Food Bioscience, Год журнала: 2024, Номер unknown, С. 105775 - 105775
Опубликована: Дек. 1, 2024
Язык: Английский
Process Biochemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Mechanisms of Ageing and Development, Год журнала: 2025, Номер unknown, С. 112038 - 112038
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Regenerative Engineering and Translational Medicine, Год журнала: 2025, Номер unknown
Опубликована: Фев. 12, 2025
Язык: Английский
Процитировано
0
Cosmetics, Год журнала: 2025, Номер 12(2), С. 43 - 43
Опубликована: Март 3, 2025
Advanced glycation end products (AGEs) formed via reactions negatively impact skin health by diminishing barrier function and elasticity causing dullness. This study systematically evaluated the inhibitory degradative capabilities of 24 cosmetic ingredients against AGEs using BSA-glucose ELISA-based screening systems. We identified 21 that inhibit fluorescent AGEs, 22 degrade AGEs-collagen crosslinks, 19 with both properties. Further investigation six key ingredients, including freeze-dried Rosa rugosa powder (Rosa cv. Plena) Camellia sinensis flower (Camellia (L.) O. Kuntze), revealed their notable ability to monomers dimers. Freeze-dried achieved a 19% inhibition rate in an MGO-induced HDFs model. Our findings provide valuable insights for selecting anti-glycation agents developing effective products.
Язык: Английский
Процитировано
0
The International Journal of Lower Extremity Wounds, Год журнала: 2025, Номер unknown
Опубликована: Март 25, 2025
Charcot osteoarthropathy (CO) is an unusual and frequently misdiagnosed complication of diabetes mellitus. The delayed diagnosis can have severe consequences for patients’ limb life. Its based firstly in its clinical suspicion, mainly confirmed by imaging tests, like magnetic resorance imaging. Specific biomarkers early detection therapy not been found yet. understanding CO pathogenesis measurement molecules involved this head to direction. purpose review summarize/describe the most current studies measuring people with CO. Confocal corneal microscopy (CCM), inflammatory markers including IL-1, IL-6 TNF-a, bone metabolism RANK, RANKL, OPG, advanced glycation end products (AGEs) mineral density (BMD) were among popular ones included a large number last 20 years significant different levels above comparing non-Charcot groups. Future larger lead discovery novel prompt special entity at stage.
Язык: Английский
Процитировано
0
Food Chemistry X, Год журнала: 2025, Номер unknown, С. 102416 - 102416
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2025, Номер 14(4), С. 392 - 392
Опубликована: Март 26, 2025
Glycation is a process in which reducing sugars bind to proteins, resulting the formation of advanced glycation end products (AGEs). These AGEs accumulate skin, promote excessive collagen crosslinking, and disrupt extracellular matrix (ECM), impairing normal cellular functions contributing skin aging. To evaluate anti-glycation efficacy lotus stamen extract (LSE), we employed BSA–fructose system high glucose (HG)-induced fibroblast model. The results demonstrated that LSE effectively inhibited also exhibited anti-inflammatory, antioxidative, anti-senescent effects HG-induced human fibroblasts (HSF). Further investigation into mechanism component analysis ethyl acetate (LSEE) led identification 15 flavonoids. indicated these flavonoids are likely primary active constituents LSE. Mechanistic studies revealed GLO1 plays crucial role resistance glycation, LSEE enhanced expression through Nrf2/Keap1 pro-survival pathway, thereby mitigating intracellular AGE production. In summary, its multiple flavonoid components exhibit potent activity present significant potential be developed as natural organic product for cosmetic healthcare applications.
Язык: Английский
Процитировано
0
Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111182 - 111182
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143320 - 143320
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2025, Номер 14(4), С. 498 - 498
Опубликована: Апрель 20, 2025
Advanced glycation end-products (AGEs) cause blood vessel damage and induce diabetic complications in various organs, such as the eyes, kidneys, nerves, skin. As stress causes aesthetic, physical, functional changes skin, glycation-targeting skin anti-aging strategies are attracting attention cosmetology dermatology. The primary goal of this review is to understand significance glycation-induced aging examine therapeutic potential strategies. This study covers experimental clinical studies exploring interventions attenuate aging. Glycation decreases viability cells culture media, cell-mediated contraction collagen lattices reconstructed models, expression fibrillin-1 at dermo-epidermal junction explants. It also increases cross-links tail tendon animals, prolonging its breakdown time. However, these attenuated by several synthetic natural agents. Animal have shown that dietary or topical administration agents with antiglycation antioxidant activity can AGE levels (measured autofluorescence) parameters (e.g., color, wrinkles, elasticity, hydration, dermal density) induced chronological aging, diabetes, high-carbohydrate diets, ultraviolet radiation, oxidative stress. Therefore, accumulating evidence supports supplements formulations containing one more may help mitigate AGEs.
Язык: Английский
Процитировано
0