Conservation Mitonuclear Replacement: Facilitated mitochondrial adaptation for a changing world
Evolutionary Applications,
Год журнала:
2024,
Номер
17(3)
Опубликована: Март 1, 2024
Abstract
Most
species
will
not
be
able
to
migrate
fast
enough
cope
with
climate
change,
nor
evolve
quickly
current
levels
of
genetic
variation.
Exacerbating
the
problem
are
anthropogenic
influences
on
adaptive
potential,
including
prevention
gene
flow
through
habitat
fragmentation
and
erosion
diversity
in
small,
bottlenecked
populations.
Facilitated
adaptation,
or
assisted
evolution,
offers
a
way
augment
variation
via
artificial
selection,
induced
hybridization,
engineering.
One
key
source
variation,
particularly
for
climatic
core
metabolic
genes
encoded
by
mitochondrial
genome.
These
influence
environmental
tolerance
heat,
drought,
hypoxia,
but
must
interact
intimately
co‐evolve
suite
important
nuclear
genes.
coadapted
mitonuclear
form
some
reproductive
barriers
between
species.
Mitochondrial
genomes
can
do
introgress
an
manner,
they
may
co‐introgress
maintaining
compatibility.
Managers
should
consider
relevance
variability
conservation
decision‐making,
as
tool
facilitating
adaptation.
I
propose
novel
technique
dubbed
Conservation
Mitonuclear
Replacement
(CmNR),
which
entails
replacing
machinery
threatened
species—the
genome
loci—with
those
from
closely
related
divergent
population,
better‐adapted
changes
carry
lower
load.
The
most
feasible
route
CmNR
is
combine
CRISPR‐based
editing
replacement
technologies.
This
method
preserves
much
organism's
phenotype
could
allow
populations
persist
wild
when
no
other
suitable
options
exist.
mountaintops,
where
rising
temperatures
threaten
alarming
number
almost
certain
extinction
next
century.
Язык: Английский
The Complexities of Interspecies Somatic Cell Nuclear Transfer: From Biological and Molecular Insights to Future Perspectives
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3310 - 3310
Опубликована: Апрель 2, 2025
For
nearly
three
decades,
interspecies
somatic
cell
nuclear
transfer
(iSCNT)
has
been
explored
as
a
potential
tool
for
cloning,
regenerative
medicine,
and
wildlife
conservation.
However,
developmental
inefficiencies
remain
major
challenge,
largely
due
to
persistent
barriers
in
nucleocytoplasmic
transport,
mitonuclear
communication,
epigenome
crosstalk.
This
review
synthesized
peer-reviewed
English
articles
from
PubMed,
Web
of
Science,
Scopus,
spanning
using
relevant
keywords
explore
the
molecular
mechanisms
underlying
iSCNT
improvement
strategies.
We
highlight
recent
findings
deepening
understanding
iSCNT,
emphasizing
their
interconnected
complexities,
including
following:
(1)
incompatibility
may
disrupt
pore
complex
(NPC)
assembly
maturation,
impairing
transport
essential
transcription
factors
(TFs),
embryonic
genome
activation
(EGA),
reprogramming;
(2)
could
lead
mitochondrial
DNA
(nDNA-mtDNA)
mismatches,
affecting
electron
chain
(ETC)
assembly,
oxidative
phosphorylation,
energy
metabolism;
(3)
these
interrelated
incompatibilities
can
further
influence
epigenetic
regulation,
potentially
leading
incomplete
reprogramming
embryos.
Addressing
challenges
requires
multifaceted,
species-specific
approach
that
balances
multiple
rather
than
isolating
single
factor.
Gaining
insight
into
interactions
between
donor
nucleus
recipient
cytoplast,
coupled
with
optimizing
strategies
tailored
specific
pairings,
significantly
enhance
efficiency,
ultimately
transforming
experimental
breakthroughs
real-world
applications
reproductive
biotechnology,
species
Язык: Английский
An evolving roadmap: using mitochondrial physiology to help guide conservation efforts
Conservation Physiology,
Год журнала:
2024,
Номер
12(1)
Опубликована: Янв. 1, 2024
Abstract
The
crucial
role
of
aerobic
energy
production
in
sustaining
eukaryotic
life
positions
mitochondrial
processes
as
key
determinants
an
animal's
ability
to
withstand
unpredictable
environments.
advent
new
techniques
facilitating
the
measurement
function
offers
increasingly
promising
tool
for
conservation
approaches.
Herein,
we
synthesize
current
knowledge
on
links
between
bioenergetics,
ecophysiology
and
local
adaptation,
expanding
them
wider
physiology
field.
We
discuss
recent
findings
linking
cellular
bioenergetics
whole-animal
fitness,
context
climate
change.
summarize
topics,
questions,
methods,
pitfalls
caveats
help
provide
a
comprehensive
roadmap
studying
mitochondria
from
perspective.
Our
overall
aim
is
guide
natural
populations,
outlining
methods
that
could
be
most
useful
assess
Язык: Английский
Toward the Development of the Trojan Female Technique in Pest Insects: Male‐Specific Influence of Mitochondrial Haplotype on Reproductive Output in the Seed Beetle Acanthoscelides obtectus
Vlajnić Lea,
Savković Uroš,
Jović Jelena
и другие.
Evolutionary Applications,
Год журнала:
2024,
Номер
17(12)
Опубликована: Дек. 1, 2024
ABSTRACT
Biocontrol
techniques
that
impair
reproductive
capacity
of
insect
pests
provide
opportunities
to
control
the
dynamics
their
populations
while
minimizing
collateral
damage
non‐target
species
and
environment.
The
Trojan
Female
Technique,
or
TFT,
is
a
method
trans‐generational
fertility‐based
population
through
release
females
carry
mitochondrial
DNA
mutations
negatively
affect
male,
but
not
female,
output.
TFT
based
on
evolutionary
hypothesis
that,
due
maternal
inheritance
mitochondria,
which
are
beneficial
neutral
in
harmful
males
can
accumulate
genome
without
selection
acting
against
them.
Although
has
been
theoretically
substantiated,
empirical
work
date
focused
only
Drosophila
melanogaster
populations,
existence
male‐biased
approach
economically
important
pest
remain
unexplored.
Here,
we
examined
sex‐specific
effects
three
distinct
naturally
occurring
haplotypes
(MG1a,
MG1d,
MG3b)
several
life
history
traits
seed
beetle
Acanthoscelides
obtectus
.
Our
results
revealed
harboring
MG3b
mitotype
exhibited
lower
early
fecundity
fertility,
there
were
no
longevity
either
sex.
experiments
support
for
variant
specifically
impairs
male
output
insects.
These
be
harnessed
further
develop
as
novel
form
biocontrol
with
broad
applicability
economic
disease
vector
Язык: Английский