Опубликована: Янв. 1, 2024
Язык: Английский
Geriatrics and gerontology international/Geriatrics & gerontology international, Год журнала: 2023, Номер 23(7), С. 558 - 564
Опубликована: Июнь 14, 2023
The present study aimed to develop a pharmacological evidence-based anticholinergic burden scale (ABS) through direct assessment of muscarinic receptor-binding activities 260 medications commonly used in older adults.
Язык: Английский
Процитировано
9
Geriatrics and gerontology international/Geriatrics & gerontology international, Год журнала: 2023, Номер 24(S1), С. 81 - 87
Опубликована: Окт. 23, 2023
Older adults frequently have many systemic diseases that require treatment with multiple drugs, and thus anticholinergic adverse effect by polypharmacy is a significant concern in the management of older adults. The accuracy burden rating may be increased considering pharmacokinetic pharmacodynamic factors such as biophase drug concentrations, pharmacologically active metabolites formed after administration, muscarinic receptor‐mediated effects. Therefore, pharmacological evidence‐based scale considers expected to more optimal tool for precisely assessing burden, specifically risk reductions events poly‐medicated elderly. Geriatr Gerontol Int 2024; 24: 81–87 .
Язык: Английский
Процитировано
8
Geriatrics and gerontology international/Geriatrics & gerontology international, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Background Anticholinergic burden, reflecting the cumulative impact of medications with anticholinergic properties, significantly predicts adverse drug reactions and geriatric syndromes in older adults. Although risk scales (ARS) have been developed validated various countries, none tailored specifically for Japan. The Japanese Risk Scale (JARS) was to adapt existing ARS frameworks context, considering unique medication profiles cultural factors. Process First, a systematic review performed follow protocol registered PROSPERO (CRD42017076510). A PubMed search from October 2017 March 2023 conducted identify publications post‐September 2017. Based on two algorithms, average scores were used develop JARS. Delphi method, an expert consensus approach, applied determine that not established by algorithms. Sixteen articles identified our contributed JARS development. categorizes 158 into three potency groups: 37 drugs scored as 3 (strong), 27 2 (moderate), 94 1 (weak). Conclusion JARS, newly ARS, could be critical tool burden assessment populations. Developed through Delphi‐based consensus, it encompasses medications, offering comprehensive assessment. Future studies updates should improve accuracy clinical applicability this scale. Geriatr Gerontol Int 2024; ••: ••–•• .
Язык: Английский
Процитировано
1
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Авг. 6, 2024
The use of anticholinergic drugs has been associated with adverse health outcomes. However, their effects cannot be completely separated from the general polypharmacy using standard methods. objective this study was to explore extent which detrimental attributed burden measured by scales (ABS) were distinct those polypharmacy. We compared observed ABS against simulated generated pseudoscales intended measure UK Biobank primary care data. randomly sampled 525 and non-anticholinergic prescribed in year 2015 ~200,000 participants an average age 65 years. then created 1,000 pseudoscales, score designed represent strength background effect polypharmacy, differentiating constructed capture either or putative exhibiting similar distributional properties 23 real-world (statistical equivalence). performed individual logistic regressions for each scale estimate associations between respectively, risk death, dementia, delirium. Across outcomes, odds ratios anticholinergic-polypharmacy on 0.03-0.05 greater than general-polypharmacy pseudoscales. number composing correlated size both (r=~0.5, p<0.001) (r=~0.7, p<0.001). In total, 50-90% showed stronger majority exhibited studied outcomes would expected alone (range differences ratios: -0.05 0.20). Most existing more variance association delirium alone, but varying degrees strength.
Язык: Английский
Процитировано
0
Basic & Clinical Pharmacology & Toxicology, Год журнала: 2024, Номер 135(4), С. 451 - 463
Опубликована: Сен. 1, 2024
Abstract Several medications are commonly administered to older Japanese patients. Since some of them have not been included in previously developed scales estimate the anticholinergic burden, we a new muscarinic receptor binding‐based burden scale. This study aimed investigate functional inhibitory effects 60 medications, classified as 3 and 2 by scale, on receptor‐mediated contractions bladder ileum. The relaxation response induced these drugs isolated rat bladders ileum smooth muscles constricted carbachol was assessed using organ bath method. All inhibited muscle contractile responses activation concentration‐dependent manner Notably, variations were observed drugs, function EC 50 values positively correlated with binding IC results this provide pharmacological evidence for Implementation scale may help reduce risk constipation urinary retention, which common side associated drugs.
Язык: Английский
Процитировано
0
Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics, Год журнала: 2024, Номер 61(3), С. 256 - 270
Опубликована: Июль 25, 2024
Язык: Английский
Процитировано
0
Expert Opinion on Drug Safety, Год журнала: 2024, Номер unknown, С. 1 - 10
Опубликована: Сен. 11, 2024
Antimuscarinics are often the first-choice medications used to treat overactive bladder (OAB), a condition that increasingly affects aging population. However, concerns regarding their potential impact on cognitive function have persisted for more than decade.
Язык: Английский
Процитировано
0
Research in Social and Administrative Pharmacy, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0