Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases

Frontiers in Pharmacology, Год журнала: 2021, Номер 12

Опубликована: Май 13, 2021

Psychiatric disorders are frequently encountered in many neurological disorders, such as Alzheimer’s and Parkinson diseases along with epilepsy, migraine, essential tremors, stroke. The most common comorbid diagnoses depression anxiety cognitive impairment. Whether the underlying reason is due to neurochemical mechanisms or loss of previous functioning level, comorbidities often overlooked. Various treatment options available, pharmacological treatments, cognitive-behavioral therapy, somatic interventions, electroconvulsive therapy. However oral antidepressant therapy may have some disadvantages, interaction other medications, low tolerability side effects, efficiency. Natural compounds plant origin extensively researched find a better safer alternative treatment. Experimental studies shown that phytochemicals alkaloids, terpenes, flavonoids, phenolic acids well lipids significant potential vitro vivo models psychiatric disorders. In this review, various efficacy natural products on neuroprotective their roles examined neuro-therapeutic potentials shed light.

Язык: Английский

---

Advances and Perspectives in Tissue Culture and Genetic Engineering of Cannabis

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(11), С. 5671 - 5671

Опубликована: Май 26, 2021

For a long time, Cannabis sativa has been used for therapeutic and industrial purposes. Due to its increasing demand in medicine, recreation, industry, there is dire need apply new biotechnological tools introduce genotypes with desirable traits enhanced secondary metabolite production. Micropropagation, conservation, cell suspension culture, hairy root polyploidy manipulation, Agrobacterium-mediated gene transformation have studied cannabis. However, some obstacles such as the low rate of transgenic plant regeneration efficiency production culture restricted application these approaches In current review, vitro genetic engineering methods cannabis along other promising techniques morphogenic genes, computational approaches, clustered regularly interspaced short palindromic repeats (CRISPR), CRISPR/Cas9-equipped genome editing, that can help improve regeneration, well enhance production, highlighted discussed.

Язык: Английский

---

Cannabis-based medicines and pain: a review of potential synergistic and entourage effects

Pain Management, Год журнала: 2021, Номер 11(4), С. 395 - 403

Опубликована: Март 11, 2021

The recent legalization of medicinal cannabis in several jurisdictions has spurred the development therapeutic formulations for chronic pain. Unlike pure delta-9-tetrahydrocannabinol (THC), full-spectrum products contain naturally occurring cannabinoids and have been reported to show improved efficacy or tolerability, attributed synergy between other components plant. Although 'synergy' indicates that two more active compounds may produce an additive combined effect greater than their individual analgesic effect, potentiation biological a compound by related but inactive compounds, combination, was termed 'entourage effect'. Here, we review current evidence potential synergistic entourage effects pain relief. However, definitive clinical trials vitro functional studies are still required.Lay abstract Cannabis-based medicines used millennia, identified main constituents relief, cannabidiol (CBD). contains hundreds potentially underlie preference some patients cannabinoid extracts, rather delta-9-tetrahydrocannabinol. Further, cannabis-based drugs interact with endocannabinoids, which produced within body found cannabis. We reviewed drugs, there is advantage combinations, basic research required.

Язык: Английский

---

Cannabinoids and Terpenes: How Production of Photo-Protectants Can Be Manipulated to Enhance Cannabis sativa L. Phytochemistry

Frontiers in Plant Science, Год журнала: 2021, Номер 12

Опубликована: Май 31, 2021

Cannabis sativa L. is cultivated for its secondary metabolites, of which the cannabinoids have documented health benefits and growing pharmaceutical potential. Recent legal cannabis production in North America Europe has been accompanied by an increase reported findings optimization naturally occurring synthetic cannabinoid production. Of many environmental cues that can be manipulated during plant growth controlled environments, cultivation with different lighting spectra indicates differential accumulation medically important cannabinoids, including Δ 9 -tetrahydrocannabinol (Δ -THC), cannabidiol (CBD), cannabigerol (CBG), as well terpenes flavonoids. Ultraviolet (UV) radiation shows potential stimulating biosynthesis trichomes pre-harvest or post-harvest UV treatment merits further exploration to determine if metabolite could enhanced this manner. Visible LED light augment THC terpene accumulation, but not CBD. Well-designed experiments wavelengths other than blue red will provide more insight into light-dependent regulatory molecular pathways cannabis. Lighting strategies such subcanopy varied at developmental stages lower energy consumption optimize PSM Although evidence demonstrates metabolites may modulated spectrum like species, several questions remain fast-paced industry. In summarizing recent research progress on cannabis, along pertinent responses model future directions are presented.

Язык: Английский

---

Cannabidiol (CBD) in Cancer Management

Cancers, Год журнала: 2022, Номер 14(4), С. 885 - 885

Опубликована: Фев. 10, 2022

The plant Cannabis sativa has been in use medicinally for several thousand years. It over 540 metabolites thought to be responsible its therapeutic effects. Two of the key phytocannabinoids are cannabidiol (CBD) and tetrahydrocannabinol (THC). Unlike THC, CBD does not have potentially intoxicating Preclinical clinical research indicates that a wide range effects, many them relevant management cancer. In this article, we explore some potential mechanisms action cancer, evidence efficacy integrative cancer including side effects associated with treatment, demonstrating integration orthodox care.

