Current Dermatology Reports, Год журнала: 2024, Номер 13(2), С. 67 - 84
Опубликована: Март 14, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3303 - 3303
Опубликована: Март 14, 2024
Mitochondria are eukaryotic cellular organelles that function in energy metabolism, ROS production, and programmed cell death. Cutaneous epithelial hair follicle dermal papilla cells energy-rich thereby may be affected by mitochondrial dysfunction DNA mutation accumulation. In this review, we aimed to summarize the medical literature assessing dermatologic conditions outcomes associated with dysfunction. A search of PubMed Embase was performed subsequent handsearching retrieve additional relevant articles. Mitochondrial (mtDNA) deletions, accumulation, damage phenotypic signs cutaneous aging, loss, impaired wound healing. addition, several aberrant activity, such as systemic lupus erythematosus, psoriasis, vitiligo, atopic dermatitis. Mouse model studies have better established causality between outcomes, some depicting reversibility upon restoration function. mediates a variety conditions, components promising target for therapeutic strategies.
Язык: Английский
Процитировано
13
The EPMA Journal, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Association of both intrinsic and extrinsic risk factors leading to accelerated skin ageing is reflected in excessive ROS production ir/reversible mitochondrial injury burnout, as abundantly demonstrated by accumulating research data. Due the critical role stress pathophysiology disorders, maintained (primary care) restored (secondary health, rejuvenation homoeostasis are considered most effective holistic approach advance dermatological treatments based on systemic health-supportive stimulating measures. Per evidence, an anti-ageing protection, wound healing scarring quality - all strongly depend sustainable functionality well-balanced homoeostasis. The latter can be objectively measured and, if necessary, a manner pre- rehabilitation algorithms tailored individualised patient profiles. entire spectrum corresponding innovations area includes natural rejuvenation, aesthetic reconstructive medicine, protection targeted disorders. Contextually, mitochondria-centric dermatology instrumental for advanced 3PM-guided which makes good use predictive multi-level diagnostics against health-to-disease transition progression relevant Cost-effective new treatment avenues focused health physiologic proposed article including in-depth analysis cases exemplified care with detailed mechanisms expert recommendations presented.
Язык: Английский
Процитировано
2
Frontiers in Physiology, Год журнала: 2023, Номер 14
Опубликована: Ноя. 15, 2023
Aging of human skin is a complex process leading to decline in homeostasis and regenerative potential this tissue. Mitochondria are important cell organelles that have crucial role several cellular mechanisms such as energy production free radical maintenance. However, mitochondrial metabolism well processes dynamics, biogenesis, degradation varies considerably among the different types cells populate skin. Disturbed function known promote aging inflammation skin, impairment physiological onset pathologies. In review, we discuss essential mitochondria how morphology, physiology, each these compartments contributes aging.
Язык: Английский
Процитировано
14
Antioxidants and Redox Signaling, Год журнала: 2024, Номер 41(10-12), С. 744 - 768
Опубликована: Янв. 6, 2024
Significance: Metabolic syndrome (MetS) has become a major global public health problem and there is an urgent need to elucidate its pathogenesis find more effective targets modalities for intervention.
Язык: Английский
Процитировано
6
Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)
Опубликована: Апрель 8, 2025
Язык: Английский
Процитировано
0
Journal of Investigative Dermatology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Clinical Cosmetic and Investigational Dermatology, Год журнала: 2025, Номер Volume 18, С. 1281 - 1295
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2024, Номер 13(6), С. 670 - 670
Опубликована: Май 30, 2024
Background: Lichen planus (LP) is a chronic inflammatory skin disease of unelucidated etiology. LP immunopathogenesis mainly governed by cytotoxic T lymphocytes that mediate an immune response in basal keratinocytes, which may transform into reservoir antigens able to initiate autoimmune reaction. However, other pathogenic pathways complement these mechanisms. Recent studies highlight the involvement nitrosative stress pathogenesis diseases. Current data on its role are scarce. Methods: In this article, we investigated 40 cutaneous (CLP) patients compared healthy subjects using serum markers including markers—direct nitrite, total nitrate and symmetric dimethylarginine (SDMA), antioxidant status (TAS), hsCRP, marker inflammation, analyzed relationship between stress, defense, inflammation offer new insights NO pathway pathogenesis. Results: We identified significantly higher levels direct nitrate, SDMA lower TAS CLP versus controls. There were significant negative correlations significantl positive hsCRP with CLP. Conclusion: Our results indicate increased level correlates pro-inflammatory altered defense.
Язык: Английский
Процитировано
2
Journal of Investigative Dermatology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1
Current Dermatology Reports, Год журнала: 2024, Номер 13(2), С. 67 - 84
Опубликована: Март 14, 2024
Язык: Английский
Процитировано
0