Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 5, 2024
Sepsis-induced
acute
lung
injury
(ALI)
is
a
major
cause
of
death
among
patients
with
sepsis
in
intensive
care
units.
By
analyzing
model
sepsis-induced
ALI
using
lipopolysaccharide
(LPS)
and
cecal
ligation
puncture
(CLP),
treatment
methods
strategies
to
protect
against
were
discussed,
which
could
provide
an
experimental
basis
for
the
clinical
ALI.
Recent
studies
have
found
that
imbalance
autophagy,
ferroptosis,
pyroptosis
key
mechanism
triggers
ALI,
regulating
these
mechanisms
can
improve
injuries
caused
by
LPS
or
CLP.
This
article
summarized
reviewed
regulatory
networks
their
important
roles
process
LPS/CLP-induced
sepsis,
discusses
possible
targeted
drugs
above
effects,
describes
dilemma
prospects,
provides
new
perspectives
future
Korean Circulation Journal,
Год журнала:
2023,
Номер
53(3), С. 151 - 151
Опубликована: Янв. 1, 2023
Acute
myocardial
infarction
(AMI)
often
occurs
suddenly
and
leads
to
fatal
consequences.
Ferroptosis
is
closely
related
the
progression
of
AMI.
However,
specific
mechanism
ferroptosis
in
AMI
remains
unclear.We
constructed
a
cell
model
using
AC16
cells
under
oxygen
glucose
deprivation
(OGD)
conditions
mice
left
anterior
descending
(LAD)
ligation.
The
3-(4,
5-dimethylthiazol-2-yl)-2,
5
diphenyltetrazolium
bromide
was
employed
determine
viability.
levels
lactate
dehydrogenase,
creatine
kinase,
reactive
species
(ROS),
glutathione
(GSH),
malondialdehyde
(MDA),
iron
were
measured
corresponding
kits.
Dual
luciferase
reporter
gene
assay,
RNA-binding
protein
immunoprecipitation,
RNA
pull-down
performed
validate
correlations
among
AC005332.7,
miR-331-3p,
cyclin
D2
(CCND2).
Hematoxylin
eosin
staining
evaluate
damage.AC005332.7
CCND2
lowly
expressed,
while
miR-331-3p
highly
expressed
vivo
vitro
models
AC005332.7
sufficiency
reduced
ROS,
MDA,
iron,
ACSL4
boosting
GSH
GPX4,
indicating
that
impeded
improve
cardiomyocyte
injury
Mechanistically,
interacted
with
targeted
CCND2.
Additionally,
overexpression
or
depletion
abolished
suppressive
impact
on
OGD-induced
cells.
Moreover,
suppressed
AMI.AC005332.7
LAD
ligation-operated
through
modulating
miR-331-3p/CCND2
axis,
thereby
mitigating
AMI,
which
proposed
novel
targets
for
treatment.
Cell Cycle,
Год журнала:
2023,
Номер
22(9), С. 1062 - 1073
Опубликована: Янв. 26, 2023
In
recent
years,
researchers
have
begun
to
realize
the
importance
of
role
non-coding
RNAs
in
treatment
cancer
and
cardiovascular
neurological
diseases.
LncRNAs
miRNAs
are
important
RNAs,
which
regulate
gene
expression
activate
mRNA
translation
through
binding
diverse
target
sites.
Their
involvement
regulation
protein
function
modulation
physiological
pathological
conditions
continues
be
investigated.
Sirtuins,
especially
Sirt1,
a
critical
regulating
variety
processes
such
as
oxidative
stress,
inflammation,
apoptosis,
autophagy.
The
lncRNAs/miRNAs/Sirt1
axis
may
novel
regulatory
mechanism,
is
involved
progression
and/or
prevention
numerous
This
review
focuses
on
findings
crosstalk
between
Sirt1
myocardial
cerebral
injuries
provide
some
insight
into
development
approaches
these
disorders.
Journal of Diabetes Investigation,
Год журнала:
2023,
Номер
14(9), С. 1056 - 1069
Опубликована: Июнь 14, 2023
Hyperglycemia
accelerates
the
development
of
diabetic
nephropathy
(DN)
by
inducing
renal
tubular
injury.
Nevertheless,
mechanism
has
not
been
elaborated
fully.
Here,
pathogenesis
DN
was
investigated
to
seek
novel
treatment
strategies.A
model
established
in
vivo,
levels
blood
glucose,
urine
albumin
creatinine
ratio
(ACR),
creatinine,
urea
nitrogen
(BUN),
malondialdehyde
(MDA),
glutathione
(GSH),
and
iron
were
measured.
The
expression
detected
qRT-PCR
Western
blotting.
H&E,
Masson,
PAS
staining
used
assess
kidney
tissue
mitochondria
morphology
observed
transmission
electron
microscopy
(TEM).
molecular
interaction
analyzed
using
a
dual
luciferase
reporter
assay.SNHG1
ACSL4
increased
tissues
mice,
but
miR-16-5p
decreased.
Ferrostatin-1
or
SNHG1
knockdown
inhibited
ferroptosis
high
glucose
(HG)-treated
HK-2
cells
db/db
mice.
Subsequently,
confirmed
be
target
for
SNHG1,
directly
targeted
ACSL4.
Overexpression
greatly
reversed
protective
roles
HG-induced
cells.SNHG1
via
miR-16-5p/ACSL4
axis
alleviate
nephropathy,
which
provided
some
new
insights
nephropathy.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 5, 2024
Sepsis-induced
acute
lung
injury
(ALI)
is
a
major
cause
of
death
among
patients
with
sepsis
in
intensive
care
units.
By
analyzing
model
sepsis-induced
ALI
using
lipopolysaccharide
(LPS)
and
cecal
ligation
puncture
(CLP),
treatment
methods
strategies
to
protect
against
were
discussed,
which
could
provide
an
experimental
basis
for
the
clinical
ALI.
Recent
studies
have
found
that
imbalance
autophagy,
ferroptosis,
pyroptosis
key
mechanism
triggers
ALI,
regulating
these
mechanisms
can
improve
injuries
caused
by
LPS
or
CLP.
This
article
summarized
reviewed
regulatory
networks
their
important
roles
process
LPS/CLP-induced
sepsis,
discusses
possible
targeted
drugs
above
effects,
describes
dilemma
prospects,
provides
new
perspectives
future
