Annales de Dermatologie et de Vénéréologie - FMC, Год журнала: 2024, Номер 4(8), С. 8S27 - 8S35
Опубликована: Ноя. 27, 2024
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Фев. 10, 2025
Atopic dermatitis and psoriasis have traditionally been considered distinct inflammatory skin diseases with unique pathogenic mechanisms. However, accumulating evidence suggests significant overlap in their immunological pathways, metabolic features, microbiome characteristics, challenging this conventional dichotomy. This review comprehensively examines the complex relationship between atopic dermatitis, particular emphasis on shared We analyze networks, microbial factors contributing to development progression. The expands upon disease spectrum hypothesis discusses nomenclature for conditions exhibiting features of both diseases. critically evaluate clinical histopathological characteristics concomitant highlighting recent advances molecular diagnostics accurate differentiation. Importantly, we propose standardized diagnostic criteria examine current therapeutic strategies managing overlapping conditions. Recent developments targeted therapies implications treatment selection are thoroughly discussed. By synthesizing identifying knowledge gaps, provides insights into interplay aiming guide decision-making future research directions evolving field.
Язык: Английский
Процитировано
0
Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)
Опубликована: Фев. 12, 2025
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Март 19, 2025
Psoriasis and atopic dermatitis are among the most frequent chronic, inflammatory skin diseases of childhood adolescence. Regarding profound consequences for physical psychosocial development affected patients, a timely individually adapted therapy has to be initiated, in case severe disease systemic treatment. Modern, targeted, highly efficient well-tolerated agents currently available. Overlapping psoriasis have been appreciated recently, both idiopathic therapeutically induced. Their prevention or early detection is mandatory optimal management patients.
Язык: Английский
Процитировано
0
Russian Journal of Clinical Dermatology and Venereology, Год журнала: 2025, Номер 24(2), С. 178 - 178
Опубликована: Апрель 25, 2025
Currently, pathogenesis of atopic dermatitis (AD) and psoriasis is being reviewed due to the fact that a concept possibility switching inflammatory reaction with different profiles pro-inflammatory cytokines depending on body condition (age, pregnancy) received treatment (GEBT) has been formed. Objective. To study nucleotide sequence variants (NSVs) in filaggrin (FLG), interleukin 4 (IL4) tumor necrosis factor α (TNFA) genes patients AD. The results NSVs testing cells obtained by scraping skin epithelium inner surface cheek were analyzed. A total 5 groups (419 patients) formed: control group (n=78) diseases association dry skin. Results. Pathogenic FLG gene have encountered among occurring addition xerosis approximately same frequency as healthy people who applied for preventive examination (7.4% 5.1%, respectively). No significant differences incidence pathogenic found AD severity presence well: 26.6% mild moderate disease 27.2% severe had NSVs. minor «T» allele IL4 21/2% individuals 31.8% In addition, more likely (22/7%) «A» TNFA gene, which 10.3% group, least often (7.4%) psoriasis. Conclusion. allow recommend performance genetic identification carry out determination alleles genes, respectively, if 2282del4 pathological NSV detected.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9192 - 9192
Опубликована: Авг. 24, 2024
(1): Atopic dermatitis and psoriasis vulgaris are chronic, inflammatory diseases. Clinical presentation usually leads to a proper diagnosis, but sometimes neither clinical examination nor histopathological evaluation can be conclusive. Therefore, we aimed build up novel diagnostic tool check it for accuracy. The main objective of our work was differentiate between healthy skin (C), atopic (AD) (PV) biopsies on the base involucrin (IVL) human β-defensin-2 (hBD-2) concentrations their mRNA, as well mRNA TPP2 PSMB8. (2): ELISA IVL hBD-2 proteins Real-time PCR relative expression for: (IVL mRNA), (hBD-2 PSMB8 (PSMB8 mRNA) (TPP2 isolated from taken AD PV patients volunteers were performed. (3): correlated with some parameters assessment disease severity. expression, exclusively, sufficient distinguish ones. (4): analysis most valuable in differentiating biopsies.
Язык: Английский
Процитировано
1
International Journal of Dermatology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 2, 2024
Abstract Dermatology has seen significant advancements in understanding and treating complex immune‐mediated chronic inflammatory skin conditions such as psoriasis atopic dermatitis. This editorial highlights five pivotal studies that delve into the real‐world effectiveness of biological therapies challenges pediatric patients with overlapping dermatological conditions. These collectively underscore need for continued research treatment approaches dermatology.
Язык: Английский
Процитировано
0
International Journal of Dermatology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 21, 2024
Язык: Английский
Процитировано
0
Annales de Dermatologie et de Vénéréologie - FMC, Год журнала: 2024, Номер 4(8), С. 8S27 - 8S35
Опубликована: Ноя. 27, 2024
Процитировано
0