Extraction Socket Augmentation with Autologous Platelet-Rich Fibrin (PRF): The Rationale for Socket Augmentation

Dentistry Journal, Год журнала: 2023, Номер 11(8), С. 196 - 196

Опубликована: Авг. 14, 2023

After tooth extraction, the alveolar ridge undergoes a physiological process of remodelling and disuse atrophy. Socket augmentation (SA) has been shown to preserve bone volume in order facilitate implant placement reduce need for staged grafting at later date. Although autogenic be gold standard regeneration, it significant disadvantages. To prevent post-extraction volumetric alterations resorption occurring, alternative materials, including xenografts, alloplasts, allografts, have used successfully fresh extraction sites. However, these materials act mostly as bio-scaffolds require slower integration period 6–8 months prior placement. Recently, use autologous platelet-rich fibrin (PRF) advocated alongside socket method bio-enhancement healing soft hard tissues. PRF contains platelet-derived growth factors, hormones, bioactive components such cytokines that promote angiogenesis tissue regeneration during wound healing. The aim this article is review evidence base SA technique Clinical benefits will discussed with reference two cases. Therefore, narrative discuss changes, importance SA, role management site defects when immediate not possible or contraindicated.

Язык: Английский

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Does the Choice of Preparation Protocol for Platelet-Rich Fibrin Have Consequences for Healing and Alveolar Ridge Preservation After Tooth Extraction? A Meta-Analysis

Journal of Oral and Maxillofacial Surgery, Год журнала: 2023, Номер 81(5), С. 602 - 621

Опубликована: Янв. 31, 2023

Язык: Английский

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Application of Advanced Platelet-Rich Fibrin in Oral and Maxillo-Facial Surgery: A Systematic Review

Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(12), С. 377 - 377

Опубликована: Дек. 14, 2024

Background: Advanced platelet-rich fibrin (A-PRF) is produced by centrifuging the patient’s blood in vacuum tubes for 14 min at 1500 rpm. The most important component of A-PRF platelets, which release growth factors from their ⍺-granules during clotting process. This process believed to be main source factors. aim this paper was systematically review literature and summarize role oral maxillo-facial surgery. Materials Methods: A systematic carried out, following Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines (PROSPERO: CRD42024584161). Results: Thirty-eight articles published before 11 November 2024 were included review. largest study group consisted 102 patients, smallest 10 patients. often analyzed compared leukocyte-PRF (L-PRF) or cloth. correlated with lower postoperative pain. Also, highlighted have a positive effect on grafting material integration. protected areas after free gingival graft very well, promoted more efficient epithelialization donor sites enhanced wound healing. Conclusions: Due its biological properties, could considered reliable addition surgical protocols, both alone as an additive bio-materials, advantages healing improvement, pain relief, soft tissue management bone preservation, well However, determine long-term clinical implications recommendations practice, well-designed randomized trials are needed each application, especially those larger patient cohorts, additional blinding personnel long follow-up periods.

Язык: Английский

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Tooth-Derived Granules in Combination with Platelet-Rich Fibrin (“Sticky Tooth”) in Socket Preservation: A Histological Evaluation

Dentistry Journal, Год журнала: 2022, Номер 10(2), С. 29 - 29

Опубликована: Фев. 16, 2022

The maintenance of ridge volume following tooth extraction has gained more importance in the last few years. This clinical study aimed to assess impact autologous dentin particles mixed with injectable platelet-rich fibrin (i-PRF) on a sticky mixture for socket preservation terms consecutive need horizontal guided bone regeneration and histological findings.Eight sockets seven patients were included this study. Autologous PRF, filled sockets, covered cross-linked collagen membrane exposed oral cavity fixated by crisscross sutures. An orthopantomogram was taken before first surgical procedure CBCT prior static computer-aided implant surgery. At time placement, cores harvested aid trephine examinations every preserved socket.No further GBR intervention required any cases, findings unremarkable. new mostly cancellous direct contact remaining granules.Within limits study, it may be concluded that method is valuable obtaining vital good quality structure. technique seems very efficient despite complex equipment.

