Cannabinoids in Integumentary Wound Care: A Systematic Review of Emerging Preclinical and Clinical Evidence

Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 1081 - 1081

Опубликована: Авг. 17, 2024

This systematic review critically evaluates preclinical and clinical data on the antibacterial wound healing properties of cannabinoids in integument wounds. Comprehensive searches were conducted across multiple databases, including CINAHL, Cochrane library, Medline, Embase, PubMed, Web Science, LILACS, encompassing records up to May 22, 2024. Eighteen studies met inclusion criteria. Eleven animal studies, predominantly utilizing murine models (

Язык: Английский

Cannabinoids as Antibacterial Agents: A Systematic and Critical Review of In Vitro Efficacy Against Streptococcus and Staphylococcus

Antibiotics, Год журнала: 2024, Номер 13(11), С. 1023 - 1023

Опубликована: Окт. 30, 2024

Background: Two major bacterial pathogens, Staphylococcus aureus and Streptococcus pyogenes, are becoming increasingly antibiotic-resistant. Despite the urgency, only a few new antibiotics have been approved to address these infections. Although cannabinoids noted for their antibacterial properties, comprehensive review of effects on bacteria has lacking. Objective: This systematic examines activity against S. aureus, including methicillin-resistant (MRSA) vancomycin-resistant (VRSA) strains, pyogenes. Methods: Databases, CINAHL, Cochrane, Medline, Scopus, Web Science, LILACS, were searched. Of 3510 records, 24 studies met inclusion criteria, reporting minimum inhibitory concentration (MIC) bactericidal cannabinoids. Results: Cannabidiol (CBD) emerged as most effective cannabinoid, with MICs ranging from 0.65 32 mg/L 0.5 4 MRSA, 1 2 VRSA. Other cannabinoids, such cannabichromene, cannabigerol (CBG), delta-9-tetrahydrocannabinol (Δ9-THC), also exhibited significant antistaphylococcal activity. CBD, CBG, Δ9-THC showed efficacy between 0.6 50 mg/L. Synergistic observed when CBD essential oils Cannabis sativa combined other agents. Conclusion: Cannabinoids’ potency is closely linked structure–activity relationships, features like monoterpene region, aromatic alkyl side chain, carboxylic groups enhancing efficacy, particularly in its cyclic forms. These results highlight potential developing therapies resistant though further research needed confirm clinical effectiveness.

Язык: Английский

The endocannabinoid anandamide prevents TH17 programming of activated T lymphocytes while preserving TH1 responses

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 20, 2024

Anandamide (AEA) is an endocannabinoid that has recently been recognized as a regulator of various inflammatory diseases well cancer. While AEA was thought to predominantly engage cannabinoid (CB) receptors, recent findings suggest that, given its protective anti-inflammatory role in pathological conditions, anandamide may not only CB receptors.

Язык: Английский