Engineering organoids as cerebral disease models
Current Opinion in Biotechnology,
Год журнала:
2025,
Номер
92, С. 103253 - 103253
Опубликована: Янв. 14, 2025
Cerebral
organoids
pioneered
in
replicating
complex
brain
tissue
architectures
vitro,
offering
a
vast
potential
for
human
disease
modeling.
They
enable
the
vitro
study
of
physiological
and
pathophysiological
mechanisms
various
neurological
diseases
disorders.
The
trajectory
technological
advancements
organoid
generation
engineering
over
past
decade
indicates
that
technology
might,
future,
mature
into
indispensable
solutions
at
horizon
personalized
regenerative
medicine.
In
this
review,
we
highlight
recent
advances
as
models
discuss
some
challenges
opportunities
future
research
rapidly
evolving
field.
Язык: Английский
Brain organoids: A new tool for modelling of neurodevelopmental disorders
Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(17)
Опубликована: Сен. 1, 2024
Abstract
Neurodevelopmental
disorders
are
mostly
studied
using
mice
as
models.
However,
the
mouse
brain
lacks
similar
cell
types
and
structures
those
of
human
brain.
In
recent
years,
emergence
three‐dimensional
organoids
derived
from
embryonic
stem
cells
or
induced
pluripotent
allows
for
controlled
monitoring
evaluation
early
neurodevelopmental
processes
has
opened
a
window
studying
various
aspects
development.
such
lack
original
anatomical
structure
during
maturation,
maturation
that
rely
on
unique
cellular
interactions
neural
network
connections
limited.
Consequently,
difficult
to
be
used
extensively
effectively
while
modelling
later
stages
development
disease
progression.
To
address
this
problem,
several
methods
technologies
have
emerged
aim
enhance
sophisticated
regulation
developmental
through
bioengineering
approaches,
which
may
alleviate
some
current
limitations.
This
review
discusses
advances
application
areas
organoid
culture
methods,
aiming
generalize
optimization
strategies
systems,
improve
ability
mimic
development,
value
organoids.
Язык: Английский
Assessing the Utility of Organoid Intelligence: Scientific and Ethical Perspectives
Organoids,
Год журнала:
2025,
Номер
4(2), С. 9 - 9
Опубликована: Май 1, 2025
The
development
of
brain
organoids
from
human-induced
pluripotent
stem
cells
(iPSCs)
has
expanded
research
into
neurodevelopment,
disease
modeling,
and
drug
testing.
More
recently,
the
concept
organoid
intelligence
(OI)
emerged,
proposing
that
these
constructs
could
evolve
to
support
learning,
memory,
or
even
sentience.
While
this
perspective
driven
enthusiasm
in
field
suggested
new
applications
fields
such
as
neuromorphic
computing,
it
also
introduces
significant
scientific
conceptual
concerns.
Current
lack
anatomical
complexity,
network
organization,
sensorimotor
integration
necessary
for
Despite
this,
claims
surrounding
OI
often
rely
on
oversimplified
interpretations
neural
activity,
fueled
by
neurorealist
reification
biases
misattribute
neurophysiological
properties
biologically
limited
systems.
Beyond
limitations,
framing
risks
imposing
ethical
regulatory
challenges
based
speculative
concerns
rather
than
empirical
evidence.
assumption
might
possess
sentience,
develop
over
time,
lead
unnecessary
restrictions
legitimate
while
misrepresenting
their
actual
capabilities.
Additionally,
comparing
biological
systems
silicon-based
computing
overlooks
fundamental
differences
scalability,
efficiency,
predictability,
raising
questions
about
whether
can
meaningfully
contribute
computational
advancements.
must
recognize
limitations
models
prematurely
defining
a
distinct
domain.
A
more
cautious,
evidence-driven
approach
is
ensure
remain
valuable
tools
neuroscience
without
overstating
potential.
To
maintain
credibility
public
trust,
essential
separate
narratives
grounded
research,
thus
allowing
continued
progress
studies
reinforcing
misconceptions
Язык: Английский