Язык: Английский

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Bone preservation or augmentation simultaneous with or prior to dental implant placement: A systematic review of outcomes and outcome measures used in clinical trials in the last 10 years

Journal Of Clinical Periodontology, Год журнала: 2022, Номер 50(S25), С. 67 - 82

Опубликована: Июль 11, 2022

Abstract Aim To evaluate outcome measures and methods of assessment in clinical studies on bone augmentation/preservation procedures for the placement dental implants. Materials Methods A systematic search was performed three databases from January 2011 to April 2021 identify reporting any type procedure. The outcomes that have been used assess efficacy or performance each study were registered assigned different domains (group outcomes). review followed Preferred Reporting Items Systematic Review Meta‐Analyses statement. Results Seven‐hundred eighty‐three publications included. Only 81.8% papers had a clear definition their primary outcome. rate complications (59.3%), implant survival (58.2%), 3D radiographic gain/change (30%), marginal level (MBL; 29%), histological (25.5%) most frequently reported domains. commonly (25.8%), by (13.0%). Patient‐reported (PROMs) 15.7% studies. Differences observed among types preservation/augmentation interventions (i.e., alveolar ridge preservation, immediate implants, horizontal and/or vertical augmentation, sinus floor augmentation). Conclusion Within past decade, great heterogeneity considered evaluating procedures. Three‐dimensional routinely main variable, while PROMs rarely reported.

Язык: Английский

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Alveolar Ridge Preservation with Autologous Platelet-Rich Fibrin (PRF): Case Reports and the Rationale

Dentistry Journal, Год журнала: 2023, Номер 11(10), С. 244 - 244

Опубликована: Окт. 23, 2023

In dental implantology, alveolar ridge preservation (ARP) has emerged as a standard technique to address dimensional changes that affect morphology following tooth loss. Various alternative graft materials, including xenografts, alloplasts, and allografts, have been effectively employed in fresh extraction sites for ARP. Current evidence suggests these materials primarily serve bio-scaffolds, which are slowly incorporated, thus necessitating waiting period of at least 4–6 months before implant placement. Consequently, the ARP extends overall duration treatment by several months. Recently, incorporation form autologous platelet concentrate, known platelet-rich fibrin (PRF), advocated conjunction with method bioenhancement soft- hard-tissue healing regeneration. PRF contains platelet-derived growth factors, hormones, bioactive components like cytokines demonstrated ability stimulate angiogenesis tissue regeneration throughout all phases wound healing. Additionally, concentration leukocytes present matrix plays vital role part osteoimmune response. The reported advantages incorporating autogenous concentrates during encompass reduced time, improved bone regeneration, socket sealing through matrix, antibacterial properties, decreased post-extraction pain infection risk. Therefore, objective this paper is review existing regarding application extraction. Two clinical case studies presented, wherein was enhanced PRF, followed placement within relatively short 8 weeks. These cases further proof concept supporting adjuvant use enhance accelerate after

Язык: Английский

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The role and mechanism of platelet-rich fibrin in alveolar bone regeneration

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 168, С. 115795 - 115795

Опубликована: Ноя. 2, 2023

Platelet-rich fibrin (PRF), as an autologous blood preparation, has been receiving increasing attention in recent years and successfully applied various clinical treatments for alveolar bone regeneration the oral field. This review focuses on analyzing summarizing role mechanism of PRF regeneration. We first provide a brief introduction to PRF, then summarize mechanisms by which promotes from three aspects: osteogenesis mechanism, induction conduction involving multiple signaling pathways such Smad, ERK1/2, PI3K/Akt, Wnt/β-catenin. also explore roles scaffold, filler, combination with graft materials, detailing how provides wealth experimental evidence. Finally, we current applications fields. The is becoming increasingly important, its are more research understanding. article will reference significant value related exploration may lead discovery new therapeutic targets development effective efficient treatment strategies.

