Comparison of the cardiovascular system, clinical condition, and laboratory results in COVID-19 patients with and without vitamin D insufficiency

BMC Infectious Diseases, Год журнала: 2022, Номер 22(1)

Опубликована: Май 7, 2022

Serum vitamin D levels may have a protective role against severe coronavirus disease 2019 (COVID-19). Studies shown that deficiency in be significant risk factor for poor outcomes. This study aims to compare the outcome and clinical condition of patients diagnosed with COVID-19 infection considering serum levels.In this cross-sectional study, 202 without known cardiovascular (reduced ejection fraction, uncontrolled arrhythmia, pericardial effusion, cardiac block, valvular disease, or hypertension) were included. Patients divided into three groups insufficient (< 30 ng/mL), normal (30 50 high (> ng/mL) levels. Clinical was defined as if invasive respiratory intervention ICU admission required.The based on their level: 127 cases group, 53 22 group. The mean age population 56 years. Thirty-four had distribution group follows: 21 (16.5%), eight (15.1%), five (22.7%); P = 0.74. No differences found between terms mortality rate (P 0.46). Moreover, leukocytes (mean ± SD 6873.5 4236.2), ESR 38.42 26.7), CPK-MB 63 140.7) higher but it not statistically > 0.05).The finding present showed could make difference systems, laboratory results, severity patients.

Язык: Английский

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The role of vitamin D in prevention OF COVID-19 and its severity: an umbrella review.

PubMed, Год журнала: 2021, Номер 92(S6), С. e2021451 - e2021451

Опубликована: Окт. 1, 2021

Vitamin D is known to modulate immune response and its deficiency was associated with respiratory distress in patients hospitalized for pneumonia. Nevertheless, numerous reviews on vitamin COVID-19 have shown conflicting results, as previously reported also other diseases (e.g., influenza).This umbrella review aims assess whether low serum 25-OHD susceptibility COVID 19, their severity, mortality. A total of 1559 studies were excluded after the title, abstract full-text articles screening 9 papers included this review: 2 systematic 7 metanalysis.The findings that summarized from 5 WHO regions (European Region, Region Americas, South-East Asia Eastern Mediterranean Western Pacific Region) exclusion only African region, show levels are higher infection risks COVID-19.Although indicate a potential role severity showing an association between supplementation however, more robust data randomized controlled trials further needed confirm possible mortality rates.

Язык: Английский

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Impact of Vitamin D Therapy on C-Reactive Protein, Ferritin, and IL-6 Levels in Hospitalised Covid-19 Patients

Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences, Год журнала: 2023, Номер 77(3-4), С. 153 - 161

Опубликована: Авг. 1, 2023

Abstract Vitamin D insufficiency is associated with poor prognosis in COVID-19 patients. supplementation related to improved clinical outcomes terms of intensive care unit admission and death, particularly individuals moderate-to-severe forms COVID-19. The placebo-controlled five-day study was performed on 99 hospitalised patients vitamin randomised into two groups. the form a sublingual sprayable microemulsion given three times daily (daily dose 12,000 IU) 51 blood 25(OH)D levels below 30 ng/ml. Forty-eight control group received placebo spray same regimen. Intention-to-treat (ITT) analysis pre-protocol were used verify impact level elevation inflammatory markers. There statistically significant increase by 8.7 ± 7.6 ng/ml from baseline 15.6 6.5 case group. Individuals moderately severe disease showed negative correlation between changes C-reactive protein (CRP) both ITT ( p < 0.05). Mild cases no statistical significance CRP levels. ferritin IL-6 analysis. In conclusion, high-dose therapy accompanied decrease moderate illness.

Язык: Английский

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Vitamins for the Prevention and/or Treatment of COVID-19: An Umbrella Review

CAND Journal, Год журнала: 2023, Номер 30(4), С. 15 - 31

Опубликована: Дек. 28, 2023

Objective: This umbrella review synthesizes the existing literature on role of vitamins for COVID-19 prevention and management. The objective is to elucidate potential preventive therapeutic dimensions these vitamins, highlight clinical applicability, identify avenues future research. Methods: A systematic search was conducted using PubMed Google Scholar, with predefined key words each vitamin combined COVID-19-related terms. Narrative reviews were included, following Cochrane guidelines. AMSTAR scoring used assess quality, while SANRA guidelines evaluate narrative reviews. Data extraction, synthesis, reference overlap conducted. Findings: (n=14) revealed preclinical benefits A, B group, C, D, E (no research K found) in management, immune modulation anti-inflammatory responses. Of (n=44), none included or E. Some exhibited potential, significant associations between C supplementation reduced severity. Many findings also found D deficiency heightened risks, as well promising effects supplementation. Conclusion: Vitamins hold mechanistic rationale combating COVID-19, suggested by In reviews, underscores its severity, show adjunct therapies. highlights comprehensive efficacy addressing challenges that warrant further investigation.

Язык: Английский

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COMPARAÇÃO DE TRATAMENTOS MEDICAMENTOSOS EM PACIENTES INTERNADOS COM COVID19

Brazilian Journal of Implantology and Health Sciences, Год журнала: 2024, Номер 6(1), С. 212 - 227

Опубликована: Янв. 5, 2024

Esta revisão sistemática tem por objetivo comparar os medicamentos utilizados para tratamento da covid19 em pacientes diagnosticados com a doença e internados. A busca nas bases dados gerou 97 referências, que após o processo de seleção elegibilidade, foram selecionadas 4 revisões sistemáticas (RS) utilizadas nesta síntese narrativa onde seus extraídos. ferramenta AMSTAR 2 foi utilizada na avaliação qualidade metodológica. As opções agrupadas acordo as intervenções adotadas: Tociluzumabe, vitamina D Atorvastatina. Conclui-se estudo possui limitações sua metodologia, devendo resultados serem analisados prudência. apresentadas necessitam descrever padrão utilizado. O tociluzumabe se mostra melhor escolha uso concomitante padrão.

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