The Major Histocompatibility Complex modulatesBatrachochytrium dendrobatidisandRanavirusinfections in three amphibian species DOI Creative Commons
María Cortázar-Chinarro, Àlex Richter‐Boix, Peter Halvarsson

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Апрель 15, 2023

ABSTRACT Genetic variation of immune genes is an important component genetic diversity. Major histocompatibility complex (MHC) have been put forward as a model for studying how diversity maintained and geographically distributed in wild populations. Pathogen-mediated selection processes (i.e., heterozygosity advantage, rare-allele advantage or fluctuating selection) demography are believed to generate maintain the extreme MHC observed. However, establishing relative importance different proposed mechanisms has proved extremely difficult, but heterozygote expected be more detectable when multiple pathogens considered simultaneously. Here, we test whether three amphibian species ( Ichthyosaura alpestris, Pleurodeles waltl, Pelophylax perezi ) driven by pathogen-mediated selection. We examined relationship between individual class II exon variability with infection status (infected not), intensity, co-infection two main pathogens: Batrachochytrium dendrobatidis Bd Ranavirus sp. Rv ). found higher 2 allelic I.alpestris P. than P.waltl no significant differences allele frequencies groups. also observed intensity infected individuals co-infected depending on number loci that carries. For I. alpestris , show stronger evidence associations carry specific alleles supertypes. Our results suggest association single might provide new insights into host-parasite evolution better understanding evolutionary

Язык: Английский

Influence of Host and Landscape‐Associated Factors in the Infection and Transmission of Pathogens: The Case of Directly Transmitted Virus in Mammals DOI Creative Commons
María del Carmen Villalobos‐Segura, Oscar Rico‐Chávez, Gerardo Suzán

и другие.

Veterinary Medicine and Science, Год журнала: 2024, Номер 11(1)

Опубликована: Дек. 18, 2024

Among pathogens associated with mammals, numerous viruses a direct transmission route impact human, domestic and wild species health. Host landscape factors affect viral infection dynamics of these viruses, along barriers to host dispersal gene exchange. However, studies show biases toward certain locations, hosts detected pathogens, regional variations in similar host-virus associations.

Язык: Английский

Процитировано

0
The Major Histocompatibility Complex modulatesBatrachochytrium dendrobatidisandRanavirusinfections in three amphibian species DOI Creative Commons
María Cortázar-Chinarro, Àlex Richter‐Boix, Peter Halvarsson

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Апрель 15, 2023

ABSTRACT Genetic variation of immune genes is an important component genetic diversity. Major histocompatibility complex (MHC) have been put forward as a model for studying how diversity maintained and geographically distributed in wild populations. Pathogen-mediated selection processes (i.e., heterozygosity advantage, rare-allele advantage or fluctuating selection) demography are believed to generate maintain the extreme MHC observed. However, establishing relative importance different proposed mechanisms has proved extremely difficult, but heterozygote expected be more detectable when multiple pathogens considered simultaneously. Here, we test whether three amphibian species ( Ichthyosaura alpestris, Pleurodeles waltl, Pelophylax perezi ) driven by pathogen-mediated selection. We examined relationship between individual class II exon variability with infection status (infected not), intensity, co-infection two main pathogens: Batrachochytrium dendrobatidis Bd Ranavirus sp. Rv ). found higher 2 allelic I.alpestris P. than P.waltl no significant differences allele frequencies groups. also observed intensity infected individuals co-infected depending on number loci that carries. For I. alpestris , show stronger evidence associations carry specific alleles supertypes. Our results suggest association single might provide new insights into host-parasite evolution better understanding evolutionary

Язык: Английский

Процитировано

0