Язык: Английский

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Treatment of Odontogenic Maxillary Sinusitis with the Use of Growth Factors in Advanced Platelet-Rich Fibrin for Immediate Closure of Oro-Antral Communication: A Case Report

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4339 - 4339

Опубликована: Апрель 14, 2024

Chronic odontogenic maxillary sinusitis (COMS), a prolonged inflammation of the sinus lasting over 12 weeks, is often result periapical lesions, marginal periodontitis, and complications like oro-antral communication (OAC) fistula (OAF). OAC, commonly emerging post-teeth extraction in lateral maxilla, lacks documented treatments using advanced platelet-rich fibrin (A-PRF). This study evaluates A-PRF's efficacy treating COMS immediately sealing extensive OAC. A case 28-year-old male with linked to lesion supernumerary molars presented. Treatment involved extracting specific teeth while preserving adjacent ones A-PRF for immediate OAC closure. A-PRF, enriched growth factors, was pivotal healing, showcasing enhanced tissue regeneration, pain reduction, faster recovery. The findings suggest as an effective adjunct COMS, proposing its inclusion standard treatment protocols. underscores potential improving outcomes patients related complications.

Язык: Английский

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Human versus Rat PRF on Collagen Membranes: A Pilot Study of Mineralization in Rat Calvaria Defect Model

Bioengineering, Год журнала: 2024, Номер 11(5), С. 414 - 414

Опубликована: Апрель 23, 2024

Platelet-rich fibrin, the coagulated plasma fraction of blood, is commonly used to support natural healing in clinical applications. The rat calvaria defect a standardized model study bone regeneration. It remains, however, unclear if appropriate investigate impact human PRF (Platelet-Rich Fibrin) on To this end, we soaked Bio-Gide® collagen membranes or liquid concentrated before placing them onto 5 mm calvarial defects Sprague Dawley rats. Three weeks later, histology and micro-computed tomography (μCT) were performed. We observed that with show characteristic features new areas mineralized matrix, indicated by median volume 1.5 mm3 (range: 0.9; 5.3 mm3). Histology revealed growing underneath membrane hybrid where fibers are embedded bone. Moreover, passive mineralization observed. PRF, devoid histological formation center defect; only occasionally, formed at margins. Human (h-PRF) caused 0.9 0.3-3.3 mm3), which was significantly lower than what (r-PRF), BV 1.2 0.3-5.9 Our findings indicate suitable for assessing effects formation, but caution warranted when extrapolating conclusions regarding efficacy PRF.

Язык: Английский

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Healing of Extraction Sites after Alveolar Ridge Preservation Using Advanced Platelet-Rich Fibrin: A Retrospective Study

Bioengineering, Год журнала: 2024, Номер 11(6), С. 566 - 566

Опубликована: Июнь 3, 2024

Background: Over time, numerous surgical procedures and biomaterials have been proposed for the reconstruction of post-extraction bone defects, each with their advantages disadvantages. The main objective this study was to evaluate dimensional changes in alveolar 3 months after tooth extraction, before implant planning, comparing ridge preservation (ARP) spontaneous healing. Methods: A total 84 patients non-restorable molars were included study. Forty-two received ARP advanced platelet-rich fibrin (A-PRF) healing evaluated these patients. Cone beam computed tomography (CBCT) analysis performed intervention used determine vertical horizontal dimensions produced extraction. Results: CBCT measurements showed reduction both size groups. For group, parameters (height, width) higher compared control group. percentage variations between differences from two groups 38.58% height, width 36.88% at 0 mm, 35.56% 36.61% 5 38.73% 7 mm. statistically significant (p ˂ 0.0005). Conclusions: results obtained A-PRF a reduced loss volume

Язык: Английский

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