Admission respiratory status predicts mortality in COVID‐19

Influenza and Other Respiratory Viruses, Год журнала: 2021, Номер 15(5), С. 569 - 572

Опубликована: Май 24, 2021

COVID-19 has significant case fatality. Glucocorticoids are the only treatment shown to improve survival, but among patients requiring supplemental oxygen. WHO advises seek medical care for "trouble breathing," hypoxemic frequently have no respiratory symptoms. Our cohort study of hospitalized shows that symptoms uncommon and not associated with mortality. By contrast, objective signs compromise-oxygen saturation rate-are markedly elevated findings support expanding guidelines include at-home assessment oxygen rate in order expedite life-saving treatments high-risk patients.

Язык: Английский

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Early versus late awake prone positioning in non-intubated patients with COVID-19

Critical Care, Год журнала: 2021, Номер 25(1)

Опубликована: Сен. 17, 2021

Awake prone positioning (APP) is widely used in the management of patients with coronavirus disease (COVID-19). The primary objective this study was to compare outcome COVID-19 who received early versus late APP.Post hoc analysis data collected for a randomized controlled trial (ClinicalTrials.gov NCT04325906). Adult acute hypoxemic respiratory failure secondary APP at least one hour were included. Early defined as initiated within 24 h high-flow nasal cannula (HFNC) start. Primary outcomes 28-day mortality and intubation rate.We included 125 (79 male) mean age 62 years. Of them, 92 (73.6%) 33 (26.4%) APP. Median time from HFNC initiation 2.25 (0.8-12.82) vs 36.35 (30.2-75.23) hours group (p < 0.0001), respectively. Average duration 5.07 (2.0-9.05) 3.0 (1.09-5.64) per day had lower compared (26% 45%, p = 0.039), but no difference found rate. Advanced (OR 1.12 [95% CI 1.0-1.95], 0.001), 10.65 2.77-40.91], longer initiate 1.02 1.0-1.04], 0.047) hydrocortisone use 6.2 1.23-31.1], 0.027) associated increased mortality.Early (< use) improves survival. Trial registration ClinicalTrials.gov NCT04325906.

Язык: Английский

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High mortality among hospitalized adult patients with COVID-19 pneumonia in Peru: A single centre retrospective cohort study

PLoS ONE, Год журнала: 2022, Номер 17(3), С. e0265089 - e0265089

Опубликована: Март 8, 2022

Peru is the country with world's highest COVID-19 death rate per capita. Characteristics associated increased mortality among adult patients pneumonia in this setting are not well described.Retrospective, single-center cohort study including 1537 hospitalized a diagnosis of SARS-CoV-2 between May 2020 and August at national hospital Lima, Peru. The primary outcome measure was in-hospital mortality.In-hospital 49.71%. mean age 60 ± 14.25 years, 68.38% were males. We found an association inflammatory markers, mainly leukocytes, D-dimer, lactate dehydrogenase, C-reactive protein ferritin. A multivariate model adjusted for age, hypertension, diabetes mellitus, corticosteroid use demonstrated that greater (RR: 2.01, 95%CI: 1.59-2.52) higher level oxygen requirement 2.77, 2.13-3.62). Conclusions: In-hospital high requirements.

Язык: Английский

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Study of Albumin Oxidation in COVID-19 Pneumonia Patients: Possible Mechanisms and Consequences

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(17), С. 10103 - 10103

Опубликована: Сен. 3, 2022

Oxidative stress induced by neutrophils and hypoxia in COVID-19 pneumonia leads to albumin modification. This may result elevated levels of advanced oxidation protein products (AOPPs) lipoxidation end-products (ALEs) that trigger oxidative bursts thus participate cytokine storms, accelerating endothelial lung cell injury, leading respiratory distress. In this study, sixty-six hospitalized patients with symptoms were studied. AOPPs-HSA was produced vitro treating human serum (HSA) chloramine T. The interaction malondialdehyde HSA studied using time-resolved fluorescence spectroscopy. findings revealed a significantly level AOPPs on admission the hospital one week later as long they acute phase infection when compared values recorded for same 6- 12-months post-infection. Significant negative correlations positive with, e.g., procalcitonin, D-dimers, lactate dehydrogenase, aspartate transaminase, radiological scores computed tomography (HRCT), observed. AOPPs/albumin ratio found be strongly correlated D-dimers. We suggest oxidized could involved pathophysiology. Some possible clinical consequences modification are also discussed.

Язык: Английский

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Remote Photoplethysmography Is an Accurate Method to Remotely Measure Respiratory Rate: A Hospital-Based Trial

Journal of Clinical Medicine, Год журнала: 2022, Номер 11(13), С. 3647 - 3647

Опубликована: Июнь 24, 2022

Remote photoplethysmography imaging (rPPG) is a new solution proposed to measure vital signs, such as respiratory rate (RR) in teleconsultation, by using webcam. The results, presented here, aim at evaluating the accuracy of remote measurement methods, compared with existing real-life clinical setting. For each patient, RR, standard system (control), has been carried out concomitantly experimental system. A 60-s time frame was used for measurements made our rPPG Age, gender, BMI, and skin phototype were collected. We performed intraclass correlation coefficient Bland-Altman plot analyze precision algorithm readings. Measurements two have realized on 963 patients. Comparison techniques showed excellent agreement (96.0%), most patients (n = 924-standard patients) being confidence interval 95% plotting. There no significant differences between outlier demographic characteristics. This study indicates good control, thus allowing use this assessment rate.

