Dentistry Journal,
Год журнала:
2025,
Номер
13(6), С. 231 - 231
Опубликована: Май 23, 2025
Background:
Tooth
extractions
commonly
result
in
dimensional
changes
of
the
alveolar
ridge.
Platelet-rich
fibrin
(PRF)
has
emerged
as
a
promising
autologous
biomaterial
for
preservation.
This
randomized
controlled
trial
aimed
to
evaluate,
through
cone
beam
computed
tomography
(CBCT),
effect
PRF
maintaining
dimensions
post-extraction.
Methods:
A
single-blind,
clinical
was
conducted
10
systemically
healthy
patients
requiring
premolar
orthodontic
reasons.
total
36
alveoli
were
analyzed:
19
with
(experimental
group)
and
17
without
(control
group).
CBCT
scans
performed
at
baseline,
30
days,
120
days
post-extraction
measure
height,
vestibulo-palatal/lingual
depth
1,
3,
5
mm,
bone
tissue
density
using
Hounsfield
Units
(HU).
Results:
Baseline
cephalocaudal
height
similar
both
groups
(~10.5
p
=
0.399).
At
preservation
significantly
greater
group
(10.61
mm
vs.
8.82
<
0.001).
maintained
(10.30
9.31
mm),
although
this
difference
not
statistically
significant
(p
0.059).
No
differences
observed
or
>
0.05).
The
showed
trend
toward
better
higher
mean
values
(190–282
HU),
no
formal
statistical
comparison
HU
performed.
Repeated
measures
ANOVA
revealed
interaction
time
on
0.010,
η2
0.046)
1
0.035,
0.020).
Conclusions:
improved
short-term
Trends
group,
these
findings
significant.
appears
be
safe
potential
support
ridge
maintenance
Dentistry Journal,
Год журнала:
2023,
Номер
11(8), С. 196 - 196
Опубликована: Авг. 14, 2023
After
tooth
extraction,
the
alveolar
ridge
undergoes
a
physiological
process
of
remodelling
and
disuse
atrophy.
Socket
augmentation
(SA)
has
been
shown
to
preserve
bone
volume
in
order
facilitate
implant
placement
reduce
need
for
staged
grafting
at
later
date.
Although
autogenic
be
gold
standard
regeneration,
it
significant
disadvantages.
To
prevent
post-extraction
volumetric
alterations
resorption
occurring,
alternative
materials,
including
xenografts,
alloplasts,
allografts,
have
used
successfully
fresh
extraction
sites.
However,
these
materials
act
mostly
as
bio-scaffolds
require
slower
integration
period
6–8
months
prior
placement.
Recently,
use
autologous
platelet-rich
fibrin
(PRF)
advocated
alongside
socket
method
bio-enhancement
healing
soft
hard
tissues.
PRF
contains
platelet-derived
growth
factors,
hormones,
bioactive
components
such
cytokines
that
promote
angiogenesis
tissue
regeneration
during
wound
healing.
The
aim
this
article
is
review
evidence
base
SA
technique
Clinical
benefits
will
discussed
with
reference
two
cases.
Therefore,
narrative
discuss
changes,
importance
SA,
role
management
site
defects
when
immediate
not
possible
or
contraindicated.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(12), С. 377 - 377
Опубликована: Дек. 14, 2024
Background:
Advanced
platelet-rich
fibrin
(A-PRF)
is
produced
by
centrifuging
the
patient’s
blood
in
vacuum
tubes
for
14
min
at
1500
rpm.
The
most
important
component
of
A-PRF
platelets,
which
release
growth
factors
from
their
⍺-granules
during
clotting
process.
This
process
believed
to
be
main
source
factors.
aim
this
paper
was
systematically
review
literature
and
summarize
role
oral
maxillo-facial
surgery.
Materials
Methods:
A
systematic
carried
out,
following
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
(PRISMA)
guidelines
(PROSPERO:
CRD42024584161).
Results:
Thirty-eight
articles
published
before
11
November
2024
were
included
review.
largest
study
group
consisted
102
patients,
smallest
10
patients.
often
analyzed
compared
leukocyte-PRF
(L-PRF)
or
cloth.
correlated
with
lower
postoperative
pain.
Also,
highlighted
have
a
positive
effect
on
grafting
material
integration.
protected
areas
after
free
gingival
graft
very
well,
promoted
more
efficient
epithelialization
donor
sites
enhanced
wound
healing.
Conclusions:
Due
its
biological
properties,
could
considered
reliable
addition
surgical
protocols,
both
alone
as
an
additive
bio-materials,
advantages
healing
improvement,
pain
relief,
soft
tissue
management
bone
preservation,
well
However,
determine
long-term
clinical
implications
recommendations
practice,
well-designed
randomized
trials
are
needed
each
application,
especially
those
larger
patient
cohorts,
additional
blinding
personnel
long
follow-up
periods.