Язык: Английский

---

Cannabis Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial Pain

Molecules, Год журнала: 2022, Номер 28(1), С. 106 - 106

Опубликована: Дек. 23, 2022

The management of orofacial pain to alleviate the quality life affected patients is becoming increasingly challenging for scientific research and healthcare professionals. From this perspective, in addition conventional therapies, new alternatives are being sought, looking at use both natural synthetic products. Cannabis sativa L. represents an interesting source bioactive compounds, including non-psychoactive cannabinoids, flavonoids, terpenes, many which effective improving intensity. Here, we aim analyze possible mechanisms action hemp-derived compounds responsible modulatory effects on pain-related pathways. ability these act multiple through a synergistic effect, reducing release inflammatory mediators regulating response endocannabinoid system, makes them agents alternative formulations be used pain.

Язык: Английский

---

Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications

Biomedicines, Год журнала: 2023, Номер 11(10), С. 2630 - 2630

Опубликована: Сен. 25, 2023

Historically, cannabis has been valued for its pain-relieving, anti-inflammatory, and calming properties. Ancient civilizations like the Egyptians, Greeks, Chinese medicines recognized their therapeutic potential. The discovery of endocannabinoid system, which interacts with phytoconstituents, scientifically explained how affects human immune including central nervous system (CNS). This review explores evolving world cannabis-based treatments, spotlighting diverse applications. By researching current research clinical studies, we probe into cannabinoids Δ9-tetrahydrocannabinol (THC) cannabidiol (CBD) help to manage conditions ranging from chronic pain, persistent inflammation, cancer, inflammatory bowel disease, neurological disorders even viral diseases such as Human Immunodeficiency virus (HIV), SARS-CoV-2. emerging monkeypox. long-term recreational use can develop disorder (CUD), therefore, understanding factors contributing development maintenance addiction, genetic predisposition, neurobiological mechanisms, environmental influences, will be timely. Shedding light on adverse impacts CUD underscores importance early intervention, effective treatment approaches, public health initiatives address this complex issue in an landscape policies perceptions.

Язык: Английский

---

In vitro antioxidant, anti-inflammatory, and anticancer activities of mixture Thai medicinal plants

BMC Complementary Medicine and Therapies, Год журнала: 2023, Номер 23(1)

Опубликована: Фев. 10, 2023

The phytochemical study of medicinal plants is rapidly gaining popularity with many pharmacologic effects. This aims to determine the antioxidant capacity as well anticancer and antimigration activities Clear belongs Plus extract (CBL-P) which consisted five namely, Alpinia galanga, Piper nigrum, Citrus aurantifolia, Tiliacora triandra, Cannabis sativa on human colon cancer cells SW620 HCT116 cell lines, non-small lung A549 NCI-H460 lines.In this dried-plant powder was extracted using 90% ethanol. Additionally, CBL-P studied antioxidative activity via DPPH ABTS assays anti-inflammatory nitric oxide assay Griess reaction. Antiproliferation were investigated 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) scratch assay.The results showed that had potent antiproliferative IC50 values in a concentration- time-dependent manners for all four lines. also possessed against cells. demonstrated different types (A549, NCI-H460, HCT116, SW620) after 48 h incubation, greatest effect seen at highest concentration tested (15 μg/mL) (10.23% wound closure) (9.16% closure). effective reducing migration cells, range closure area from 10-50%. In addition, 8.549 ± 0.241 mg/mL 2.673 0.437 assays, respectively. best inhibitory NO production 40 μg/mL.In conclusion, mixture activity. Furthermore, plant significantly exhibited SW620, A549, (P ≤ 0.05). Taken together, our suggest may have synergistic effects could potentially enhance effectiveness treatment when used adjuvants. These findings provide solid scientific foundation future efforts explore mechanism action.

Язык: Английский

---

Using oils and fats to replace sugars as feedstocks for biomanufacturing: Challenges and opportunities for the yeast Yarrowia lipolytica

Biotechnology Advances, Год журнала: 2023, Номер 65, С. 108128 - 108128

Опубликована: Март 13, 2023

Язык: Английский

---

Nutraceutical potential, phytochemistry of hemp seed (Cannabis sativa L.) and its application in food and feed: A review

Food Chemistry Advances, Год журнала: 2024, Номер 4, С. 100671 - 100671

Опубликована: Март 23, 2024

Hemp seeds are gaining increasing attention in the realm of research due to their multifaceted nutritional and pharmaceutical properties. Notably, these offer a rich source protein, carbohydrates, polyunsaturated fatty acids, vitamins, minerals, making them valuable addition one's diet therefore, growing interest among researchers globally. A comprehensive literature review was conducted on prominent databases Scopus, Elsevier, PubMed using keywords "Hempseed," "Phytochemistry," "Nutraceuticals," food feed applications. Studies suggest that compounds exhibit therapeutic potential against conditions such as epilepsy, certain neurological disorders (Parkinson's Alzheimer's diseases), cardiovascular issues. Additionally, hemp possess other notable properties, anti-cancer, anti-inflammatory, immunomodulatory effects. They also used dietary supplement alleviate headaches, insomnia, high cholesterol levels, premenstrual syndrome symptoms women. Hempseed oil, powder, flour utilized enhance phenolic activity antioxidant properties products. hempseed cake, generated after cold pressing, boasts protein concentration, it for ruminants. However, further clinical trials necessary fully understand harness functional foods nutraceutical

Язык: Английский

---