Commentary on the senate select committee into the provision of and access to dental services in Australia: an opportunity for reform

Australian Dental Journal, Год журнала: 2024, Номер 69(3), С. 162 - 174

Опубликована: Март 8, 2024

ABSTRACT A recent Senate Select Committee has tabled its report into the provision of and access to dental care in Australia. The heard: There are significant barriers for many people accessing care, including high costs, trauma fear, long waiting times inaccessible services. service gaps, a lack special needs dentists, limited mobile services, very few Aboriginal dentists sparse services regional areas. impacts poor oral health, pain suffering, shame low self‐esteem, nutrition poorer general health. benefits good ability smile, eat talk, improved confidence, increased productivity being more employable. were 35 recommendations reform centred around need put mouth back body covered by five broad themes: More equitable access. Better integration. National data coordination. Awareness education. Culturally safe accessible care. This paper provides an overview problem focuses on recommended funding reforms necessary improve

Язык: Английский

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Xenogenous implanted dental follicle stem cells promote periodontal regeneration through inducing the N2 phenotype of neutrophils

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 26, 2024

Periodontal tissue loss is the main reason for tooth mobility and caused by periodontal disease. Dental follicle stem cells (DFSCs) have significant therapeutic potential in regeneration, which maybe mainly depends on their potent immunomodulatory capacity. Consequently, this study aims to elucidate impact of implanted xenogenous DFSCs innate immune responses during early late stages defect repair period. To trace investigate immunomodulation mechanisms vivo, were engineered (E-DFSCs) using lentiviral vectors expressing CD63-enhanced green fluorescent protein (CD63-EGFP) β-Actin-mCherry (ACTB-mCherry) exhibit red fluorescence. The biological characteristics functions E-DFSCs verified proliferation, differentiation, co-culture experiments vitro. In regeneration capacity was detected implantation murine model, response at 1st, 3rd, 5th days (early stage) 4th week (late after implantation. vitro assessments showed that retain similar properties non-engineered counterparts but enhanced macrophage capability. mice models, four-week micro-CT histological evaluations indicated equivalent efficiency regeneration. At stage defect, fluorescence tracking might primarily activate endogenous through direct contact indirect actions, most these are myeloperoxidase-positive neutrophils. Additionally, compared with control group, neutrophilic infiltration conversion N2-type significantly increased E-DFSC group. more M2-type macrophages, fewer TRAP + osteoclasts, an upregulated OPG/RANKL ratio group balance tilts towards healing bone formation. can induce N2 phenotype neutrophils stage, mechanism host promote

Язык: Английский

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Albumin nanoparticles are a promising drug delivery system in dentistry

BioMedical Engineering OnLine, Год журнала: 2024, Номер 23(1)

Опубликована: Ноя. 27, 2024

Periodontal infection is a long-lasting inflammatory condition caused by the growth and development of an abnormal harmful community microorganisms. This destructive illness leads to loss tissues that support teeth, degradation bone surrounding eventually tooth loss. To treat oral infections, it necessary use nonsurgical methods such as antibiotics. However, indiscriminate incorrect antibiotics results in drug resistance. Among these alternate therapeutic options, using nanoparticles infectious dental disease was particularly significant. Consequently, researchers have worked develop effective satisfactory delivery method for treating periodontal illnesses. Albumin serve considerable function carriers chemical biomolecular medications, anticancer treatments; they several advantages, including biocompatibility biodegradability, are well-tolerated with no adverse effects. benefits over other nanomaterials. Protein nanocarriers provide advantages biocompatibility, reduced immunogenicity, lower cytotoxicity. Furthermore, this nanoparticle demonstrated significant intrinsic antibacterial properties without being loaded antibiotic medicines. As medication method, albumin substantial applications disorders infection, apical periodontitis, peri-implantitis. result, article, we studied usage disorders.

Язык: Английский

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The Effect of Non-Surgical Periodontal Treatment on Patients with Combined Refractory Arterial Hypertension and Stage III, Grade B Periodontitis: A Preliminary Prospective Clinical Study

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(13), С. 4277 - 4277

Опубликована: Июнь 26, 2023

We sought to evaluate the effects of non-surgical periodontal treatment (NSPT) on clinical parameters, systemic blood pressure (BP), and plasma levels inflammation markers in patients with combined refractory arterial hypertension (RAH) stage III grade B periodontitis. Twenty-seven participants RAH periodontitis received NSPT. The analyzed parameters were probing depth (PD), attachment level (CAL), bleeding (BOP), plaque index (PI). An assessment was performed for BP, complete count, coagulogram, creatinine measurement, C-reactive protein (CRP), glycated hemoglobin, cholesterol, glutamic oxaloacetic transaminase, glutamate pyruvic waist–hip ratio, body mass index. In follow-up period, twenty-two evaluated at baseline after 90 180 days. data submitted statistical analysis (α = 0.05%). As expected, results showed a significant improvement percentages PI, BOP, PD, CAL, which statistically days (p < 0.0001). Importantly, NSPT significantly reduced CRP 0.02). However, no reduction BP noted periods. NSPT, despite benefits but not

Язык: Английский

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Prediabetes Associates with Matrix Metalloproteinase-8 Activation and Contributes to the Rapid Destruction of Periodontal Tissues

European Journal of Dentistry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Abstract Objective The aim of this cross-sectional study was to investigate the relationship between periodontitis, potential periodontitis oral fluid biomarkers, and prediabetes. Materials Methods This included 150 Greek adults aged 25 78 years who were tested with an Hemoglobin A1C (HBA1c) diagnostic system, active-matrix metalloproteinase-8 (aMMP-8) point-of-care (PoC) test, several salivary biomarkers enzyme-linked immunosorbent assay tests gelatin zymography. A full-mouth clinical examination performed assess their periodontal health status. Statistical Analysis Kruskal–Wallis test used determine statistically significant difference in levels different stages, grades, stages grades combined. Spearman's rank correlation strength direction association aMMP-8 HbA1c (<5.7 ≥5.7%) other among patients severe periodontitis. two-sided p-value below 0.05 considered study. Results aMMP-8, but not total MMP-8 or associated significantly stage grade combined (p < 0.001, test). Among III C patients, positively correlated prediabetes (Spearman's rho = 0.646, p 0.044), (rho 0.636, 0.048), PMN Elastase 0.729, 0.017), MMP-9 0.721, 0.019), MMP-8/TIMP-1 molar ratio 0.879, 0.001). Conclusion Prediabetic disease development can upregulate expression (total MMP-8) rapidly progressing, where latent species are further activated into active forms (aMMP-8). Simultaneously, proinflammatory biomarker elevated tissue-destructive cascade. is easily detectable online/in real-time within 5 minutes by PoC testing at dentist's office.

Язык: Английский

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