Emerging trends and research foci in gastrointestinal microbiome

Journal of Translational Medicine, Год журнала: 2019, Номер 17(1)

Опубликована: Фев. 28, 2019

Gastrointestinal microbiome has drawn an increasing amount of attention over the past decades. There is emerging evidence that gut flora plays a major role in pathogenesis certain diseases. We aimed to analyze evolution gastrointestinal research and evaluate publications qualitatively quantitatively.We obtained record 2891 manuscripts published between 1998 2018 from Web Science Core Collection (WoSCC) Thomson Reuters; this was on June 23, 2018. The WoSCC most frequently used source scientific information. term "Gastrointestinal Microbiomes" all its hyponyms retrieve record, restricted subjects gastroenterology hepatology. then derived clustered network 70,169 references were cited by manuscripts, identified 676 top co-cited articles. Next, we bibliometric method, CiteSpace V, VOSviewer 1.6.8 identify authors, journals, institutions, countries, keywords, articles, trends.We number time. 112 journals articles microbiome. United States America leading country for publications, institution University North Carolina. Co-cited reference analysis revealed landmark field. Gut microbiota, inflammatory bowel disease (IBD), probiotics, irritable disease, obesity are some high frequency keywords co-occurrence cluster analysis; indicating microbiota related digestive diseases remain hotspots research. Burst detection showed bile acid, obesity, Akkermansia muciniphila new foci.This study our understanding link associated evolved dramatically therapeutic targets would be foci future

Язык: Английский

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T follicular helper cells and T follicular regulatory cells in rheumatic diseases

Nature Reviews Rheumatology, Год журнала: 2019, Номер 15(8), С. 475 - 490

Опубликована: Июль 9, 2019

Язык: Английский

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Mitochondria: It is all about energy

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Апрель 25, 2023

Mitochondria play a key role in both health and disease. Their function is not limited to energy production but serves multiple mechanisms varying from iron calcium homeostasis the of hormones neurotransmitters, such as melatonin. They enable influence communication at all physical levels through interaction with other organelles, nucleus, outside environment. The literature suggests crosstalk between mitochondria circadian clocks, gut microbiota, immune system. might even be hub supporting integrating activity across these domains. Hence, they (missing) link Mitochondrial dysfunction related metabolic syndrome, neuronal diseases, cancer, cardiovascular infectious inflammatory disorders. In this regard, diseases Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS), chronic fatigue syndrome (CFS), pain are discussed. This review focuses on understanding mitochondrial action that allow for maintenance pathways toward dysregulated mechanisms. Although have allowed us adapt changes over course evolution, turn, evolution has shaped mitochondria. Each evolution-based intervention influences its own way. use physiological stress triggers tolerance stressor, achieving adaptability resistance. describes strategies could recover functioning providing comprehensive, root-cause-focused, integrative approach recovering treating people suffering diseases.

Язык: Английский

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Modulatory effects of polysaccharides from plants, marine algae and edible mushrooms on gut microbiota and related health benefits: A review

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 204, С. 169 - 192

Опубликована: Фев. 2, 2022

Язык: Английский

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Efficacy and safety of gut microbiota-based therapies in autoimmune and rheumatic diseases: a systematic review and meta-analysis of 80 randomized controlled trials

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Март 13, 2024

Abstract Background Previous randomized controlled trials (RCTs) suggested that gut microbiota-based therapies may be effective in treating autoimmune diseases, but a systematic summary is lacking. Methods Pubmed, EMbase, Sinomed, and other databases were searched for RCTs related to the treatment of diseases with probiotics from inception June 2022. RevMan 5.4 software was used meta-analysis after 2 investigators independently screened literature, extracted data, assessed risk bias included studies. Results A total 80 14 types disease [celiac sprue, SLE, lupus nephritis (LN), RA, juvenile idiopathic arthritis (JIA), spondyloarthritis, psoriasis, fibromyalgia syndrome, MS, systemic sclerosis, type 1 diabetes mellitus (T1DM), oral lichen planus (OLP), Crohn’s disease, ulcerative colitis] included. The results showed improve symptoms and/or inflammatory factor celiac SLE LN, JIA, PSS, colitis. However, not spondyloarthritis RA. Gut relieve pain effect on impact questionnaire score significant. HbA1c T1DM, its insulin requirement does seem These did increase incidence adverse events. Conclusions several (celiac colitis).

