From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

Advanced Science, Год журнала: 2024, Номер 11(17)

Опубликована: Фев. 21, 2024

Abstract Periodontitis is a dysbiosis‐driven inflammatory disease affecting the tooth‐supporting tissues, characterized by their progressive resorption, which can ultimately lead to tooth loss. A step‐wise therapeutic approach employed for periodontitis. After an initial behavioral and non‐surgical phase, intra‐bony or furcation defects may be amenable regenerative procedures. This review discusses technologies periodontal regeneration, highlighting current limitations future research areas. The search, performed on MEDLINE database, has identified available biomaterials, including biologicals (autologous platelet concentrates, hydrogels), bone grafts (pure putty), membranes. Biologicals have been critically analyzed in terms of composition, mechanism action, clinical applications. Although certain degree regeneration predictable class II defects, complete defect closure hardly achieved. Moreover, treating III remains challenging. key properties required functional are discussed, none commercially biomaterials possess all ideal characteristics. Therefore, needed promote advancement more effective targeted therapies Lastly, improving design reporting studies suggested strictly adhering Consolidated Standards Reporting Trials (CONSORT) 2010 statement.

Язык: Английский

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Systematic review and meta-analysis on prevalence and risk factors for gingival recession

Journal of Dentistry, Год журнала: 2025, Номер unknown, С. 105645 - 105645

Опубликована: Фев. 1, 2025

Язык: Английский

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Performance of the 2017 AAP/EFP case definition compared with the CDC/AAP definition in population‐based studies

Journal of Periodontology, Год журнала: 2021, Номер 93(7), С. 1003 - 1013

Опубликована: Окт. 9, 2021

Abstract Background Classification of the periodontal conditions is indispensable for epidemiological data in order to guide situational awareness and therapeutic strategies. The new classification diseases introduced by American Academy Periodontology European Federation (AAP/EFP), however, has not yet been applied population‐based studies. aim present study was compare prevalence periodontitis between AAP/EFP CDC/AAP system evaluate accuracy against case definition Methods Epidemiological from two cross‐sectional studies were obtained. One them a on Chilean adults (1.456 individuals; 35–44 years; 65–74 years) other one sample adolescents (1.070 15–19 five countries; Argentina, Chile, Colombia, Ecuador, Uruguay. All participants had undergone full‐mouth examination calibrated examiners. datasets analyzed according definitions. examined assessing sensitivity, specificity, positive predictive value (PPV), negative (NPV), area under receiver operating curve (ROC) using as reference standard. Results According AAP/EFP, 75.6%. majority classified either Stage I (39.2%) or II (28.2%). By 27.2%. most common form with moderate (15.3%) followed mild (11.4%). revealed high sensitivity (95.7%) severe (100%) well (75%) specificity (92%) periodontitis, respectively. PPV 41.6% 5.7% whereas NPV both categories (moderate = 99%; 100%). AUC 0.91 (95% CI 0.89–0.93). In adults, 99% AAP/EFP. IV (81.3%) III amounted 12.8%. classification, 88.3% (57.2%) (29.7%). (99.7%) (100%), but low 6.8%; 8.3%). 88.7% 31.7% periodontitis. 76.5%; 0.57 0.53–0.62). Conclusions This clear discrepancy when data. 2017 performs compared identifying seems less accurate

Язык: Английский

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Global prevalence of gingival recession: A systematic review and meta‐analysis

Oral Diseases, Год журнала: 2022, Номер 29(8), С. 2993 - 3002

Опубликована: Июнь 23, 2022

Abstract Objective This systematic review and meta‐analysis aimed to estimate the global prevalence of gingival recession (GR) in general population. Materials Methods Population‐based observational studies reporting GR published from 1991 2021 were identified five electronic databases manual searches. Risk bias was assessed using Joanna Briggs Institute's Critical Appraisal Checklist for Prevalence Studies. The pooled calculated by a random‐effect model. Grading Recommendations, Assessment, Development Evaluation (GRADE) approach used summarize overall certainty evidence. Results A total 15 involving 37,460 participants included. 78.16% at minimal reported threshold values 84.92% ≥1 mm “cut‐off” with high heterogeneity among studies. separate analysis buccal revealed 75.42%. risk found be 10 low 5 evidence very low. Conclusion More than two‐thirds population worldwide affected GR. Studies standard case definition less are required accurately

Язык: Английский

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Annual Incidence and Pre‐Treatment Prognostic Factors of Labial Gingival Recessions in Young Orthodontically Treated Patients

Journal of Periodontal Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Gingival recession occurrence is highly prevalent after orthodontic treatment, and keeratinised tissue width at baseline significantly correlated with the prevalence, extension, severity of gingival recession, clearly demonstrating importance evaluating periodontal factors in planning treatment.

