The Causal Relationships and Therapeutic Targets of Plasma Proteins in Ankylosing Spondylitis

Biomedicines, Год журнала: 2025, Номер 13(2), С. 306 - 306

Опубликована: Янв. 27, 2025

Objective: The purpose of this study was to assess the causal effects circulating plasma proteins on ankylosing spondylitis (AS) and explore potential therapeutic targets. Methods: used protein quantitative trait loci (pQTLs) for thousands from nine genome-wide association studies (GWAS) as instrumental variables. relationship between genetically predicted AS assessed through Mendelian randomization (MR) analysis. Further analyses, including colocalization analysis, Steiger filtering protein-altering variant assessment, protein–protein interaction (PPI), pathway enrichment were conducted validate robustness direction results, well investigate functions drug Results: Nine unique found have strong associations with AS. analysis confirmed that all identified by MR a direct link Colocalization four proteins—Interleukin-6 receptor alpha (IL-6Rα), Interleukin-23 (IL-23R), Thrombospondin-2 (THBS2), Interleukin-1 type 2 (IL-1R2)—that share same variants PPI revealed roles these in inflammatory responses immune regulation. Moreover, valuable targets or considered druggable. Conclusions: This has multiple associated AS, revealing important pathogenesis providing

Язык: Английский

Receptor-Interacting Protein Kinase 3 as a Serological Biomarker in Relation to Disease Severity and Delirium After Acute Pancreatitis: A Prospective Cohort Study

International Journal of General Medicine, Год журнала: 2024, Номер Volume 17, С. 5309 - 5323

Опубликована: Ноя. 1, 2024

Delirium is a common complication of acute pancreatitis. Receptor-interacting protein kinase 3 (RIP3) an activator programmed cell necrosis. This study aimed to determine its ability predict delirium after

Язык: Английский