Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy DOI Creative Commons

Z.C. Chen,

Rayk Behrendt,

Lennart Wild

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Март 19, 2025

Abstract Nucleic acids from both self- and non-self-sources act as vital danger signals that trigger immune responses. Critical illnesses such acute respiratory distress syndrome, sepsis, trauma ischemia lead to the aberrant cytosolic accumulation massive release of nucleic are detected by antiviral innate receptors in endosome or cytosol. Activation for deoxyribonucleic ribonucleic triggers inflammation, a major contributor morbidity mortality critically ill patients. In past decade, there has been growing recognition therapeutic potential targeting acid sensing critical care. This review summarizes current knowledge ischemia. Given extensive research on common pathological conditions like cancer, autoimmune disorders, metabolic disorders aging, we provide comprehensive summary beyond illness offer insights may inform its role conditions. Additionally, discuss strategies specifically target sensing. By examining sources, sensor activation function, well impact regulating these pathways across various diseases, highlight driving illness.

Язык: Английский

Innate Immune Sensors in Health and Disease DOI Open Access
Prajwal Gurung

Immunological Reviews, Год журнала: 2025, Номер 330(1)

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

0
U-shaped association between plasma cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) levels and myocardial infarction DOI Creative Commons
Quan Zhang, Huiqing Ding, Zhehao Dai

и другие.

BMC Cardiovascular Disorders, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 19, 2025

The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway is closely associated with myocardial infarction (MI). Cyclic (cGAMP) a key component this pathway; however, there currently lack clinical evidence linking plasma cGAMP levels to MI. This study utilized data from 270 patients diagnosed coronary heart disease (CHD) at the Second Xiangya Hospital Central South University. outcomes included ST-segment elevation and non-ST-segment Univariate multivariate logistic regression models were used explore relationships between MI, while restricted cubic spline (RCS) using dose-response relationship. Among patients, mean level was 1352.58 ± 106.02 ng/L 89 (32.96%) RCS curves indicated U-shape association MI; risk MI negatively correlated until it hit bottoms 1352 ng/L. When exceeded ng/L, increased significantly (adjusted OR, 1.02; 95% CI: 1.01–1.03). considering as categorical variable, in Tertile 1 3 had 167% OR: 2.67, 1.23–5.78) 155% 2.55, 1.17–5.55) higher compared those 2, respectively. These results consistent across subgroup analyses, notably, significant interaction by age category observed ≥ where positive pronounced elderly. A U-shaped exists CHD population, cutoff point Both excessively high low are an particularly among elderly first cGAS-cGAMP-STING metabolic cardiovascular diseases. NCT03363035 (Registration date: 2018-01-15).

Язык: Английский

Процитировано

0
A short history of the atrial NLRP3 inflammasome and its distinct role in atrial fibrillation DOI Creative Commons

Theresa Poppenborg,

Arnela Saljic, Florian Bruns

и другие.

Journal of Molecular and Cellular Cardiology, Год журнала: 2025, Номер 202, С. 13 - 23

Опубликована: Март 6, 2025

Inflammasomes are multiprotein complexes of the innate immune system that mediate inflammatory responses to infection and local systemic stress tissue injury. The principal function is facilitate caspase-1 auto-activation subsequently maturation release effectors interleukin (IL)-1β IL-18. atrial-specific NLRP3 inflammasome a unifying causal feature atrial fibrillation (AF) development, progression recurrence after ablation. Many AF-associated risk factors co-morbidities converge mechanistically on activation this central signaling platform. This review presents historical conceptual development distinct its potential involvement in AF. We follow early observations linking inflammation with AF, emergence an atrial-intrinsic operating within not just cells but also resident fibroblasts cardiomyocytes. outline key developments understanding how effector IL-1β contribute causally cellular tissue-level arrhythmogenesis different pathological settings, candidate therapeutic concepts verified preclinical models cardiomyopathy

Язык: Английский

Процитировано

0
Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy DOI Creative Commons

Z.C. Chen,

Rayk Behrendt,

Lennart Wild

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Март 19, 2025

Abstract Nucleic acids from both self- and non-self-sources act as vital danger signals that trigger immune responses. Critical illnesses such acute respiratory distress syndrome, sepsis, trauma ischemia lead to the aberrant cytosolic accumulation massive release of nucleic are detected by antiviral innate receptors in endosome or cytosol. Activation for deoxyribonucleic ribonucleic triggers inflammation, a major contributor morbidity mortality critically ill patients. In past decade, there has been growing recognition therapeutic potential targeting acid sensing critical care. This review summarizes current knowledge ischemia. Given extensive research on common pathological conditions like cancer, autoimmune disorders, metabolic disorders aging, we provide comprehensive summary beyond illness offer insights may inform its role conditions. Additionally, discuss strategies specifically target sensing. By examining sources, sensor activation function, well impact regulating these pathways across various diseases, highlight driving illness.

Язык: Английский

Процитировано

0