Gut Microbes as the Major Drivers of Rheumatoid Arthritis: Our Microbes Are Our Fortune!
Microorganisms,
Год журнала:
2025,
Номер
13(2), С. 255 - 255
Опубликована: Янв. 24, 2025
Rheumatoid
arthritis
(RA)
is
an
autoimmune
disease
with
unknown
etiology.
While
certain
genes
provide
strong
susceptibility
factors,
the
role
of
environmental
factors
becoming
increasingly
recognized.
Among
genetic
human
leukocyte
antigen
(HLA)
genes,
encoded
within
major
histocompatibility
complex
(MHC),
have
been
linked
to
predisposition
RA,
while
among
smoking,
infections
and
diet
are
contributors.
Genetic
impact
microbial
composition
in
host.
Based
on
dysbiosis
observed
gut
lung
microbiome,
a
mucosal
origin
RA
has
suggested.
However,
proving
whether
or
microbes
stronger
risk
factor
difficult.
Studies
from
patients
various
mouse
models,
specifically
humanized
mice
expressing
HLA
class
II
instrumental
defining
such
as
smoking
endogenous
small
intestinal
modulating
severity.
The
consensus
based
most
studies
support
interaction
between
host
onset
severity
disease.
until
now,
no
markers
for
prognosis
treatment
efficacy
available.
Here,
severity,
potential
using
commensals
immune
responses
suppress
inflammation
context
discussed.
Язык: Английский
Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders
Clinical Reviews in Allergy & Immunology,
Год журнала:
2025,
Номер
68(1)
Опубликована: Фев. 11, 2025
Язык: Английский
Fuzi alleviates cold-related rheumatoid arthritis via regulating gut microbiota and microbial bile acid metabolism
Chinese Medicine,
Год журнала:
2025,
Номер
20(1)
Опубликована: Май 15, 2025
Язык: Английский
Autoimmunity and the microbiome
Immunological Reviews,
Год журнала:
2024,
Номер
325(1), С. 4 - 8
Опубликована: Июль 9, 2024
Язык: Английский
Small intestinal derived Prevotella histicola simulates biologic as a therapeutic agent
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 25, 2024
A
role
of
gut
microbiome
in
pathogenesis
as
well
response
to
treatment
is
documented
rheumatoid
arthritis.
Using
a
novel
duodenal
derived
Prevotella
histicola
strain
MCI
001,
we
have
shown
that
it
suppresses
disease
progression
collagen-induced
arthritis
(CIA),
model
for
(RA)
using
humanized
mice
expressing
HLA-DQ8
gene
the
absence
endogenous
class
II
genes.
Here
compared
efficacy
P.
001
with
tumor
necrosis
factor
inhibitor
(TNFi)
treating
DQ8
arthritic
treated
by
oral
gavage
or
TNFi,
were
onset,
incidence
and
severity.
We
demonstrate
mimics
TNFi
mice.
pangenome
comparison
our
its
closest
available
neighbors
depicted
unique
sequences
may
contribute
immune
modulatory
effects.
Notably,
possesses
sequence
an
outer
membrane
protein,
BtuB,
which
involved
vitamin
B12
transport.
Our
data
indicate
MC001
attractive
candidate
prevent
RA
patients
ongoing
disease.
Язык: Английский