Small intestinal derived Prevotella histicola simulates biologic as a therapeutic agent DOI Creative Commons
Baskar Balakrishnan, Stephen Johnson,

David Luckey

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 25, 2024

A role of gut microbiome in pathogenesis as well response to treatment is documented rheumatoid arthritis. Using a novel duodenal derived Prevotella histicola strain MCI 001, we have shown that it suppresses disease progression collagen-induced arthritis (CIA), model for (RA) using humanized mice expressing HLA-DQ8 gene the absence endogenous class II genes. Here compared efficacy P. 001 with tumor necrosis factor inhibitor (TNFi) treating DQ8 arthritic treated by oral gavage or TNFi, were onset, incidence and severity. We demonstrate mimics TNFi mice. pangenome comparison our its closest available neighbors depicted unique sequences may contribute immune modulatory effects. Notably, possesses sequence an outer membrane protein, BtuB, which involved vitamin B12 transport. Our data indicate MC001 attractive candidate prevent RA patients ongoing disease.

Язык: Английский

Gut Microbes as the Major Drivers of Rheumatoid Arthritis: Our Microbes Are Our Fortune! DOI Creative Commons
Veena Taneja

Microorganisms, Год журнала: 2025, Номер 13(2), С. 255 - 255

Опубликована: Янв. 24, 2025

Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiology. While certain genes provide strong susceptibility factors, the role of environmental factors becoming increasingly recognized. Among genetic human leukocyte antigen (HLA) genes, encoded within major histocompatibility complex (MHC), have been linked to predisposition RA, while among smoking, infections and diet are contributors. Genetic impact microbial composition in host. Based on dysbiosis observed gut lung microbiome, a mucosal origin RA has suggested. However, proving whether or microbes stronger risk factor difficult. Studies from patients various mouse models, specifically humanized mice expressing HLA class II instrumental defining such as smoking endogenous small intestinal modulating severity. The consensus based most studies support interaction between host onset severity disease. until now, no markers for prognosis treatment efficacy available. Here, severity, potential using commensals immune responses suppress inflammation context discussed.

Язык: Английский

Процитировано

0
Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders DOI
Azhagu Madhavan Sivalingam

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

0
Fuzi alleviates cold-related rheumatoid arthritis via regulating gut microbiota and microbial bile acid metabolism DOI Creative Commons
Juan Liu, Dandan Zhang,

Yaochuan Zhou

и другие.

Chinese Medicine, Год журнала: 2025, Номер 20(1)

Опубликована: Май 15, 2025

Язык: Английский

Процитировано

0
Autoimmunity and the microbiome DOI
Laura M. Cox, Vijay Kuchroo

Immunological Reviews, Год журнала: 2024, Номер 325(1), С. 4 - 8

Опубликована: Июль 9, 2024

Язык: Английский

Процитировано

2
Small intestinal derived Prevotella histicola simulates biologic as a therapeutic agent DOI Creative Commons
Baskar Balakrishnan, Stephen Johnson,

David Luckey

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 25, 2024

A role of gut microbiome in pathogenesis as well response to treatment is documented rheumatoid arthritis. Using a novel duodenal derived Prevotella histicola strain MCI 001, we have shown that it suppresses disease progression collagen-induced arthritis (CIA), model for (RA) using humanized mice expressing HLA-DQ8 gene the absence endogenous class II genes. Here compared efficacy P. 001 with tumor necrosis factor inhibitor (TNFi) treating DQ8 arthritic treated by oral gavage or TNFi, were onset, incidence and severity. We demonstrate mimics TNFi mice. pangenome comparison our its closest available neighbors depicted unique sequences may contribute immune modulatory effects. Notably, possesses sequence an outer membrane protein, BtuB, which involved vitamin B12 transport. Our data indicate MC001 attractive candidate prevent RA patients ongoing disease.

Язык: Английский

Процитировано

2