Adjuvant pomegranate juice intake improves the inflammatory status of hospitalized COVID-19 patients: A randomized and placebo-controlled trial

Complementary Therapies in Medicine, Год журнала: 2023, Номер 75, С. 102958 - 102958

Опубликована: Июнь 3, 2023

This study aimed to evaluate the effect of pomegranate juice intake on inflammatory status and complete blood count in hospitalized Covid-19 patients. randomized, double-blinded placebo-controlled trial included 48 patients with two parallel arms. In addition standard care provided at hospital, consumed 500 mL whole (PJ) daily or a placebo for 14 days. Inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR)) were determined baseline after days intervention. At end intervention, significant decreased was observed primary outcomes [mean difference (95 %CI)] including IL-6 [5.24(0.87–9.61)], CRP [23.19(11.93–34.44)] ESR [10.52(1.54–19.50)] PJ group vs. before addition, changes also some secondary outcomes, neutrophils, lymphocytes, platelets, platelets-to-lymphocyte(PLR) neutrophils-to-lymphocyte (NLR) ratios (p < 0.05) compared intervention period, mean change [− 7.09(−12.21 − 1.96)], white cells 3.09(− 6.14 0.05)], neutrophils 9.12(−18.08 −0.15)], lymphocyte [7.05(0.17–13.92)], platelets 94.54(− 139.33 49.75)], PLR 15.99(− 29.31 2.67)], oxygen saturation [1.75(0.13–3.37)] MCV [0.31(− 0.25 0.88)] levels significantly different between groups while no other indices. Our results suggest that might slightly improve CBC COVID-19 it may be beneficial.

Язык: Английский

---

COVID-19 patients hospitalized after the fourth wave of the pandemic period in Vietnam: Clinical, laboratory, therapeutic features, and clinical outcomes

Journal of the Formosan Medical Association, Год журнала: 2023, Номер 123(2), С. 208 - 217

Опубликована: Авг. 12, 2023

Despite having relatively high COVID-19 vaccine coverage in Vietnam, a fraction of patients required hospitalization due to severe symptoms. The purpose this study was describe the clinical, laboratory, complications, and treatment hospitalized during pandemic's fourth wave. Genome sequencing performed on patients. Data clinical characteristics, treatment, outcomes were consistently collected. classifications mild (37.43%), moderate (24.2%), (38.37%). Patients with co-morbidities, fever >39 °C, hypertension, tachycardia, tachypnea, SpO2<90%, had 1.2–4 folds higher progression than those mild/moderate. Serious consequences much more common respiratory system generally documented as fine, coarse crackles, CT scanner shown ground glass, consolidation, opacity, Delta variant accounting for 92.6%. Complications patients, including bacteria pneumonia (36.42%), ARDS (61.11%), blood clotting disorder (7.14%), infection (46.92%), acute kidney injury (12.35%). Antiviral, antifungal, corticosteroid, anticoagulant, ECMO regimens utilized. died mostly result low SpO2, lung injury, complications such bacterial + fungal (83.9%), bacteremia (56.5%), renal failure (27.4%), coagulopathy (12.9%). Severe critical frequently have several comorbidities, multiple lesions along variety signs. receiving antivirals, antibiotics, corticosteroids, anticoagulants, even therapy, patient encountered fatality rate up 38.27%.

Язык: Английский

---

Clinical Characteristics, Prognosis Factors and Metagenomic Next-Generation Sequencing Diagnosis of Mucormycosis in patients With Hematologic Diseases

Mycopathologia, Год журнала: 2024, Номер 189(4)

Опубликована: Авг. 1, 2024

Язык: Английский

---

Racial and Ethnic Differences in Hospital Admissions of Emergency Department COVID-19 Patients

Medical Care, Год журнала: 2022, Номер 60(6), С. 415 - 422

Опубликована: Март 22, 2022

Several studies have found that among patients testing positive for COVID-19 within a health care system, non-Hispanic Black and Hispanic are more likely than White to be hospitalized. However, previous looked at odds of being admitted using all tests in the system not only those seeking emergency department (ED).This study examined racial/ethnic differences hospitalizations intensive unit (ICU) admissions ED.Electronic records (n=7549) were collected from confirmed visited an ED urban Chicago area between March 2020 February 2021.After adjusting possible confounders, had 2.2 times hospital 1.5 ICU patients. There no observed patients.White hospitalized after presenting with directly ICU. This finding may due severity disease upon presentation, racial ethnic access primary and/or implicit bias impacting clinical decision-making.

Язык: Английский

---

Effect of Ward-Based High-Flow Nasal Cannula (HFNC) Oxygen Therapy on Critical Care Utilization During the COVID-19 Pandemic: A Retrospective Cohort Analysis

Journal of General Internal Medicine, Год журнала: 2023, Номер 38(5), С. 1160 - 1166

Опубликована: Янв. 20, 2023

Язык: Английский

---

Clinical courses of 24,563 hospitalized COVID-19 patients during the first 12 months of the pandemic in the Central City of Iran

