Necroptosis in Immuno-Oncology and Cancer Immunotherapy DOI Creative Commons
Jenny Sprooten, Pieter De Wijngaert, Isaure Vanmeerbeek

и другие.

Cells, Год журнала: 2020, Номер 9(8), С. 1823 - 1823

Опубликована: Авг. 1, 2020

Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the subfield of immuno-oncology. Despite this renaissance, a subset cancer patients remain unresponsive to ICBs due widespread immuno-resistance. To “break” cell-driven immuno-resistance, researchers long floated idea therapeutically facilitating immunogenicity cells by disrupting tumor-associated immuno-tolerance via conventional anticancer therapies. It is well appreciated that therapies causing immunogenic or inflammatory cell death are best positioned productively activate immunity. A large proportion studies emphasized importance apoptosis (i.e., ICD); yet, it has also emerged necroptosis, programmed necrotic pathway, can be immunogenic. Emergence proficient immune profile for necroptosis important implications because resistance one major hallmarks tumors. Putative characteristics driven great impact in However, as typical highly complex multi-factorial disease like cancer, clear cause versus consensus relationship on immunobiology been tough establish. In review, we discuss various aspects with specific focus immuno-oncology immunotherapy.

Язык: Английский

Ferroptosis, a new form of cell death: opportunities and challenges in cancer DOI Creative Commons

Yanhua Mou,

Jun Wang, Jinchun Wu

и другие.

Journal of Hematology & Oncology, Год журнала: 2019, Номер 12(1)

Опубликована: Март 29, 2019

Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies ferroptosis cancer have boosted perspective for its usage therapeutics. Here, we review the current findings regulation especially focus on function ncRNAs mediating process ferroptotic how was relation to other regulated deaths. Aberrant diverse types tissues were summarized, elaborated recent data about actors some "conventional" drugs natural compounds as inducers cancer. Finally, deliberate future orientation cells unsettled issues, which may forward speed clinical use induction treatment.

Язык: Английский

Процитировано

1484
Therapeutic cancer vaccines DOI
Mansi Saxena, Sjoerd H. van der Burg, Cornelis J.M. Melief

и другие.

Nature reviews. Cancer, Год журнала: 2021, Номер 21(6), С. 360 - 378

Опубликована: Апрель 27, 2021

Язык: Английский

Процитировано

1135
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? DOI Creative Commons
Carlos Rosales

Frontiers in Physiology, Год журнала: 2018, Номер 9

Опубликована: Фев. 19, 2018

Neutrophils are the most abundant leukocytes in circulation, and have been regarded as first line of defense innate arm immune system. They capture destroy invading microorganisms, through phagocytosis intracellular degradation, release granules, formation neutrophil extracellular traps after detecting pathogens. also participate mediators inflammation. The classical view for these is that neutrophils constitute a homogenous population terminally differentiated cells with unique function. However, evidence accumulated recent years, has revealed present large phenotypic heterogeneity functional versatility, which place important modulators both inflammation responses. Indeed, roles played by homeostatic conditions well pathological processes focus renovated interest biology. In this review, I concept describe several subpopulations reported to date. discuss role seem play homeostasis disease.

Язык: Английский

Процитировано

1107
Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors DOI
Lorenzo Galluzzi, Juliette Humeau,

Aitziber Buqué

и другие.

Nature Reviews Clinical Oncology, Год журнала: 2020, Номер 17(12), С. 725 - 741

Опубликована: Авг. 5, 2020

Язык: Английский

Процитировано

1035
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death DOI Creative Commons
Lorenzo Galluzzi, Ilio Vitale, Sarah H. Warren

и другие.

Journal for ImmunoTherapy of Cancer, Год журнала: 2020, Номер 8(1), С. e000337 - e000337

Опубликована: Март 1, 2020

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular microenvironmental features determine the propensity of RCD drive immunity. Here, we provide updated operational definition immunogenic (ICD), discuss key factors that dictate ability dying cells response, summarize experimental assays are currently available for assessment ICD in vitro vivo, formulate guidelines their interpretation.

