RAD18‐ and BRCA1‐dependent pathways promote cellular tolerance to the nucleoside analog ganciclovir DOI Creative Commons
Tasnim Ahmad, Ryotaro Kawasumi, Kouji Hirota

и другие.

Genes to Cells, Год журнала: 2024, Номер 29(11), С. 935 - 950

Опубликована: Авг. 22, 2024

Ganciclovir (GCV) is a clinically important drug as it used to treat viral infections. GCV incorporated into the DNA during replication, where interferes with subsequent replication on GCV-incorporated templates. However, effects of host genome and mechanisms underlying cellular tolerance remain unclear. In this study, we explored these using collection mutant DT40 cells. We identified RAD17

Язык: Английский

Functional Toxicology: Key Concepts and Applications DOI
Chan Kim, Chris D. Vulpe

Elsevier eBooks, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
RAD18‐ and BRCA1‐dependent pathways promote cellular tolerance to the nucleoside analog ganciclovir DOI Creative Commons
Tasnim Ahmad, Ryotaro Kawasumi, Kouji Hirota

и другие.

Genes to Cells, Год журнала: 2024, Номер 29(11), С. 935 - 950

Опубликована: Авг. 22, 2024

Ganciclovir (GCV) is a clinically important drug as it used to treat viral infections. GCV incorporated into the DNA during replication, where interferes with subsequent replication on GCV-incorporated templates. However, effects of host genome and mechanisms underlying cellular tolerance remain unclear. In this study, we explored these using collection mutant DT40 cells. We identified RAD17

Язык: Английский

Процитировано

2