Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 1 - 32
Опубликована: Авг. 28, 2024
The
immune
system
plays
a
major
role
leading
to
extraordinary
immunotherapeutic
interventions.
Immune
checkpoint
blockade
has
emerged
as
revolutionary
development
in
cancer
therapeutics.
Adoptive
cell
therapy
(ACT)
come
out
promising
avenue,
involving
the
infusion
of
tumor-infiltrating
lymphocytes
(TIL)
or
genetically
engineered
T
cells
showing
innovative
receptors
(TCR)
chimeric
antigen
(CAR).
These
interventions
encourage
utilize
capacity
target
tumor
successfully.
Supportive
outcomes
have
been
recorded
across
various
types,
resulting
advancement
global
clinical
trials
refine
and
improvise
ACT
protocols.
Significantly
favorable
results
seen
hematological
malignancies
well
impressive
case
against
solid
tumors
become
an
important
milestone
for
researchers.
This
chapter
discusses
different
types
advancements
ACT,
describes
associated
toxicities,
predicts
its
future
potential
therapeutics
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(16), С. 12630 - 12630
Опубликована: Авг. 10, 2023
Liver
cancer
is
one
of
the
most
lethal
malignant
cancers
worldwide.
However,
therapeutic
options
for
advanced
liver
are
limited
and
reveal
scant
efficacy.
The
current
study
investigated
effects
nivolumab
(Niv)
escitalopram
oxalate
(Esc)
in
combination
on
proliferation
cells
both
vitro
vivo.
Significantly
decreased
viability
HepG2
that
were
treated
with
Esc
or
Niv
was
observed
a
dose-dependent
manner
at
24
h,
48
72
h.
Administration
(50
μM)
+
(20
μM),
(75
(5
over
h
exhibited
synergistic
effects,
inhibiting
survival
cells.
Additionally,
treatment
(1
Finally,
survival.
Com-pared
controls,
significantly
increased
sub-G1
portion
annexin-V
signals.
In
xenograft
animal
study,
(6.66
mg/kg)
(2.5
suppressed
growth
tumors
nude
mice.
This
reports
first
time
combined
administration
cell
proliferation,
which
may
provide
an
alternative
option
treatment.
Most
cancers
have
a
downregulation
of
Fidgetin
(FIGN),
which
has
been
linked
to
tumor
growth.
However,
there
arenât
many
papers
that
mention
FIGNâs
connection
hepatocellular
carcinoma
(HCC).
Here,
FIGN
expression
in
HCC
tissues
was
markedly
reduced
as
compared
nearby
normal
liver
tissues.
According
univariate
and
multivariate
Cox
regression,
it
served
an
independent
predictor
survival
outcomes.
Patients
with
high
levels
had
worse
outcome.
shown
be
engaged
immune-related
pathways
positive
correlation
immunological
score
immune
cells
according
KEGG
pathway
analysis.
In
patients,
substantially
checkpoints
the
hot
state.
Additionally,
immunotherapy
chemotherapy
showed
significant
therapeutic
response
patients
low
expression.
This
research
revealed
tightly
related
hepatoma
immunity
might
employed
biomarker
predict
patient
prognosis
guide
medication.
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 12, 2024
Hepatocellular
carcinoma
(HCC)
is
a
major
global
health
concern,
and
understanding
the
complex
interplay
of
immune
cells
within
tumor
microenvironment
crucial.
This
review
explores
roles
myeloid-derived
suppressor
(MDSCs)
macrophages
in
HCC,
focusing
on
their
molecular
pathways,
immunometabolic
processes,
implications
for
immunotherapy.
We
begin
by
elucidating
origin,
expansion,
immunosuppressive
mechanisms
MDSCs,
emphasizing
importance
pathways
immunometabolism
regulating
functions.
In
parallel,
we
delve
into
dual
nature
tumor-associated
(TAMs)
discuss
metabolic
cues
governing
plasticity.
Tumor
metabolism
central
theme,
with
comprehensive
overview
altered
processes
cancer
impact
microenvironment.
examine
crosstalk
between
cells,
macrophages,
shedding
light
how
contributes
to
evasion.
Furthermore,
challenges
limitations
faced
clinical
application
immunotherapy
HCC.
conclusion,
this
highlights
intricate
web
shaping
functions
MDSCs
Understanding
these
dynamics
essential
innovative
immunotherapeutic
interventions
improving
outcomes
devastating
disease.
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Июль 11, 2024
Background
This
study
aims
to
screen
inflammation-related
genes
closely
associated
with
the
prognosis
of
hepatocellular
carcinoma
(HCC)
accurately
forecast
HCC
patients.
Methods
Gene
expression
matrices
and
clinical
information
for
liver
cancer
samples
were
obtained
from
Cancer
Genome
Atlas
(TCGA)
International
Consortium
(ICGC).
An
intersection
differentially
expressed
normal
GeneCards
yielded
HCC.
Cox
regression
minor
absolute
shrinkage
selection
operator
(LASSO)
analysis
filter
prognosis.
The
prognostic
value
model
was
confirmed
by
drawing
Kaplan–Meier
ROC
curves.
Select
between
high-risk
low-risk
groups
perform
GO
KEGG
pathways
analyses.
CIBERSORT
conducted
assess
associations
risk
models
immune
cells
verified
using
real-time
qPCR.
Results
A
total
six
hub
(C3,
CTNNB1,
CYBC1,
DNASE1L3,
IRAK1,
SERPINE1)
selected
multivariate
construct
a
model.
validation
evaluation
showed
that
it
has
an
excellent
ability
predict
line
plot
drawn
indicate
patients’
survival,
calibration
curve
revealed
satisfactory
predictability.
Among
genes,
C3
DNASE1L3
are
relatively
low
in
HCCLM3
97H
cell
lines,
while
SERPINE1
overexpressed
lines.
Conclusion
One
new
inflammatory
factor-associated
constructed
this
study.
score
can
be
independent
predictor
judging
survival.
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 1 - 32
Опубликована: Авг. 28, 2024
The
immune
system
plays
a
major
role
leading
to
extraordinary
immunotherapeutic
interventions.
Immune
checkpoint
blockade
has
emerged
as
revolutionary
development
in
cancer
therapeutics.
Adoptive
cell
therapy
(ACT)
come
out
promising
avenue,
involving
the
infusion
of
tumor-infiltrating
lymphocytes
(TIL)
or
genetically
engineered
T
cells
showing
innovative
receptors
(TCR)
chimeric
antigen
(CAR).
These
interventions
encourage
utilize
capacity
target
tumor
successfully.
Supportive
outcomes
have
been
recorded
across
various
types,
resulting
advancement
global
clinical
trials
refine
and
improvise
ACT
protocols.
Significantly
favorable
results
seen
hematological
malignancies
well
impressive
case
against
solid
tumors
become
an
important
milestone
for
researchers.
This
chapter
discusses
different
types
advancements
ACT,
describes
associated
toxicities,
predicts
its
future
potential
therapeutics