Язык: Английский

Процитировано

871
Endoplasmic reticulum stress signalling – from basic mechanisms to clinical applications DOI Creative Commons

Aitor Almanza,

Antonio Carlesso, Chetan Chintha

и другие.

FEBS Journal, Год журнала: 2018, Номер 286(2), С. 241 - 278

Опубликована: Июль 20, 2018

The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of secretory pathway. As such, ER contributes to production folding approximately one-third cellular proteins, thus inextricably linked maintenance homeostasis fine balance between health disease. Specific stress signalling pathways, collectively known as unfolded protein response (UPR), are required for maintaining homeostasis. UPR triggered when capacity overwhelmed by demand initially aims restore normal functions. However, if this fails, then triggers cell death. In review, we provide signalling-centric view functions, from ER's discovery latest advancements in understanding biology. Our review provides synthesis revolving around proteostasis UPR, its impact on other organelles behaviour, multifaceted dynamic role physiology, before finally exploring potential exploitation knowledge tackle unresolved biological questions address unmet biomedical needs. Thus, an integrated global existing literature pathways their use therapeutic purposes.

Язык: Английский

Процитировано

826
Antibody–drug conjugates for cancer DOI
Cindy H. Chau, Patricia S. Steeg, William D. Figg

и другие.

The Lancet, Год журнала: 2019, Номер 394(10200), С. 793 - 804

Опубликована: Авг. 1, 2019

Язык: Английский

Процитировано

637
Apoptosis and necroptosis in the liver: a matter of life and death DOI
Robert F. Schwabe, Tom Luedde

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2018, Номер 15(12), С. 738 - 752

Опубликована: Сен. 24, 2018

Язык: Английский

Процитировано

476
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages DOI Creative Commons
Els Wauters, Pierre Van Mol, Abhishek D. Garg

и другие.

Cell Research, Год журнала: 2021, Номер 31(3), С. 272 - 290

Опубликована: Янв. 21, 2021

Abstract How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune profiling of bronchoalveolar lavage (BAL) samples from 5 patients with mild 26 critical in comparison BALs non-COVID-19 pneumonia normal lung. We use pseudotime inference build T-cell monocyte-to-macrophage trajectories model gene expression changes along them. In COVID-19, CD8 + resident-memory (T RM ) CD4 T-helper-17 H17 cells undergo active (presumably antigen-driven) expansion towards end trajectory, are characterized by good effector functions, while they remain more naïve. Vice versa, T-cells T-helper-1 characteristics H1 -like) expressing exhaustion markers EX enriched halfway their where also exhibit show evidence inflammation-associated stress at trajectories. Monocyte-to-macrophage that chronic hyperinflammatory monocytes alveolar macrophages, otherwise anti-inflammatory antigen-presenting characteristics, depleted. contribute an ATP-purinergic signaling-inflammasome footprint could enable associated fibrosis disease-severity. Finally, viral RNA-tracking reveals infected lung epithelial cells, a significant proportion neutrophils macrophages involved clearance.

Язык: Английский

Процитировано

330
Metal Drugs and the Anticancer Immune Response DOI
Bernhard Englinger, Christine Pirker, Petra Heffeter

и другие.

Chemical Reviews, Год журнала: 2018, Номер 119(2), С. 1519 - 1624

Опубликована: Ноя. 29, 2018

The immune system deploys a multitude of innate and adaptive mechanisms not only to ward off pathogens but also prevent malignant transformation ("immune surveillance"). Hence, clinically apparent tumor already reflects selection for those cell clones capable evading recognition evasion"). Metal drugs, besides their well-investigated cytotoxic anticancer effects, massively interact with the cancer-immune interface can reverse important aspects evasion. This topic has recently gained intense attention based on combination approaches immunotherapy (e.g., checkpoint inhibitors), strategy delivering first exciting results in clinical settings. review summarizes promising still extremely fragmentary knowledge interplay metal drugs fidelity responses role adverse effects. It highlights that, at least some cases, induce long-lasting responses. Important steps this process comprise altered visibility susceptibility cancer cells toward immunity, as well direct impacts populations microenvironment. On basis gathered information, we suggest initiating joint multidisciplinary programs implement comprehensive analyses into strategies develop novel smart compounds.

Язык: Английский

Процитировано

308