Exploring Prognostic Markers for Patients With COVID‐19 in a Low‐Resource Setting: A Cross‐Sectional Study

International Journal of Clinical Practice, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Aim: Triaging patients based on prognostic biomarkers may contribute to better management of at‐risk in resource‐constrained settings. This study aimed explore readily available and cost‐effective predictors mortality among COVID‐19 patients. Methods: cross‐sectional study, conducted across multiple centers, involved with admitted four hospitals Bangladesh. The analysis encompassed demographic information, clinical features, laboratory findings, in‐hospital outcomes. Logistic regression was utilized identify factors contributing risk. Results: Among 442 patients, 55 (12.44%) experienced mortality. patients’ mean 60 ± 14 years. DM (76% vs. 62%), IHD (42% 19%), CKD (35% 15%), COPD (24% 11%) were the most prevalent comorbidities nonsurvivors. Compared survivor group, median NLR (7 4.1; p = 0.005), ferritin (507 328; 0.21), D‐dimer (900 567; 0.12) higher nonsurvivor group. Higher age (OR 1.05; 95% CI 1.02–1.08), coexisting 2.59; 1.27–5.29), leukocytosis 2.52; 1.21–5.28), thrombocytopenia 0.27; 0.12–0.61), lower SpO2 upon admission 0.92; 0.89–0.95), more extensive lung involvement CT 1.01; 1.001–1.03) significant risk death.

Язык: Английский

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Predictors of the severity of the course of COVID-19: demographic factors, clinical signs and laboratory markers

Journal of Medical Microbiology, Год журнала: 2024, Номер 73(10)

Опубликована: Окт. 10, 2024

The Coronavirus Disease 2019 (COVID-19) pandemic has had a significant impact on global healthcare, with high mortality and severe complications remaining major concern. Understanding the predictors of COVID-19 severity may improve patient management outcomes. While considerable research focused pathogenesis virus vaccine development, identification reliable demographic, clinical laboratory disease remains critical.

Язык: Английский

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Effectiveness of bivalent mRNA booster vaccination and previous infection in older adults during Omicron period: real-world evidence

Age and Ageing, Год журнала: 2024, Номер 53(11)

Опубликована: Ноя. 1, 2024

Abstract Background The effectiveness of booster bivalent vaccines against the Omicron variant, particularly amongst older patients, remains uncertain. Objective We sought to compare relative a fourth dose vaccine using messenger ribonucleic acid (mRNA), by comparing patients who had and not received this dose. Methods conducted matched retrospective cohort study assess risk COVID-19 infection, hospitalization death people aged >60 years with four doses as compared those only three doses. Cox proportional hazard regression models were used estimate adjusted ratios (HRs) 95% confidence intervals (CIs). age, sex, nursing-home, comorbidities, primary care setting previous episodes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. also investigated impact prior SARS-CoV-2 infection within each cohort, same methodology. Results administration mRNA conferred significant additional protection (HR: 0.479; CI: 0.454–0.506), 0.393; 0.348–0.443) 30-day mortality 0.234; 0.171–0.318), individuals third monovalent In both cohorts, history involves lower COVID-infection, death. Conclusions During period predominance, receiving dose, vaccine, provides extra mortality. Antecedents vaccination notable reduction in above outcomes.

Язык: Английский

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Subcutaneous adipose tissue measured by computed tomography could be an independent predictor for early outcomes of patients with severe COVID-19

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Окт. 14, 2024

Background Patients with severe Coronavirus Disease 2019 (COVID-19) can experience protein loss due to the inflammatory response and energy consumption, impairing immune function. The presence of excessive visceral heart fat leads chronic long-term inflammation that adversely affect function and, thus, outcomes for these patients. We aimed explore roles prognostic nutrition index (PNI) quantitative assessment based on computed tomography (CT) scans in predicting patients COVID-19. Methods A total 130 COVID-19 who were treated between December 1, 2022, February 28, 2023, retrospectively enrolled. divided into survival death groups. Data chest CT examinations following admission collected measure cardiac adipose tissue (CAT), (VAT), subcutaneous (SAT) analyze score pulmonary lesions. Clinical information laboratory examination data collected. Univariate multivariate logistic regression analyses used risk factors associated death, several models established. Results Of included study (median age, 80.5 years; males, 32%), 68 died 62 survived. PNI showed a strong association outcome ( p < 0.001). Among each part volume obtained scan, SAT significant mortality = 0.007). However, VAT CAT not significantly correlated In models, had higher predictive value than PNI; area under curve (AUC) was 0.844, which (AUC 0.833), but model combination two indexes, prediction did improve 0.830), lost its significance 0.069). Conclusion Subcutaneous measured by found be independent predictors

Язык: Английский

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Probiotics and Prebiotics Intervention in Respiratory and Digestive Infections Linked to Covid-19

Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 30, 2024

Язык: Английский

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