другие.

Cochrane library, Год журнала: 2023, Номер 2023(12)

Опубликована: Дек. 11, 2023

Язык: Английский

Процитировано

10
Intranasal administration of antiseizure drugs using new formulation trends: one step closer to reach clinical trials DOI
Sara Meirinho, Márcio Rodrigues, Gilberto Alves

и другие.

Expert Opinion on Drug Delivery, Год журнала: 2025, Номер unknown

Опубликована: Янв. 18, 2025

Although there are numerous options for epilepsy treatment, its effective control continues unsatisfactory. Thus, search alternative therapeutic to improve the efficacy/safety binomial of drugs becomes very attractive investigate. In this context, intranasal administration antiseizure formulated on state-of-the-art nanosystems can be a promising strategy. This work gives comprehensive overview different developed and evaluated preclinical studies over last 10 years published in 'PubMed' 'Web Science' databases. Additionally, it highlights their pharmaceutical critical quality attributes vivo pharmacological outputs that might infer possible results when transposing clinical trials. Research into optimized encapsulating enhance direct nose-to-brain delivery increased years. Particularly, interest formulating first second generation nanoparticles here highlighted, been demonstrated safety improvement pharmacokinetic efficacy outputs. Still, none them were brought considering existing barriers between trials, if supported by robust targeted design approaches, drug presented as valid superior treatment.

Язык: Английский

Процитировано

0
Edaravone Dexborneol Exerts Anti-epileptic Effects on Rodent Temporal Lobe Epilepsy by Promoting NMDAR Deactivation and Inhibiting Oxidative Stress DOI

Qiu Wan-hua,

Ruge Chen, Lingai Pan

и другие.

Phytomedicine, Год журнала: 2025, Номер 140, С. 156558 - 156558

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Are antiseizure medications disease modifiers? DOI
Louise Tyvaert

Revue Neurologique, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
A Newborn Presenting with Alternating Bradycardia and Tachycardia DOI
Tiago Magalhães, Marisa Bastos Pereira, Renato Silva

и другие.

NeoReviews, Год журнала: 2025, Номер 26(5), С. e342 - e347

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Practical approach to anti seizure medications, an update DOI Creative Commons
Rhys H. Thomas

Clinical Medicine, Год журнала: 2024, Номер 24(2), С. 100040 - 100040

Опубликована: Март 1, 2024

Язык: Английский

Процитировано

1
Initial clinical evidence on biperiden as antiepileptogenic after traumatic brain injury—a randomized clinical trial DOI Creative Commons
Maira Licia Foresti, Eliana Garzón,

Mariana Teichner de Moraes

и другие.

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Авг. 7, 2024

There is currently no efficacious intervention for preventing post-traumatic epilepsy (PTE). Preclinical studies support the potential use of anticholinergics this condition. The purpose study was to evaluate effects biperiden as an PTE. A randomized, double-blinded clinical trial conducted at HC/FMUSP between 2018-2022. Adults with acute traumatic brain injury (TBI) were randomly assigned receive or placebo, 10 days. primary outcome incidence PTE while secondary outcomes included frequency seizures, any adverse events and mortality after 24 months. powered a planned enrolment 132 patients. began in January 2018 halted by researchers on March 2020 (and terminated December 2022) face global COVID-19 pandemic. Overall, 123 participants randomized 112 contributed data modified mITT analysis, being that 61 (49.5%) completed 24-month follow-up consult. Data analysis indicated lack evidence either, (2.6, 95%CI, 0.65-10.57;

Язык: Английский

Процитировано

1
Terminology of medicines used to control seizure disorders: 2024 ILAE Recommendations and profile of real-world term use DOI Creative Commons
Д. В. Блинов, А. С. Петрухин, К. В. Воронкова

и другие.

Epilepsy and Paroxysmal Conditions, Год журнала: 2024, Номер 16(3), С. 176 - 191

Опубликована: Окт. 21, 2024

Background. The International League Against Epilepsy (ILAE) has provided recommendations on the terminology of medicines for control seizure disorders, which should be adapted into different languages. Objective: to evaluate usage profile terms describing effects used in patients with epilepsy. Material and methods. search query analysis systems Google Trends Yandex Wordstat as well PubMed/MEDLINE, Scholar eLibrary databases were general public professional profile, respectively. following Russian English studied: “antiepileptic”, “antiepileptic drug”, “antiseizure”, “antiseizure drug”. In order ascertain a prevailing opinion within patient communities, questionnaire survey was conducted online resources non-profit partnership “The Association Epileptologists Patients” carried out via cloud-based cross-platform social media instant messaging service Telegram platform VK. Results. English-speaking internet segment, term “antiepileptic” is more than 5 times frequently “antiseizure” by public. Conversely, Russian-language almost 2.5 common. prevalent scientific community both segments. This finding aligns observed among epileptologists epilepsy patients. results revealed that 56.42% 179 respondents favor “AED” therapy”, whereas few 17.32% those endorsed ILAE-proposed terminology. Conclusion. light established practice use practicing epileptic patients, differences semantics English- identified lack precision ILAE definition epilepsy, it can concluded Russian-speaking population, are preferable rather medication”, “ASM”. Additionally, “convulsive ictus” “epileptic due negative connotation “seizure” Russian. not regarded mutually exclusive context treatment direct impact course. Finally, necessary further refine classification.

Язык: Английский

Процитировано

1
Movement Termination of Slow-Wave Sleep—A Potential Biomarker? DOI Creative Commons
Yvonne Höller,

Stefanía Guðrún Eyjólfsdóttir,

Matej Rusiňák

и другие.

Brain Sciences, Год журнала: 2024, Номер 14(5), С. 493 - 493

Опубликована: Май 13, 2024

The duration of slow-wave sleep (SWS) is related to the reported quality and important variables mental physical health. internal cues end an episode SWS are poorly understood. One such cue initiation a body movement, which detectable as electromyographic (EMG) activity in sleep-electroencephalography (EEG). In present study, we characterized termination episodes by movement explore its potential biomarker. To this end, relation between occurrence individual characteristics (age, sex), spectral content, chronotype, depression, medication, overnight memory performance, and, neurological application, epilepsy. We analyzed 94 full-night EEG-EMG recordings (75/94 had confirmed epilepsy) video-EEG monitoring unit EpiCARE Centre Salzburg, Austria. Segments were counted rated for their or not through visual inspection continuous EEG EMG recordings. Multiple linear regression was used predict number that ended with type epilepsy (focal, generalized, no epilepsy, unclear), gender, total SWS, seizures during night, tonic-clonic frequency spectra. Furthermore, assessed whether retention. According multiple regression, patients overall longer experienced more (t = 5.64; p 0.001). No other variable proportion including epilepsy-related variable. A small sample (n 4) taking Sertraline significant compared all 8.00; < 0.001) n 35 who did take any medication 4.22; While result based on subsample must be interpreted caution, it warrants replication larger without further elucidate role serve biomarker continuity effects sleep.

Язык: Английский

Процитировано

0