Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Сен. 25, 2023

Abstract The role of gut microbiota in modulating the durability COVID-19 vaccine immunity is yet to be characterised. In this cohort study, we collected blood and stool samples 121 BNT162b2 40 CoronaVac vaccinees at baseline, 1 month, 6 months post vaccination (p.v.). Neutralisation antibody, plasma cytokine chemokines were measured associated with metabolome composition. A significantly higher level neutralising antibody (at p.v.) was found who had relative abundances Bifidobacterium adolescentis , bifidum Roseburia faecis as well concentrations nicotinic acid (Vitamin B) γ-Aminobutyric ( P < 0.05) baseline. high antibodies p.v. an increased abundance Phocaeicola dorei a lower Faecalibacterium prausnitzii concentration L-tryptophan also Dorea formicigenerans month among (Rho = 0.62, p 0.001, FDR 0.123). Of species altered following vaccination, 79.4% 42.0% groups, respectively, recovered months. Specific vaccinees, both bacteriome virome diversity depleted did not recover baseline (FDR 0.1). conclusion, study identified potential microbiota-based adjuvants that may extend immune responses SARS-CoV-2 vaccines.

Язык: Английский

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Evaluation of anti-SARS-CoV-2 RBD antibody response after booster dose of SpikoGen® in individuals with two previous doses of Sinopharm and its association with HLA-DR and -DQ alleles

Human Immunology, Год журнала: 2025, Номер 86(1), С. 111227 - 111227

Опубликована: Янв. 1, 2025

Язык: Английский

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The magnitude and cross reactivity of SARS-CoV-2 specific antibody responses in Sri Lankan children and association with the nutritional status

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Background In order to determine if undernutrition affects the presence, breadth and magnitude of antibodies SARS-CoV-2 variants, we studied specific antibody responses in a large island wide serosurvey children Sri Lanka. Methods Using WHO UNITY protocol, recruited 5207 children, aged 10 20 years, assessed anthropometric measures, seropositive rates, ACE2 blocking omicron vaccinated unvaccinated children. Results 3111/3119 (99.7%) 2008/2088 (96.2%) were for SARS-CoV-2, although detection significantly higher (2984/3111, 95.9%) compared (1346/2008, 67.0%). 1057 (22.1%) had BMI < 3rd centile age, therefore classified as underweight. Unvaccinated with lower than other groups. There no differences titres XBB.1.5 or BA.2.75 based on category. Conclusions The high seropositivity variants indicates possible multiple infections SARS-CoV-2. implications levels underweight should be further investigated.

Язык: Английский

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Exploring How Adipose Tissue, Obesity, and Gender Influence the Immune Response to Vaccines: A Comprehensive Narrative Review

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 862 - 862

Опубликована: Янв. 20, 2025

Vaccines represent an essential tool for the prevention of infectious diseases. Upon administration, a complex interaction occurs between vaccine formulation and recipient’s immune system, ultimately resulting in protection against disease. Significant variability exists individual population responses to vaccination, these differences remain focus ongoing research. Notably, well-documented factors, such as age, gender, genetic predisposition, influence responses. In contrast, effects overweight obesity have not been thoroughly investigated. The evidence indicates that high body mass index (BMI) constitutes significant risk factor infections general, with adipose tissue playing crucial role modulating response. Furthermore, suboptimal levels seroconversion observed among individuals obesity. This review provides plausible examination immunity conferred by various vaccines status, offering comprehensive analysis mechanisms enhance vaccination efficiency.

Язык: Английский

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Psychological correlates of antibody response to mRNA SARS-CoV-2 vaccination: A prospective observational cohort study

Brain Behavior and Immunity, Год журнала: 2025, Номер 127, С. 103 - 109

Опубликована: Март 11, 2025

Vaccines fundamentally changed the course of COVID-19 pandemic, saving > 14 million lives within a year. However, vaccine-conferred protection showed inter-individual variability, with many identified correlates (e.g., age) not amenable to change. This prospective observational cohort study examined whether modifiable psychological factors (depressive symptoms, anxiety, perceived stress and positive mood), which predict antibody responses other vaccines, also influenced effectiveness vaccines. We focussed on novel mRNA vaccines as these conferred greater clinical have been investigated in previously. One-hundred eighty-four adults attending mass-vaccination centre UK received two-dose BNT162b2 SARS-CoV-2 vaccine course, completed validated measures, provided blood samples prior vaccination 4 weeks following second dose. In separate linear regression models controlling for pre-vaccination levels, demographic factors, higher levels depressive symptoms (β = -0.15 [95 % CI: -0.30, -0.01], p 0.041, partial f2 0.009) lower mood 0.16 0.01, 0.30], 0.036, 0.011) were significantly associated spike-specific vaccination. No significant relationships observed between measures anxiety or responses. Lower larger community sample their first vaccinations. As both are change, they could offer mechanisms enhancing particularly among populations at risk failure.