Dentistry Journal,
Год журнала:
2022,
Номер
10(2), С. 29 - 29
Опубликована: Фев. 16, 2022
The
maintenance
of
ridge
volume
following
tooth
extraction
has
gained
more
importance
in
the
last
few
years.
This
clinical
study
aimed
to
assess
impact
autologous
dentin
particles
mixed
with
injectable
platelet-rich
fibrin
(i-PRF)
on
a
sticky
mixture
for
socket
preservation
terms
consecutive
need
horizontal
guided
bone
regeneration
and
histological
findings.Eight
sockets
seven
patients
were
included
this
study.
Autologous
PRF,
filled
sockets,
covered
cross-linked
collagen
membrane
exposed
oral
cavity
fixated
by
crisscross
sutures.
An
orthopantomogram
was
taken
before
first
surgical
procedure
CBCT
prior
static
computer-aided
implant
surgery.
At
time
placement,
cores
harvested
aid
trephine
examinations
every
preserved
socket.No
further
GBR
intervention
required
any
cases,
findings
unremarkable.
new
mostly
cancellous
direct
contact
remaining
granules.Within
limits
study,
it
may
be
concluded
that
method
is
valuable
obtaining
vital
good
quality
structure.
technique
seems
very
efficient
despite
complex
equipment.
Journal Of Clinical Periodontology,
Год журнала:
2022,
Номер
50(S25), С. 67 - 82
Опубликована: Июль 11, 2022
Abstract
Aim
To
evaluate
outcome
measures
and
methods
of
assessment
in
clinical
studies
on
bone
augmentation/preservation
procedures
for
the
placement
dental
implants.
Materials
Methods
A
systematic
search
was
performed
three
databases
from
January
2011
to
April
2021
identify
reporting
any
type
procedure.
The
outcomes
that
have
been
used
assess
efficacy
or
performance
each
study
were
registered
assigned
different
domains
(group
outcomes).
review
followed
Preferred
Reporting
Items
Systematic
Review
Meta‐Analyses
statement.
Results
Seven‐hundred
eighty‐three
publications
included.
Only
81.8%
papers
had
a
clear
definition
their
primary
outcome.
rate
complications
(59.3%),
implant
survival
(58.2%),
3D
radiographic
gain/change
(30%),
marginal
level
(MBL;
29%),
histological
(25.5%)
most
frequently
reported
domains.
commonly
(25.8%),
by
(13.0%).
Patient‐reported
(PROMs)
15.7%
studies.
Differences
observed
among
types
preservation/augmentation
interventions
(i.e.,
alveolar
ridge
preservation,
immediate
implants,
horizontal
and/or
vertical
augmentation,
sinus
floor
augmentation).
Conclusion
Within
past
decade,
great
heterogeneity
considered
evaluating
procedures.
Three‐dimensional
routinely
main
variable,
while
PROMs
rarely
reported.
Dentistry Journal,
Год журнала:
2023,
Номер
11(10), С. 244 - 244
Опубликована: Окт. 23, 2023
In
dental
implantology,
alveolar
ridge
preservation
(ARP)
has
emerged
as
a
standard
technique
to
address
dimensional
changes
that
affect
morphology
following
tooth
loss.
Various
alternative
graft
materials,
including
xenografts,
alloplasts,
and
allografts,
have
been
effectively
employed
in
fresh
extraction
sites
for
ARP.
Current
evidence
suggests
these
materials
primarily
serve
bio-scaffolds,
which
are
slowly
incorporated,
thus
necessitating
waiting
period
of
at
least
4–6
months
before
implant
placement.
Consequently,
the
ARP
extends
overall
duration
treatment
by
several
months.
Recently,
incorporation
form
autologous
platelet
concentrate,
known
platelet-rich
fibrin
(PRF),
advocated
conjunction
with
method
bioenhancement
soft-
hard-tissue
healing
regeneration.
PRF
contains
platelet-derived
growth
factors,
hormones,
bioactive
components
like
cytokines
demonstrated
ability
stimulate
angiogenesis
tissue
regeneration
throughout
all
phases
wound
healing.
Additionally,
concentration
leukocytes
present
matrix
plays
vital
role
part
osteoimmune
response.
The
reported
advantages
incorporating
autogenous
concentrates
during
encompass
reduced
time,
improved
bone
regeneration,
socket
sealing
through
matrix,
antibacterial
properties,
decreased
post-extraction
pain
infection
risk.
Therefore,
objective
this
paper
is
review
existing
regarding
application
extraction.
Two
clinical
case
studies
presented,
wherein
was
enhanced
PRF,
followed
placement
within
relatively
short
8
weeks.
These
cases
further
proof
concept
supporting
adjuvant
use
enhance
accelerate
after
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
168, С. 115795 - 115795
Опубликована: Ноя. 2, 2023
Platelet-rich
fibrin
(PRF),
as
an
autologous
blood
preparation,
has
been
receiving
increasing
attention
in
recent
years
and
successfully
applied
various
clinical
treatments
for
alveolar
bone
regeneration
the
oral
field.