Язык: Английский

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Predictors of mortality in hospitalised patients with COVID-19: a 1-year case–control study

BMJ Open, Год журнала: 2024, Номер 14(2), С. e072784 - e072784

Опубликована: Фев. 1, 2024

Background A paucity of predictive models assessing risk factors for COVID-19 mortality that extend beyond age and gender in Latino population is evident the current academic literature. Objectives To determine associated with mortality, addition to sex during first year pandemic. Design case–control study retrospective revision clinical paraclinical variables by systematic records was conducted. Multiple imputations chained equation were implemented account missing variables. Classification regression trees (CART) estimated evaluate interaction on admission their role predicting hospitalisation. No intervention performed. Setting High-complexity centre above 2640 m sea level (masl) Colombia. Participants sample 564 patients admitted hospital confirmed PCR. Deceased (n=282) a control group (n=282), matched age, month admission, included. Main outcome measure Mortality results After imputation datasets, CART analysis 11 profiles based respiratory distress, haemoglobin, lactate dehydrogenase, partial pressure oxygen inspired ratio, chronic kidney disease, ferritin, creatinine leucocytes admission. The accuracy model prediction 80.4% (95% CI 71.8% 87.3%), an area under curve 78.8% 69.63% 87.93%). Conclusions This discloses new interactions between features influencing patients. Furthermore, could offer clues personalised management this condition settings.

Язык: Английский

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Wrangling Real-World Data: Optimizing Clinical Research Through Factor Selection with LASSO Regression

International Journal of Environmental Research and Public Health, Год журнала: 2025, Номер 22(4), С. 464 - 464

Опубликована: Март 21, 2025

Data-driven approaches to clinical research are necessary for understanding and effectively treating infectious diseases. However, challenges such as issues with data validity, lack of collaboration, difficult-to-treat diseases (e.g., those that rare or newly emerging) hinder research. Prioritizing innovative methods facilitate the continued use generated during routine care research, but in an organized, accelerated, shared manner, is crucial. This study investigates potential CURE ID, open-source platform accelerate drug-repurposing diseases, COVID-19 a case. Data from eight US health systems were analyzed using least absolute shrinkage selection operator (LASSO) regression identify key predictors 28-day all-cause mortality patients, including demographics, comorbidities, treatments, laboratory measurements captured first two days hospitalization. Key findings indicate age, measures, severity illness indicators, oxygen support administration, comorbidities significantly influenced mortality, aligning previous studies. work underscores value collaborative repositories like ID providing robust datasets prognostic importance factor identifying variables, helping streamline future efforts.

Язык: Английский

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Effectiveness and safety of normoxic allogenic umbilical cord mesenchymal stem cells administered as adjunctive treatment in patients with severe COVID-19

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Авг. 2, 2023

Inflammatory response in COVID-19 contributes greatly to disease severity. Mesenchymal Stem Cells (MSCs) have the potential alleviate inflammation and reduce mortality length of stay patients. We investigated safety effectiveness normoxic-allogenic umbilical cord (NA-UC)-MSCs as an adjunctive treatment severe A double-blind, multicentric, randomized, placebo-controlled trial involving patients was performed from January June 2021 three major hospitals across Java, Indonesia. Eligible participants (n = 42) were randomly assigned two groups (1:1), namely intervention 21) control groups. UC-MSCs dose 1 × 106 /kg body weight on day D0, D3, D6. The primary outcome duration hospitalization. Meanwhile, secondary outcomes radiographical progression (Brixia score), respiratory oxygenation parameters, inflammatory markers, addition profile NA-UC-MSCs. NA-UC-MSCs administration did not affect hospital patients, nor it improve Brixia score or mMRC dyspnoea scale better than placebo. Nevertheless, led a recuperation index (120.80 ± 72.70 baseline vs. 309.63 319.30 D + 22, p 0.038) oxygen saturation (97.24 4.10% 96.19 3.75% placebo, 0.028). Additionally, compared placebo group, group had significantly smaller increase PCT level at 22 (1.43 12.76, 0.011). No adverse effects, including serious ones, recorded until 91. therapy is very safe adjunct for It improves carries suppress inflammation.

Язык: Английский

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Combined systemic inflammatory indexes as reflectors of outcome in patients with COVID‑19 infection admitted to ICU

Inflammopharmacology, Год журнала: 2023, Номер 31(5), С. 2337 - 2348

Опубликована: Авг. 7, 2023

Язык: Английский

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Safety and efficacy of inhaled IBIO123 for mild-to-moderate COVID-19: a randomised, double-blind, dose-ascending, placebo-controlled, phase 1/2 trial

The Lancet Infectious Diseases, Год журнала: 2023, Номер unknown

Опубликована: Авг. 1, 2023

Язык: Английский

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