Cracking Lysine Crotonylation (Kcr): Enlightening a Promising Post‐Translational Modification DOI Creative Commons

Marinda Westerveld,

Kosta Besermenji,

David Aidukas

и другие.

ChemBioChem, Год журнала: 2024, Номер unknown

Опубликована: Окт. 27, 2024

Abstract Lysine crotonylation (Kcr) is a recently discovered post‐translational modification (PTM). Both histone and non‐histone Kcr‐proteins have been associated with numerous diseases including cancer, acute kidney injury, HIV latency, cardiovascular disease. Histone Kcr enhances gene expression to larger extend than the extensively studied lysine acetylation (Kac), suggesting as novel potential therapeutic target. Although scientific reports on were published in last years, relevant knowledge gaps concerning this PTM its regulation still remain. To date, only few selective Kcr‐interacting proteins identified methods for enrichment of chemical proteomics analysis are lacking. The development new techniques study underexplored could then clarify function health disease hopefully accelerate therapeutics Kcr‐related Herein we briefly review what known about mechanisms current used identify their interacting partners. This report aims highlight significant target existing that research must address.

Язык: Английский

Lactylation: The Metabolic Accomplice Shaping Cancer's Response to Radiotherapy and Immunotherapy DOI
Danqing Yu, Qingping Zhong, Yanlin Wang

и другие.

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102670 - 102670

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Updating on the Dual Role of Salivary Gland Epithelial Cell (SGEC) in Sjögren’s Disease DOI Creative Commons

Wen Zhu,

Yun Lu,

Yifan Zhu

и другие.

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 3039 - 3053

Опубликована: Фев. 28, 2025

Sjögren's disease, an autoimmune inflammatory currently lacks effective treatment options. The salivary gland, a crucial exocrine organ responsible for saliva production and local immune responses on mucous membranes, is frequently impaired in individuals with disease. Restoring gland function poses significant challenge researchers. Salivary epithelial cells, recognized as pivotal components of the have been increasingly implicated key initiators inflammation exhibit innate cell-like properties. On whole, SGEC plays protective role physiological state, can also participate persistence initiating factor pathological state. In review, we explore interplay between Ca+, endoplasmic reticulum (ER), mitochondrial homeostasis imbalance cells. Additionally, provide overview current literature research advancements related to Pattern Recognition Receptors (PRRs), programmed cell death, posttranslational modification (PTM), oral microecology, etc. specifically focusing their implications Given cells onset based may potential alleviate condition by addressing response glands.

Язык: Английский

Процитировано

0
Proteomic Analysis and 2-Hydroxyisobutyrylation Profiling in Metabolic Syndrome Induced Restenosis DOI Creative Commons
Xiangyu Liu, Liping Zhou,

Wen‐Jing Huang

и другие.

Molecular & Cellular Proteomics, Год журнала: 2025, Номер unknown, С. 100978 - 100978

Опубликована: Апрель 1, 2025

Restenosis is the primary complication following stenting for coronary and peripheral arterial disease (PAD), posing an ongoing clinical challenge. Metabolic syndrome (MetS), characterized by metabolic disturbances, has been identified as independent predictor postoperative restenosis in carotid arteries, potentially due to endothelial dysfunction augmented oxidative stress cells, while its specific regulatory mechanism still largely unknown. Lysine 2-hydroxyisobutyrylation (Khib), a recently post-translational modification, plays crucial role transcriptional regulation cellular metabolism. However, there lack of comprehensive analysis proteome Khib modifications within restenotic vessels context MetS, well understanding associated pathophysiology. In this study, we observed significant upregulation arteries induced confirmed animal experiments. Further, using high-throughput liquid chromatography-mass spectrometry, catalogued 15,558 sites across 2,568 proteins, implicating multitude biological functions. Analysis revealed 2,007 on 1,002 proteins with considerable differential which are present cytoplasm nucleus. Interestingly, located mitochondria, endoplasmic reticulum, cell membrane also exhibit distinct expression modification profiles varying extents that related vascular smooth muscle contraction, platelet activation, PI3K-Akt signaling pathway. Notably, level COL1A1 protein detected PPI pathway network diametrically opposed, suggesting disease's pathogenesis. This study provides first proteomic overview MetS-related in-stent vasculature, offering key insights inform novel therapeutic approaches mitigation.

Язык: Английский

Процитировано

0
Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies DOI Creative Commons
Xi Chen,

Yixiao Yuan,

Fan Zhou

и другие.

MedComm, Год журнала: 2025, Номер 6(6)

Опубликована: Май 29, 2025

ABSTRACT Lactylation, a recently identified post‐translational modification, represents groundbreaking addition to the epigenetic landscape, revealing its pivotal role in gene regulation and metabolic adaptation. Unlike traditional modifications, lactylation directly links intermediates, such as lactate, protein function cellular behavior. Emerging evidence highlights critical involvement of diverse biological processes, including immune response modulation, differentiation, tumor progression. However, regulatory mechanisms, implications, disease associations remain poorly understood. This review systematically explores enzymatic nonenzymatic mechanisms underlying lactylation, shedding light on interplay between metabolism control. We comprehensively analyze functions normal physiology, homeostasis tissue repair, dysregulation pathological contexts, cancer, inflammation, disorders. Moreover, we discuss advanced detection technologies potential therapeutic interventions targeting pathways. By integrating these insights, this aims bridge knowledge gaps propose future directions for research. Highlighting lactylation's multifaceted roles health disease, provides timely resource understanding clinical particularly novel target precision medicine oncological therapies.

Язык: Английский

Процитировано

0
Cracking Lysine Crotonylation (Kcr): Enlightening a Promising Post‐Translational Modification DOI Creative Commons

Marinda Westerveld,

Kosta Besermenji,

David Aidukas

и другие.

ChemBioChem, Год журнала: 2024, Номер unknown

Опубликована: Окт. 27, 2024

Abstract Lysine crotonylation (Kcr) is a recently discovered post‐translational modification (PTM). Both histone and non‐histone Kcr‐proteins have been associated with numerous diseases including cancer, acute kidney injury, HIV latency, cardiovascular disease. Histone Kcr enhances gene expression to larger extend than the extensively studied lysine acetylation (Kac), suggesting as novel potential therapeutic target. Although scientific reports on were published in last years, relevant knowledge gaps concerning this PTM its regulation still remain. To date, only few selective Kcr‐interacting proteins identified methods for enrichment of chemical proteomics analysis are lacking. The development new techniques study underexplored could then clarify function health disease hopefully accelerate therapeutics Kcr‐related Herein we briefly review what known about mechanisms current used identify their interacting partners. This report aims highlight significant target existing that research must address.

Язык: Английский

Процитировано

0