This
review
focuses
on
analyzing
summarizing
role
mechanism
of
PRF
regeneration.
We
first
provide
a
brief
introduction
to
PRF,
then
summarize
mechanisms
by
which
promotes
from
three
aspects:
osteogenesis
mechanism,
induction
conduction
involving
multiple
signaling
pathways
such
Smad,
ERK1/2,
PI3K/Akt,
Wnt/β-catenin.
also
explore
roles
scaffold,
filler,
combination
with
graft
materials,
detailing
how
provides
wealth
experimental
evidence.
Finally,
we
current
applications
fields.
The
is
becoming
increasingly
important,
its
are
more
research
understanding.
article
will
reference
significant
value
related
exploration
may
lead
discovery
new
therapeutic
targets
development
effective
efficient
treatment
strategies.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4339 - 4339
Опубликована: Апрель 14, 2024
Chronic
odontogenic
maxillary
sinusitis
(COMS),
a
prolonged
inflammation
of
the
sinus
lasting
over
12
weeks,
is
often
result
periapical
lesions,
marginal
periodontitis,
and
complications
like
oro-antral
communication
(OAC)
fistula
(OAF).
OAC,
commonly
emerging
post-teeth
extraction
in
lateral
maxilla,
lacks
documented
treatments
using
advanced
platelet-rich
fibrin
(A-PRF).
This
study
evaluates
A-PRF's
efficacy
treating
COMS
immediately
sealing
extensive
OAC.
A
case
28-year-old
male
with
linked
to
lesion
supernumerary
molars
presented.
Treatment
involved
extracting
specific
teeth
while
preserving
adjacent
ones
A-PRF
for
immediate
OAC
closure.
A-PRF,
enriched
growth
factors,
was
pivotal
healing,
showcasing
enhanced
tissue
regeneration,
pain
reduction,
faster
recovery.
The
findings
suggest
as
an
effective
adjunct
COMS,
proposing
its
inclusion
standard
treatment
protocols.
underscores
potential
improving
outcomes
patients
related
complications.
Bioengineering,
Год журнала:
2024,
Номер
11(5), С. 414 - 414
Опубликована: Апрель 23, 2024
Platelet-rich
fibrin,
the
coagulated
plasma
fraction
of
blood,
is
commonly
used
to
support
natural
healing
in
clinical
applications.
The
rat
calvaria
defect
a
standardized
model
study
bone
regeneration.
It
remains,
however,
unclear
if
appropriate
investigate
impact
human
PRF
(Platelet-Rich
Fibrin)
on
To
this
end,
we
soaked
Bio-Gide®
collagen
membranes
or
liquid
concentrated
before
placing
them
onto
5
mm
calvarial
defects
Sprague
Dawley
rats.
Three
weeks
later,
histology
and
micro-computed
tomography
(μCT)
were
performed.
We
observed
that
with
show
characteristic
features
new
areas
mineralized
matrix,
indicated
by
median
volume
1.5
mm3
(range:
0.9;
5.3
mm3).
Histology
revealed
growing
underneath
membrane
hybrid
where
fibers
are
embedded
bone.
Moreover,
passive
mineralization
observed.
PRF,
devoid
histological
formation
center
defect;
only
occasionally,
formed
at
margins.
Human
(h-PRF)
caused
0.9
0.3-3.3
mm3),
which
was
significantly
lower
than
what
(r-PRF),
BV
1.2
0.3-5.9
Our
findings
indicate
suitable
for
assessing
effects
formation,
but
caution
warranted
when
extrapolating
conclusions
regarding
efficacy
PRF.
Bioengineering,
Год журнала:
2024,
Номер
11(6), С. 566 - 566
Опубликована: Июнь 3, 2024
Background:
Over
time,
numerous
surgical
procedures
and
biomaterials
have
been
proposed
for
the
reconstruction
of
post-extraction
bone
defects,
each
with
their
advantages
disadvantages.
The
main
objective
this
study
was
to
evaluate
dimensional
changes
in
alveolar
3
months
after
tooth
extraction,
before
implant
planning,
comparing
ridge
preservation
(ARP)
spontaneous
healing.
Methods:
A
total
84
patients
non-restorable
molars
were
included
study.
Forty-two
received
ARP
advanced
platelet-rich
fibrin
(A-PRF)
healing
evaluated
these
patients.
Cone
beam
computed
tomography
(CBCT)
analysis
performed
intervention
used
determine
vertical
horizontal
dimensions
produced
extraction.
Results:
CBCT
measurements
showed
reduction
both
size
groups.
For
group,
parameters
(height,
width)
higher
compared
control
group.
percentage
variations
between
differences
from
two
groups
38.58%
height,
width
36.88%
at
0
mm,
35.56%
36.61%
5
38.73%
7
mm.
statistically
significant
(p
˂
0.0005).
Conclusions:
results
obtained
A-PRF
a
reduced
loss
volume