Immunomodulatory effects of 4-hydroxynonenal DOI Creative Commons
Melina Ioannidis,

Johanna Tjepkema,

Michael R.P. Uitbeijerse

и другие.

Redox Biology, Год журнала: 2025, Номер 85, С. 103719 - 103719

Опубликована: Июнь 6, 2025

The reactive aldehyde 4-hydroxy-2-nonenal (4-HNE) is a byproduct of lipid peroxidation driven by oxygen species (ROS). 4-HNE covalently binds to macromolecules such as proteins, altering their functions. While implicated in various ROS-related pathologies, its impact on the immune system remains incompletely understood. This review explores how influences molecular mechanisms involved inflammation and cell modulates through interaction with several signaling pathways, including nuclear factor kappa-light-chain enhancement activated B cells (NF-κB), erythroid 2-related (Nrf2), mitogen-activated protein kinases (MAPK), toll-like receptor (TLR) 4, stimulator interferon genes (STING), thereby affecting responses modulating cytokine production inflammasome activation. However, effects are complex, exhibiting both pro- anti-inflammatory properties depending dose type. highlights multiple which cells' responses.

Язык: Английский

Deciphering the role of cell signaling pathways in gout pathogenesis and the therapeutic potential of phytoconstituents in their modulation DOI
Hrithik Dey, Syed Salman Ali, Vandana Arora Sethi

и другие.

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

Язык: Английский

Процитировано

1
Innate Immune Sensors in Health and Disease DOI Open Access
Prajwal Gurung

Immunological Reviews, Год журнала: 2025, Номер 330(1)

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

0
Immunomodulatory effects of 4-hydroxynonenal DOI Creative Commons
Melina Ioannidis,

Johanna Tjepkema,

Michael R.P. Uitbeijerse

и другие.

Redox Biology, Год журнала: 2025, Номер 85, С. 103719 - 103719

Опубликована: Июнь 6, 2025

The reactive aldehyde 4-hydroxy-2-nonenal (4-HNE) is a byproduct of lipid peroxidation driven by oxygen species (ROS). 4-HNE covalently binds to macromolecules such as proteins, altering their functions. While implicated in various ROS-related pathologies, its impact on the immune system remains incompletely understood. This review explores how influences molecular mechanisms involved inflammation and cell modulates through interaction with several signaling pathways, including nuclear factor kappa-light-chain enhancement activated B cells (NF-κB), erythroid 2-related (Nrf2), mitogen-activated protein kinases (MAPK), toll-like receptor (TLR) 4, stimulator interferon genes (STING), thereby affecting responses modulating cytokine production inflammasome activation. However, effects are complex, exhibiting both pro- anti-inflammatory properties depending dose type. highlights multiple which cells' responses.

Язык: Английский

Процитировано

0