Язык: Английский

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Long-term dynamics of SARS-CoV-2 immunity in a university hospital in Colombia: A cohort study

IJID Regions, Год журнала: 2025, Номер unknown, С. 100641 - 100641

Опубликована: Март 1, 2025

Язык: Английский

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Metabolic complications and clinical outcomes of non-functioning adrenal incidentalomas: a systematic review and meta-analysis

BMC Endocrine Disorders, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 7, 2025

Increased detection of non-functioning adrenal incidentalomas (NFAI) due to widespread abdominal imaging may underestimate associated metabolic risks. To examine NFAI's impact on comorbidities and evaluate outcomes in surgical non-surgical management, including changes NFAI characteristics during follow-up. Meta-analysis studies from PubMed, Embase, Cochrane Library, Web Science (January 2000 May 2024). Studies focusing patients with serum cortisol levels ≤ 50 nmol/L after 1 mg dexamethasone suppression test (DST). Prevalence hypertension, diabetes, obesity, lipid disorders before Tumor growth (> 10 mm increase) functional (1 DST retest) were assessed. Eighteen met inclusion criteria (n = 2,059). In the group, diabetes (RR: 1.33, 95% CI: 1.07-1.65) 1.22, 1.07-1.38) increased significantly, while hypertension 1.07, 0.99-1.16) obesity 1.05, 0.91-1.21) showed no significant change. Surgical intervention significantly improved 0.67, 0.52-0.86). During mean follow-up 46.1 months, 4% (95% 2%- 8%) enlarged > mm, 8% 5%- 14%) became 45.1 months NFAI, subtle hormone secretion exist despite current diagnostic suggesting non-functionality. Such tumors show associations disorders, particularly mellitus dyslipidemia. Future research should focus developing more sensitive methods establishing evidence-based through prospective studies.

Язык: Английский

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Heightened inflammation and immune impairments in those living with obesity may be worsened by coexistence of type 2 diabetes

American Journal of Clinical Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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How Increasing Adiposity Impacts Communicable Disease Risk at a Global and a Cellular Level

IntechOpen eBooks, Год журнала: 2025, Номер unknown

Опубликована: Апрель 19, 2025

Obesity is associated with an increased risk of a wide range morbidities. A major mechanism for this dysfunction the immune system. Immune obesity resulting number both communicable and non-communicable diseases. Non-communicable diseases such as type 2 diabetes mellitus (T2DM) make up majority share research discourse in relation to obesity. However, some infections are found result disease severity higher mortality people This was evident concerning trend during severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic. Additionally, vaccines have been induce little half protection from compared without In chapter we discuss impact infection its on vaccination—two key considerations that together contribute vulnerability obesity, public health more generally. We mechanisms dysregulation cells Understanding these dysfunctions crucial timely rates continue increase worldwide. Over billion worldwide now living individual population-level risk.

Язык: Английский

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Obesity-compromised immunity in post-COVID-19 condition: a critical control point of chronicity

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Авг. 12, 2024

Post-COVID-19 condition is recognized as a multifactorial disorder, with persistent presence of viral antigens, discordant immunity, delayed clearance, and chronic inflammation. Obesity has emerged an independent risk factor for both SARS-CoV-2 infection its subsequent sequelae. In this study, we aimed to predict the molecular mechanisms linking obesity post-COVID-19 distress. Viral antigen-exposed adipose tissues display remarkable levels receptors, facilitating entry, deposition, release inflammatory mediators cells in patients. Subsequently, obesity-associated insults are predicted disturb cellular humoral immunity by triggering abnormal cell differentiation lymphocyte exhaustion. particular, decline antibody titers T-cell exhaustion due inflammation may account virus clearance activation responses. Taken together, defective critical control point intervention against progression, particularly subjects metabolic

Язык: Английский

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