DNA Methylation Associates With Sex‐Specific Effects of Experimentally Increased Yolk Testosterone in Wild Nestlings
Molecular Ecology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
ABSTRACT
Maternal
hormones
can
profoundly
impact
offspring
physiology
and
behaviour
in
sex‐dependent
ways.
Yet
little
is
known
about
the
molecular
mechanisms
linking
these
maternal
effects
to
phenotypes.
DNA
methylation,
an
epigenetic
mechanism,
suggested
facilitate
androgens'
effects.
To
assess
whether
phenotypic
changes
induced
by
androgens
associate
with
methylation
changes,
we
experimentally
manipulated
yolk
testosterone
levels
wild
great
tit
eggs
(
Parus
major
)
quantified
hatched
offspring.
While
found
no
effect
on
handing
stress
response,
increased
decreased
begging
probability,
emphasised
sex
differences
fledging
mass,
affected
at
763
CpG
sites,
but
always
a
sex‐specific
way.
These
sites
are
associated
genes
involved
growth,
oxidative
stress,
reproduction,
suggesting
trade‐offs
balance
costs
benefits
of
exposure
high
levels.
Future
studies
should
if
extend
beyond
nestling
stage
fitness.
Язык: Английский
Epigenetic Diversity and the Evolutionary Potential of Wild Populations
Evolutionary Applications,
Год журнала:
2024,
Номер
17(10)
Опубликована: Окт. 1, 2024
ABSTRACT
Fast‐paced
selective
pressures
imposed
by
climate
change
and
anthropogenic
activities
call
for
adaptive
evolutionary
responses
to
emerge
at
ecological
timescales.
However,
the
evolution
heritability
of
genomic
variation
underlie
mechanistic
constraints,
which
dictate
a
slower
pace
adaptation
exclusively
relying
on
standing
genetic
novel
mutations.
Environmentally
responsive
epigenetic
mechanisms
can
allow
acclimatisation
phenotypes
arise
faster
than
DNA
sequence‐based
alone.
Nevertheless,
knowledge
gap
between
identifying
marks
effectively
deeming
them
functional
is
still
wide
in
natural
context
often
outside
scope
model
organisms.
With
this
Special
Issue,
we
aimed
narrow
presenting
compilation
original
research
articles,
reviews
opinions
topic
epigenetics
wild
populations.
We
contextualised
collection
within
overarching
conservation
biology,
as
firmly
propose
that
significantly
enhance
effectiveness
measures.
Contributions
highlighted
putative
role
potential
species
populations
directly
indirectly
affected
climatic
shifts
actions.
They
further
exemplified
how
be
used
biomarkers
monitoring
variations
physiology,
phenology
behaviour.
Lastly,
perspective
articles
illustrated
past
present
while
suggesting
future
avenues.
Язык: Английский
DNA methylation associates with sex-specific effects of experimentally increased yolk testosterone in wild nestlings
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 12, 2024
Abstract
Maternal
hormones
can
profoundly
impact
offspring
physiology
and
behaviour
in
sex-dependent
ways.
Yet
little
is
known
on
the
molecular
mechanisms
linking
these
maternal
effects
to
phenotypes.
DNA
methylation,
an
epigenetic
mechanism,
suggested
facilitate
androgens’
effects.
To
assess
whether
phenotypic
changes
induced
by
androgens
associate
with
methylation
changes,
we
experimentally
manipulated
yolk
testosterone
levels
wild
great
tit
eggs
(
Parus
major
)
quantified
hatched
offspring.
Increased
decreased
begging
probability,
emphasised
sex-differences
fledging
mass
affected
at
763
CpG
sites,
but
always
a
sex-specific
way.
These
sites
associated
genes
involved
growth,
oxidative
stress
reproduction,
suggesting
trade-offs
balance
costs
benefits
of
exposure
high
levels.
Future
studies
should
if
extend
beyond
nestling
stage
fitness.
Язык: Английский