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Апрель 21, 2023

Abstract This study was designed and implemented to analyze establish documents related the above cases in first third COVID-19 epidemic waves for use of researchers doctors during after epidemic. The current case series conducted on 24,563 thousand hospitalized patients by examining their clinical characteristics within a one-year period from beginning pandemic 02.22.2020 02.14.2021, which included waves, based gender severity COVID-19. mean age participants 56 ± 20.71, 51.8% were male. Out total until February 2021, there 2185 mortalities (9.8%) 2559 severe (13.1%). median length hospitalization time admission discharge or death hospital (IQR: 13–41) estimated be 21 days. rate mortality higher (37.8%) than non-severe (4.8%) COVID-19, While risk increased significantly (HR = 1.65, 95% CI: 1.46–1.87, P < 0.001) early fourth 2.145, 1.7–2.71, 0.001). Also, contracting aged ≥ 65 years old 2.1, CI 1.1.93–2.72, As shown results, rates (9.3% vs. 8.5%) (13.6% 12.5%) among men women ( 0.01). In our study, scope global studies. Men experienced women. prevalence underlying diseases individuals with Our data also showed that previous history had more experience while most these older an disease.

Язык: Английский

---

Heart/breathing rate ratio (HBR) as a predictor of mortality in critically ill patients

Heliyon, Год журнала: 2024, Номер 10(10), С. e31187 - e31187

Опубликована: Май 1, 2024

ObjectivesThe early prediction of death is a challenge for medical staff. We evaluated the ability heart/breathing rate ratio (HBR) to predict mortality.MethodsThis was single-center retrospective observational study adult patients who had fever with or without respiratory symptoms, survived at least 2 hours after visiting hospital, and whose lactate levels vital signs were tested. distribution mortality different HBR compared lactate.ResultsA total 18 872 clinic visits screened, 183 tested recruited. Patients values lower than 4·5 higher 5·5 greater between (21·3% vs. 3·4%, p=0·003; 28·9% p<0·001, respectively). In <5, AUROC 0·762 (95% CI: 0.643–0·880), that 0·701 0·564–0·837). ≥5, 0·721 0·584–0·857), 0·742 0·607–0·848).ConclusionsHBR helpful stratifying risk among critically ill in acute care clinics infectious diseases.

Язык: Английский

---

Outcomes of Hospitalised COVID-19 Patients Arriving With Hypoxic Respiratory Failure

Heart Lung and Circulation, Год журнала: 2024, Номер unknown

Опубликована: Июль 1, 2024

Язык: Английский

---

Characterization and determinant factors of critical illness and in-hospital mortality of COVID-19 patients: A retrospective cohort of 1,792 patients in Kenya

Biosafety and Health, Год журнала: 2022, Номер 4(5), С. 330 - 338

Опубликована: Июнь 28, 2022

Limited data is available on the coronavirus disease 2019 (COVID-19), critical illness rate, and in-hospital mortality in African setting. This study investigates determinants of among COVID-19 patients Kenya. We conducted a retrospective cohort at Kenyatta National Hospital (KNH) Multivariate logistic regression Cox proportional hazard were employed to determine predictor factors for intensive care unit (ICU) admission mortality, respectively. In addition, Kaplan-Meier model was used compare survival times using log-rank tests. As result, 346 (19.3%) admitted ICU, 271 (15.1%) died. The majority those hospital male, 1,137 (63.4%) asymptomatic, 1,357 (75.7%). most prevalent clinical features shortness breath, fever, dry cough. older age, health status, patient oxygen (O2), saturation levels (SPO2), headache, cough, comorbidities, obesity, cardiovascular diseases (CVDs), diabetes, chronic lung (CLD), malignancy/cancer can predicate risk ICU admission, with an area under receiver operating characteristic curve (AUC-ROC) 0.90 (95% confidence interval [CI]: 0.88-0.92). Survival analysis indicated died identified oxygen, SPO2, comorbidity, CVDs, CLD, malignancy/cancer, smoking as (AUC-ROC: 0.90, 95% CI: 0.89-0.91). first attempt explore predictors

Язык: Английский

---

Clinical Characteristics and Predictors of Mortality in Elderly Patients Hospitalized with COVID-19 in Bangladesh: A Multicenter, Retrospective Study

Interdisciplinary Perspectives on Infectious Diseases, Год журнала: 2022, Номер 2022, С. 1 - 10

Опубликована: Июнь 11, 2022

Elderly patients are at high risk of fatality from COVID-19. The present work aims to describe the clinical characteristics elderly inpatients with COVID-19 and identify predictors in-hospital mortality admission.In this retrospective, multicenter cohort study, we included (n = 245) four hospitals in Sylhet, Bangladesh, who had been discharged between October 2020 February 2021. Demographic, clinical, laboratory data were extracted hospital records compared survivors nonsurvivors. We used univariable multivariable logistic regression analysis explore factors associated death. Principal Results. Of patients, 202 (82.44%) 43 (17.55%) died hospital. Except hypertension, other comorbidities like diabetes, chronic kidney disease, ischemic heart obstructive pulmonary disease more prevalent Nonsurvivors a higher prevalence leukocytosis (51.2 versus 30.7; p=0.01), lymphopenia (72.1 55; p=0.05), thrombocytopenia (20.9 9.9; p=0.07). Multivariable showed an increasing odds ratio death older age (odds 1.05, 95% CI 1.01-1.10, per year increase; p=0.009), (OR 3.56; 1.22-10.33, p=0.019), admission SpO2 0.91, 0.88-0.95; p=0.001).Higher age, thrombocytopenia, lower initial level

Язык: Английский

---