Язык: Английский

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Role of Probiotics against Human Cancers, Inflammatory Diseases, and Other Complex Malignancies

Journal of Food Biochemistry, Год журнала: 2024, Номер 2024, С. 1 - 23

Опубликована: Фев. 7, 2024

Probiotics have growing medical importance as a result of their potential in the prevention and therapeutic support several complex diseases, including different types cancers. The anticarcinogenic properties probiotics are attributed to various mechanisms, alterations composition intestinal microbiota, suppression cell proliferation, stimulation apoptosis, inhibition NF-kB, reduction levels H2AX, 8-hydroxy-deoxyguanosine, RIG-I, downregulation IL-17, TNF signaling pathway. Furthermore, demonstrated significant advantages management other diabetes, obesity, cardiovascular diseases. had considerable effect reducing inflammatory infiltration occurrence precancerous lesions. Additionally, administration led decrease appearance level genes related proinflammatory pathways, NF-κB, pathways. However, further research studies required comprehend processes via which exert effects authenticate alternative interventions.

Язык: Английский

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Probiotics in Autoimmune and Inflammatory Disorders

Nutrients, Год журнала: 2018, Номер 10(10), С. 1537 - 1537

Опубликована: Окт. 18, 2018

Probiotics have been used to ameliorate gastrointestinal symptoms since ancient times. Over the past 40 years, probiotics shown impact immune system, both in vivo and vitro. This interaction is linked gut microbes, their polysaccharide antigens, key metabolites produced by these bacteria. At least four metabolic pathways implicated mechanistic studies of probiotics, based on animal models. Microbial⁻immune system crosstalk has to: short-chain fatty acid production signaling, tryptophan metabolism activation aryl hydrocarbon receptors, nucleoside signaling gut, intestinal histamine-2 receptor. Several randomized controlled trials now that microbial modification may improve multiorgan inflammation rheumatoid arthritis, ulcerative colitis, multiple sclerosis. Future work will need carefully assess safety issues, selection optimal strains combinations, attempts prolong duration colonization beneficial microbes.

Язык: Английский

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Host–microbiota interactions in rheumatoid arthritis

Experimental & Molecular Medicine, Год журнала: 2019, Номер 51(12), С. 1 - 6

Опубликована: Дек. 1, 2019

Abstract The gut microbiota has been proposed to be an important environmental factor in the development of rheumatoid arthritis (RA). Here, we review a growing body evidence from human and animal studies that supports hypothesis intestinal play role RA. Previous others showed altered composition early RA patients. A recent study demonstrated Prevotella species are dominant intestine patients preclinical stages In addition, -dominated isolated contributes Th17 cell-dependent SKG mice. Moreover, it was reported periodontal bacteria correlates with pathogenesis this review, discuss link between oral arthritis. However, many questions remain elucidated terms molecular mechanisms for involvement pathogenesis.

Язык: Английский

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Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives

Mediators of Inflammation, Год журнала: 2018, Номер 2018, С. 1 - 17

Опубликована: Янв. 1, 2018

The gut environment and microbiome dysbiosis have been demonstrated to significantly influence a range of disorders in humans, including obesity, diabetes, rheumatoid arthritis, multiple sclerosis (MS). MS is an autoimmune disease affecting the central nervous system (CNS). etiology not clear, it should involve both genetic extrinsic factors. factors responsible for predisposition remain elusive. Recent studies on its animal model, experimental encephalomyelitis (EAE), found that gastrointestinal microbiota may play important role pathogenesis MS/EAE. Thus, adjustment be future direction treatment MS. In this review, we discuss characteristics microbiota, connection between brain gut, changes MS/EAE, explore possibility applying therapies patients with

Язык: Английский

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Environmental Exposures and Autoimmune Diseases: Contribution of Gut Microbiome

Frontiers in Immunology, Год журнала: 2020, Номер 10

Опубликована: Янв. 10, 2020

Environmental agents have gained much attention in recent years for their role triggering autoimmune diseases (ADs). Increasing evidence has linked environmental exposures, including trichloroethene (TCE), silica, mercury, pristane, pesticides and smoking to higher risk ADs. However, potential mechanisms by which these contribute the disease pathogenesis remains largely unknown. Dysbiosis of gut microbiome is another important factor that been onset different Altered microbiota composition associated with impaired intestinal barrier function dysregulation mucosal immune system, but it unclear if dysbiosis a causal or an outcome In this review article, we first describe epidemiological mechanistic evidences linking environmental/occupational exposures various ADs (especially SLE). Secondly, discuss how changes (dysbiosis) could pathogenesis, especially response exposure chemicals.

Язык: Английский

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