Язык: Английский

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Prevalence and risk/protective indicators of buccal soft tissue dehiscence around dental implants

Journal Of Clinical Periodontology, Год журнала: 2020, Номер 48(3), С. 455 - 463

Опубликована: Дек. 30, 2020

To evaluate the prevalence of buccal peri-implant soft tissue dehiscence (PISTD) in anterior implants and to identify risk/protective indicators PISTD not suffering peri-implantitis.240 randomly selected patients from a university clinic database were invited participate present cross-sectional study. Those who accepted, after evaluation their medical dental records, clinically examined assess non-molar implants. Multilevel multivariate logistic regression analyses then carried out those factors associated either positively (risk) or negatively (protective) with without peri-implantitis.92 total 272 analysed. At implant-level, was 16.9%, while when selecting only peri-implantitis it 12.0%. Buccal 26.7% diagnosed peri-implantitis. The following identified as peri-implantitis: malposition (too vs. correct: OR=14.67), thin phenotype (OR=8.31), presence at least one adjacent tooth (OR=0.08) abutment (OR=0.12).PISTD are highly prevalent among this university-based population, several risk protective

Язык: Английский

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Platelet-Rich Fibrin in Single and Multiple Coronally Advanced Flap for Type 1 Recession: An Updated Systematic Review and Meta-Analysis

Medicina, Год журнала: 2021, Номер 57(2), С. 144 - 144

Опубликована: Фев. 5, 2021

Background and Objectives: The aim of the present systematic review meta-analysis was to investigate efficacy leukocyte–platelet-rich fibrin (L-PRF) in addition coronally advanced flap (CAF) for treatment both single multiple gingival recessions (GRs) compared CAF alone adjunct connective tissue graft (CTG). Root coverage outcomes using platelet concentrates have gained increased interest. In particular, it has been suggested that adding L-PRF may provide further benefits GRs. Materials Methods: An electronic manual literature search conducted identify randomized controlled trials (RTCs) investigating root with + L-PRF. interest included mean (mRC), recession reduction, keratinized width (KTW) gain, thickness (GT) patient-reported outcome measures (PROms) such as pain perception discomfort. Results: A total 275 patients 611 surgical sites were analyzed. seems show statistically significant results regarding clinical attachment level (CAL) a weighted means (WM) 0.43 95% CI (−0.04, 0.91), p < 0.0001, GT (WM 0.17 (−0.02, 0.36), mRC 13.95 (−1.99, 29.88) alone. Interesting obtained from PRF respect an increase WM 0.07 (−30.22, 30.35), = PPD change 0.26 (−0.06, 0.58), 00001. On other hand, no data when added or combined CTG according (p 0.03 overall). Conclusions: is valid alternative showed discomfort PROms 0.0001). However, remains gold standard treating recession.

Язык: Английский

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Recombinant human platelet‐derived growth factor improves root coverage of a collagen matrix for multiple adjacent gingival recessions: A triple‐blinded, randomized, placebo‐controlled trial

Journal Of Clinical Periodontology, Год журнала: 2022, Номер 49(11), С. 1169 - 1184

Опубликована: Июль 25, 2022

To evaluate the efficacy of recombinant human platelet-derived growth factor (rhPDGF)-BB combined with a cross-linked collagen matrix (CCM) for treatment multiple adjacent gingival recession type 1 defects (MAGRs) in combination coronally advanced flap (CAF).Thirty patients were enrolled this triple-blind, randomized, placebo-controlled trial and treated either CAF + CCM rhPDGF, or saline. The primary outcome was mean root coverage (mRC) at 6 months. Complete coverage, gain thickness (GT), keratinized tissue width, volumetric ultrasonographic changes, patient-reported measures also assessed. Mixed-modelling regression analyses used statistical comparisons.At months, mRC rhPDGF alone groups 88.25% 77.72%, respectively (p = .02). A significant GT consistently observed both arms, more so receiving containing through time (0.51 vs. 0.80 mm, on average, p .01). presented greater volume gain, higher soft thickness, superior aesthetic score.rhPDGF enhances clinical, volumetric, outcomes MAGRs above results achieved (ClinicalTrials.gov NCT04462237).

Язык: Английский

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Are periodontitis and dental caries associated? A systematic review with meta‐analyses

Journal Of Clinical Periodontology, Год журнала: 2023, Номер 51(2), С. 145 - 157

Опубликована: Дек. 12, 2023

The epidemiological relationship between periodontitis and caries remains controversial, evidence synthesis is currently lacking. Therefore, this systematic review was designed to answer the following PECO question: 'In human adults (P), do subjects suffering from (E) have higher presence/number of untreated carious lesions experience (O) than not (C)?'.

Язык: Английский

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Tunnel vs. coronally advanced flap in combination with a connective tissue graft for the treatment of multiple gingival recessions: a multi-center randomized clinical trial

Clinical Oral Investigations, Год журнала: 2023, Номер 27(7), С. 3627 - 3638

Опубликована: Март 29, 2023

Abstract Objective To evaluate the efficacy of partial-thickness non-advanced tunnel technique (TUN) versus coronally advanced flap (CAF), both combined with a connective tissue graft, in treatment multiple gingival recessions. Materials and methods Twenty-nine patients (83 teeth) affected by recessions were treated two clinical centers either test or control (CAF) intervention graft. Outcomes at 3 6 months after surgery included complete root coverage (CRC—primary outcome), mean (mRC), changes recession depth (RD), probing pocket (PPD), keratinized height (KT). Root sensitivity esthetic score (RES) also evaluated 6-month examination. Surgery duration, wound healing index (WHI), patient-reported outcome measures (PROMs) additionally considered. Results At months, CRC was observed 80.9% 79.5% teeth TUN CAF, respectively (odds ratio = 1.2; p 0.802). No differences between groups terms mRC (TUN 94.0%; CAF 91.1%), RD PPD reductions, sensitivity, RES, WHI. KT increase significantly higher (Difference Means – MD − 1.0 mm; 0.001). duration shorter (MD 19.3 min; 0.001), reported less intra-surgical pain 16.4; 0.028) as well postoperative morbidity compared CAF. Conclusions Both surgical interventions showed similar coverage, albeit associated milder patient’s experience. Clinical relevance techniques have shown for exposed surfaces, although clinicians may consider invasive. Trial registration Clinicaltrials.gov (NCT05122468)

Язык: Английский

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