Cited by Treatment With AC Pulsed Electromagnetic Fields Prevents Seasonal Exacerbation of Symptoms in Multiple Sclerosis

Treatment With AC Pulsed Electromagnetic Fields Prevents Seasonal Exacerbation of Symptoms in Multiple Sclerosis DOI

International Journal of Neuroscience, Год журнала: 1998, Номер 96(1-2), С. 53 - 62

Опубликована: Янв. 1, 1998

Seasonal variation in symptoms of multiple sclerosis (MS) has been well documented the literature and points to influence environmental factors on pathogenesis disease. The majority these studies indicate an increased rate exacerbation during spring and/or autumn both which are associated with desynchronization circadian pineal melatonin secretion nadirs plasma levels. Three MS patients who experienced annually recurrent incapacitating seasonal exacerbations existing presented. first patient, a 49 year old woman, developed over past 6 years lasted for about month. second 53 7 through January following year. third 42 15 years. In patients, intermittent transcranial treatments AC pulsed electromagnetic fields (EMFs) 7.5 picotesla flux density produced significant decrease motor disability additionally prevented symptoms. Since gland functions as neuroendocrine transducer immunoregulator, it is believed that decline levels facilitated magneto-sensor organ applications EMFs may have synchronized rhythms thus

Язык: Английский

Seasonal patterns in optic neuritis and multiple sclerosis: a meta-analysis DOI

Ya-Ping Jin,

Jesús de Pedro‐Cuesta,

M. Söderström

и другие.

Journal of the Neurological Sciences, Год журнала: 2000, Номер 181(1-2), С. 56 - 64

Опубликована: Дек. 1, 2000

Язык: Английский

Процитировано

Nocturnal Plasma Melatonin and Alpha-Melanocyte Stimulating Hormone Levels During Exacerbation of Multiple Sclerosis DOI

Reuven Sandyk,

Gavin I. Awerbuch

International Journal of Neuroscience, Год журнала: 1992, Номер 67(1-4), С. 173 - 186

Опубликована: Янв. 1, 1992

AbstractThe pineal gland has been implicated recently in the pathogenesis of multiple sclerosis (MS). To investigate this hypothesis further, we studied nocturnal plasma melatonin levels and presence or absence calcification (PC) on CT scan a cohort 25 patients (5 men, 20 women; mean age: 41.1 years; SD = 11.1; range: 27–72) who were admitted to hospital Neurology service for exacerbation symptoms. Plasma alpha-melanocyte stimulating hormone (alpha-MSH) estimations included study since there is evidence feedback inhibition between alpha-MSH secretion. Abnormal found 13 (52.0%), 11 whom had which below daytime values (i.e., < pg/ml). Although unrelated patient's age sex, was positive correlation with onset symptoms (p <. 0001) an inverse duration illness <.05). PC noted 24 (96%) underscoring pathogenetic relationship MS gland. Alpha-MSH undetectable 15 (60.0%), low two (8.0%), normal seven (28.0%), elevated one patient (4.0%). Collectively, abnormal over 70% patients. These findings support that may be associated failure suggest, furthermore, alterations secretion also occur during The relevance these are discussed.Key Words: Multiple sclerosispineal glandmelatoninalpha-MSH

Язык: Английский

Процитировано

Multiple Sclerosis: The Role of Puberty and the Pineal Gland in its Pathogenesis DOI

Reuven Sandyk

International Journal of Neuroscience, Год журнала: 1993, Номер 68(3-4), С. 209 - 225

Опубликована: Янв. 1, 1993

Epidemiological studies demonstrate that the incidence of multiple sclerosis (MS) is age-dependent being rare prior to age 10, unusual 15, with a peak in mid 20s. It has been suggested manifestation MS dependent upon having passed through pubertal period. In present communication, I propose critical changes pineal melatonin secretion, which occur temporal relationship onset puberty, are intimately related timing clinical manifestations MS. Specifically, it fall secretion during prepubertal period, may disrupt pineal-mediated immunomodulation, stimulate either reactivation infective agent or increase susceptibility infection Similarly, rapid just delivery account for frequent Occurrence relapse patients postpartum contrast, pregnancy, associated high concentrations, often accompanied by remission symptoms. Thus, presence levels provide protective effect, while decline risk development and exacerbation disease. The hypothesis explain other epidemiological phenomena disease such as low black African American populations, inverse correlation sun light geomagnetic field exposure, occurrence relapses relation seasonal fluctuations mood, association affective illness malignant Therapeutically, this implies application bright therapy use major synchronizers circadian rhythms sleep deprivation external weak magnetic fields be beneficial treatment and/or prophylaxis

Язык: Английский

Процитировано

The Pineal Gland and Multiple Sclerosis DOI