
Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)
Опубликована: Авг. 1, 2022
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)
Опубликована: Авг. 1, 2022
Язык: Английский
Nature Immunology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 22, 2025
Abstract The rapid onset of innate immune defenses is critical for early control viral replication in an infected host and yet it can also lead to irreversible tissue damage, especially the respiratory tract. Sensitive regulators must exist that modulate inflammation, while controlling infection. In present study, we identified acetylcholine (ACh)-producing B cells as such regulators. are most prevalent ACh-producing leukocyte population tract demonstrated with choline acetyltransferase (ChAT)-green fluorescent protein (GFP) reporter mice, both before after infection influenza A virus. Mice lacking ChAT cells, disabling their ability generate ACh (ChatBKO), but not those T significantly, selectively directly suppressed α7-nicotinic-ACh receptor-expressing interstitial, alveolar, macrophage activation secrete tumor necrosis factor (TNF), better virus at 1 d postinfection. Conversely, TNF blockade via monoclonal antibody treatment increased loads time. By day 10 infection, ChatBKO mice showed local systemic inflammation reduced signs lung epithelial repair despite similar clearance. Thus, key participants immediate regulatory cascade controls damage shifting balance toward cost enhanced replication.
Язык: Английский
Процитировано
2Nature Communications, Год журнала: 2022, Номер 13(1)
Опубликована: Июнь 7, 2022
Abstract Checkpoint blockade with Pembrolizumab, has demonstrated durable clinical responses in advanced non-small cell lung cancer, however, treatment is offset by the development of high-grade immune related adverse events (irAEs) some patients. Here, we show that these patients a deficient Breg checkpoint fails to limit self-reactive T enhanced activity and auto-antibody formation enabled PD-1/PD-L1 blockade, leading severe auto-inflammatory sequelae. Principally failure IL-10 producing regulatory B cells as through functional ex vivo assays deep phenotyping mass cytometric analysis, major significant finding who develop irAEs when undergoing anti-PD1/PD-L1 blockade. There currently lack biomarkers identify priori those at greatest risk developing syndrome. Pre-therapy profiling could provide an important tool cancer high on
Язык: Английский
Процитировано
37Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Июль 7, 2023
The incidence of Diabetes Mellitus is increasing globally. Individuals who have been burdened with diabetes for many years often develop complications as a result hyperglycemia. More and more research being conducted highlighting inflammation an important factor in disease progression. In all kinds diabetes, hyperglycemia leads to activation alternative glucose metabolic pathways, resulting problematic by-products including reactive oxygen species advanced glycation end products. This review takes look into the pathogenesis three specific diabetic complications; retinopathy, nephropathy neuropathy well their current treatment options. By considering recent papers investigating effects immunotherapy on relevant conditions animal models, multiple strategies are suggested future prevention emphasis molecular targets associated inflammation.
Язык: Английский
Процитировано
23Clinical and Experimental Rheumatology, Год журнала: 2023, Номер unknown
Опубликована: Июнь 19, 2023
Язык: Английский
Процитировано
19Parasitology Research, Год журнала: 2025, Номер 124(1)
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2025, Номер unknown, С. 167675 - 167675
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Март 8, 2023
Activation of CD4 T cells by B has been extensively studied, but cell-regulated priming, proliferation, and survival CD8 remains controversial. express high levels MHC class I molecules can potentially act as antigen-presenting (APCs) for cells. Several in vivo studies mice humans demonstrate the role modulators cell function context viral infections, autoimmune diseases, cancer allograft rejection. In addition, B-cell depletion therapies lead to impaired T-cell responses. this review, we attempt answer 2 important questions: 1. antigen presentation cytokine production regulation fate determination, 2. The formation maintenance memory.
Язык: Английский
Процитировано
14Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Сен. 12, 2023
Systemic lupus erythematosus (SLE) is a heterogeneous multisystem inflammatory disease with wide variability in clinical manifestations. Natural arising CD4+ regulatory T cells (Tregs) play critical role maintaining peripheral tolerance by suppressing inflammation and preventing autoimmune responses SLE. Additionally, CD8+ cells, type 1 (Tr1), B also have less well-defined the pathogenesis of Elucidation roles various Treg subsets dedicated to immune homeostasis will provide novel therapeutic approach that governs for remission active lupus. Diminished interleukin (IL)-2 production associated depleted cell population, its reversibility IL-2 therapy provides important reasons treatment This review focuses on new therapeutics human low-dose benefits
Язык: Английский
Процитировано
14Oncogene, Год журнала: 2021, Номер 40(29), С. 4737 - 4745
Опубликована: Июнь 29, 2021
Язык: Английский
Процитировано
32Neurobiology of Disease, Год журнала: 2023, Номер 180, С. 106077 - 106077
Опубликована: Март 11, 2023
Acute injury to the central nervous system (CNS) remains a complex and challenging clinical need. CNS initiates dynamic neuroinflammatory response, mediated by both resident infiltrating immune cells. Following primary injury, dysregulated inflammatory cascades have been implicated in sustaining pro-inflammatory microenvironment, driving secondary neurodegeneration development of lasting neurological dysfunction. Due multifaceted nature clinically effective therapies for conditions such as traumatic brain (TBI), spinal cord (SCI), stroke proven develop. No therapeutics that adequately address chronic component are currently available. Recently, B lymphocytes gained increasing appreciation their role maintaining homeostasis regulating responses context tissue injury. Here we review response with particular focus on underexplored cells summarize recent results use purified novel immunomodulatory therapeutic particularly CNS.
Язык: Английский
Процитировано
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