Oncogenic processes: a neglected parameter in the evolutionary ecology of animals DOI Creative Commons

Frédéric Thomas,

Klara Asselin,

Nick MacDonald

и другие.

Comptes Rendus Biologies, Год журнала: 2024, Номер 347(G1), С. 137 - 157

Опубликована: Ноя. 7, 2024

Cancer is a biological process that emerged at the end of Precambrian era with rise multicellular organisms. Traditionally, cancer has been viewed primarily as disease relevant to human and domesticated animal health, attracting attention mainly from oncologists. In recent years, however, community ecologists evolutionary biologists recognized pivotal role cancer-related issues in paths various species, influencing multiple facets their biology. It become evident overlooking these untenable for comprehensive understanding species evolution ecosystem functioning. this article, we highlight some significant advancements field, also underscoring pressing need consider reciprocal interactions not only between cells hosts but all entities comprising holobiont. This reflection gains particular relevance ecosystems face increasing pollution mutagenic substances, resulting resurgence cases wildlife. Le est un processus biologique qui émergé à la fin de l'ère précambrienne avec l'apparition des organismes multicellulaires. Traditionnellement, le été principalement perçu comme une maladie touchant santé humaine et celle animaux domestiques, attirant l'attention oncologues. Cependant, ces dernières années, communauté écologistes biologistes évolutionnistes reconnu rôle central questions liées au dans les trajectoires évolutives diverses espèces, influençant multiples aspects leur biologie. Il devenu évident que négliger enjeux intenable pour compréhension exhaustive l'évolution espèces du fonctionnement écosystèmes. Dans cet nous mettons en lumière certaines avancées significatives ce domaine, soulignant également nécessité pressante considérer réciproques non seulement entre cellules cancéreuses leurs hôtes, mais aussi toutes entités constituant l'holobionte. Cette réflexion prend pertinence particulière alors écosystèmes sont confrontés croissante par substances mutagènes, entraînant résurgence cas faune sauvage.

Ecology of vertical tumor transmission in the freshwater cnidarian Hydra oligactis DOI Creative Commons

Nikita Stepanskyy,

Michel Pascal,

Klara Asselin

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

0
The widespread vulnerability of Hydra oligactis to tumourigenesis confirms its value as a model for studying the effects of tumoural processes on the ecology and evolution of species DOI Creative Commons
Antoine M. Dujon, Justine Boutry, Sophie Tissot

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 951, С. 175785 - 175785

Опубликована: Авг. 24, 2024

Tumoural processes, ubiquitous phenomena in multicellular organisms, influence evolutionary trajectories of all species. To gain a holistic understanding their impact on species' biology, suitable laboratory models are required. Such characterised by widespread availability, ease cultivation, and reproducible tumour induction. It is especially important to explore, through experimental approaches, how tumoural processes alter ecosystem functioning. The cnidarian Hydra oligactis currently emerging as promising model due its development both transmissible non-transmissible tumours the wide breadth experiments that can be conducted with this species (at individual, population, mechanistic, levels). However, hydras are, so far, only documented Europe, it not clear if phenomenon local or widespread. In study we demonstrate Australian from two independent river networks develop consisting interstitial stem cells display phenotypic alterations (supernumerary tentacles) akin European counterparts. This finding confirms value for ecological research host-tumour interactions. • Tumoral biology dynamics There need good context increased oncogenic pressures We show has geographical vulnerabilities tumorigenesis thus great effect functioning discuss implications using future comparative studies

Язык: Английский

Процитировано

1
Cancer and One Health: tumor-bearing individuals can act as super spreaders of symbionts in communities DOI Creative Commons
Sophie Tissot,

Jordan Meliani,

Matthew Chee

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 11, 2024

Recent theoretical advances in the One Health approach have suggested that cancer pathologies should be given greater consideration, as cancers often render their hosts more vulnerable to infectious agents, which could turn them into super spreaders within ecosystems. Although biologically plausible, this hypothesis has not yet been validated experimentally. Using a community of cnidarians Hydra genus (Hydra oligactis, viridissima, vulgaris) and commensal ciliate species (Kerona pediculus) colonizes them, we tested whether tumoral polyps H. compared healthy ones, played an amplifying role number ciliates, potentially resulting higher likelihood infection for other members through spillovers. Our results indicate K. pediculus proliferation rate on oligactis than infestation hydras. However, magnitude spillover differed between recipient species. This study provides our knowledge first elements proof concept individuals communities act symbionts species, thus affect biotic interactions dynamics

Язык: Английский

Процитировано

1
Beyond Peto’s Paradox: Expanding the Study of Cancer Resistance Across Species DOI Creative Commons
Antoine M. Dujon,

Amy M. Boddy,

Rodrigo Hamede

и другие.

Evolution, Год журнала: 2024, Номер 79(1), С. 6 - 10

Опубликована: Ноя. 4, 2024

Abstract Peto’s paradox, which highlights the lower-than-expected cancer rates in larger and/or longer-lived species, is a cornerstone of discussions at intersection ecology, evolution, and research. It prompts investigations into how species with traits that theoretically increase risk manage to exhibit resistance, ultimate goal uncovering novel therapies for humans. Building on these foundational insights, we propose expanding research focus that, despite possessing beyond size longevity their risk, unexpected resistance. Testing paradox without interference from transient dynamics also requires considering are an equilibrium between risks defenses, increasingly challenging due anthropogenic activities. Additionally, argue transmissible cancers could significantly help understanding metastatic process might be naturally suppressed. This perspective timely aims support continued in-depth identification anti-cancer adaptations retained throughout evolution animal kingdom.

Язык: Английский

Процитировано

0
Oncogenic processes: a neglected parameter in the evolutionary ecology of animals DOI Creative Commons

Frédéric Thomas,

Klara Asselin,

Nick MacDonald

и другие.

Comptes Rendus Biologies, Год журнала: 2024, Номер 347(G1), С. 137 - 157

Опубликована: Ноя. 7, 2024

Cancer is a biological process that emerged at the end of Precambrian era with rise multicellular organisms. Traditionally, cancer has been viewed primarily as disease relevant to human and domesticated animal health, attracting attention mainly from oncologists. In recent years, however, community ecologists evolutionary biologists recognized pivotal role cancer-related issues in paths various species, influencing multiple facets their biology. It become evident overlooking these untenable for comprehensive understanding species evolution ecosystem functioning. this article, we highlight some significant advancements field, also underscoring pressing need consider reciprocal interactions not only between cells hosts but all entities comprising holobiont. This reflection gains particular relevance ecosystems face increasing pollution mutagenic substances, resulting resurgence cases wildlife. Le est un processus biologique qui émergé à la fin de l'ère précambrienne avec l'apparition des organismes multicellulaires. Traditionnellement, le été principalement perçu comme une maladie touchant santé humaine et celle animaux domestiques, attirant l'attention oncologues. Cependant, ces dernières années, communauté écologistes biologistes évolutionnistes reconnu rôle central questions liées au dans les trajectoires évolutives diverses espèces, influençant multiples aspects leur biologie. Il devenu évident que négliger enjeux intenable pour compréhension exhaustive l'évolution espèces du fonctionnement écosystèmes. Dans cet nous mettons en lumière certaines avancées significatives ce domaine, soulignant également nécessité pressante considérer réciproques non seulement entre cellules cancéreuses leurs hôtes, mais aussi toutes entités constituant l'holobionte. Cette réflexion prend pertinence particulière alors écosystèmes sont confrontés croissante par substances mutagènes, entraînant résurgence cas faune sauvage.

Процитировано

0