Impact of keratinized mucosa on implant‐health related parameters: A 10‐year prospective re‐analysis study

Clinical Implant Dentistry and Related Research, Год журнала: 2024, Номер 26(3), С. 554 - 563

Опубликована: Фев. 28, 2024

Abstract Aim To investigate whether the lack of keratinized mucosa (KM) affects peri‐implant health after 10 years loading. Materials and Methods Data from 74 patients with 148 implants two randomized controlled studies comparing different implant systems were included analyzed. Clinical parameters including bleeding on probing (BOP), depth (PD), plaque index, marginal bone loss (MBL), KM width (KMW) at buccal sites collected baseline (time final prosthesis insertion), 5‐year postloading. Multivariable logistic linear regression models by means a generalized estimated equation (GEE) used to evaluate influence clinical parameters; BOP, MBL, PD, adjusted for type (one‐piece or two‐piece) compliance. Results A total 35 (24.8%) healthy, 67 (47.5%) had mucositis 39 (27.6%) affected peri‐implantitis. In absence (KM = 0 mm), 75% exhibited mucositis, while in presence (KMW >0 mm) 41.2% mucositis. Regarding peri‐implantitis, corresponding percentages 20% 26.7% mm). Unadjusted showed that tended reduce odds showing BOP (OR: 0.28 [95% CI, 0.07 1.09], p 0.06). The model revealed having 0.21 0.05 0.85], 0.02) using two‐piece 0.34 0.15 0.75], 0.008) significantly reduced BOP. Adjusted GEE associated MBL changes ( < 0.05). Conclusion appears be linked such as but association is weak. design one‐piece may account their increased exhibiting

Язык: Английский

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Periodontal Endoscopy for Mechanical Debridement in the Non-Surgical Management of Peri-Implantitis: A Narrative Review

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 346 - 346

Опубликована: Янв. 8, 2025

Background: The aim of the present narrative review is to synthesize available scientific evidence on effects submarginal instrumentation with periodontal endoscopy and evaluate its' potential efficacy in terms non-surgical therapy peri-implantitis. Methods: literature search was performed via electronic databases, including PubMed, Web Science, Cochrane, Scopus, supplemented by manual searching. A conducted addressing following PICOS questions: (1) What implant surface aid a endoscope patients peri-implantitis? (2) subgingival compared conventional periodontitis, clinical parameters patient-reported outcomes? Mechanical decontamination crucial for resolving inflammation arresting further bone loss. However, there no consensus most effective treatment. Non-surgical remains initial intervention, focused biofilm removal control disease, although limited capability achieve complete disease resolution as presence threads complex-structured hinder removal. This evokes need providing supporting technologies such endoscopy, which enables direct visualization precision, potentially enhancing outcomes reducing necessity surgical procedures their associated risks. Within limitations this review, may offer less tissue-invasive approach. Larger prospective studies RCTs are needed confirm these findings guide clinicians determining endoscopy's suitability based specific case characteristics.

Язык: Английский

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Nano Sim@ZIF8@PDA modified injectable temperature sensitive nanocomposite hydrogel for photothermal/drug therapy for peri-implantitis

Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123327 - 123327

Опубликована: Янв. 1, 2025

Язык: Английский

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Treatment Options for the Management of the Postextraction Socket: Report From the First Giuseppe Cardaropoli Foundation Consensus Conference

Journal of Periodontal Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

ABSTRACT Aim Different approaches have been proposed for implant placement following tooth extraction. A Consensus conference was organised to provide expert‐based recommendations the treatment of postextraction site in aesthetic zone conjunction with therapy. Methods panel eight experts a documented longstanding clinical and research experience field therapy were invited participate structured survey. Participants asked select their preferred approach different scenarios from list options. Results summarised discussed person at 2 day consensus conference. Based on outcome, phrased are reported here. The group agreed that case an intact alveolus, immediate prosthetics represents reference choice if proper primary stability can be achieved buccal bone plate is present. bone‐to‐implant gap more than mm should seeked grafted. Alveolar ridge preservation early contour augmentation may represent alternative. If alveolus compromised, staged (early or delayed placement) preferred. Conclusions characteristics site, terms available volume, integrity periodontal phenotype determining factors therapeutic choice. Therefore, selection based well‐defined criteria extremely important adequate way guide clinician choosing most appropriate management timing placement.

Язык: Английский

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A versatile nanoplatform with excellent biofilm permeability and spatiotemporal ROS regulation for peri-implantitis treatment

Theranostics, Год журнала: 2025, Номер 15(8), С. 3490 - 3516

Опубликована: Фев. 24, 2025

Rationale: Dental implant restoration is essential for rehabilitating dentition defects. However, peri-implantitis (PI) seriously threatens the long-term stability of implants. Treating PI requires complete eradication plaque biofilm and meticulous modulation inflammatory responses. Antibacterial photodynamic therapy (aPDT) presents a promising potential in antibacterial realm. Nonetheless, traditional aPDT faces challenges such as inadequate penetration distribution photosensitizers, well lack precise bacteria targeting. Moreover, excessive ROS generated by will aggravate oxidative stress peri-implant tissues, this issue cannot be neglected. Methods: The CuTA-Por@ε-PL nanoplatforms (CPP NPs) were synthesized characterized using dynamic light scattering, transmission electron microscopy, dye probes detail. anti-inflammatory activities CPP NPs evaluated both vitro vivo. vivo therapeutic efficacy was successively analyzed through micro-CT, hematoxylin eosin staining, Masson's immunofluorescence colony formation units (CFU), among other techniques. Results: Porphyrin (Por), CuTA nanozyme with SOD/CAT activities, ε-Polylysine (ε-PL) combined to fabricate via straightforward approach. notable positive charge facilitated penetration, Then, irradiation 660 nm laser triggered burst elimination. After aPDT, scavenged residual modulated host immunity regulating macrophage polarization. As result, CPP-treated groups demonstrated most outstanding performance rat model. Conclusions: Given pathogenesis PI, strategy rationally designed multifunctional NP functions spatiotemporal regulation. It provides potentially novel approach treatment, which may have profound impact on improving prognosis patients advancing field dentistry.

Язык: Английский

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The Role of Photodynamic Therapy Mediated by Natural Photosensitisers in the Management of Peri-Implantitis: A Systematic Review

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 443 - 443

Опубликована: Март 30, 2025

Background: Peri-implantitis, an inflammatory condition leading to progressive bone loss around dental implants, represents a significant challenge in modern implant dentistry. Conventional mechanical debridement and adjunctive antibiotics or antiseptics often fail fully eradicate complex biofilms may promote antibiotic resistance. Photodynamic therapy (PDT) mediated by natural photosensitizers (e.g., curcumin, riboflavin, 5-aminolevulinic acid) has emerged as potential strategy for peri-implantitis management due its targeted antimicrobial anti-inflammatory effects. Objectives: This systematic review aimed evaluate the efficacy, clinical outcomes, safety of PDT treatment identify optimal protocols regarding photosensitizer concentrations, light source parameters, application techniques. Methods: Following PRISMA 2020 guidelines, databases (PubMed/Medline, Embase, Scopus, Cochrane Library) were searched from 1 January 2015 3 2025 English-language publications. Studies assessing naturally based interventions vitro diseased surfaces included. Quality assessment used Revised Risk Bias tool (RoB 2) randomized controlled trials tailored nine-item framework studies. Eleven studies met inclusion criteria. Results: Despite heterogeneity methodologies, especially wavelengths, energy densities, formulations, most reported notable reductions bacterial viability, biofilm mass, indices (probing depth bleeding on probing). Curcumin riboflavin frequently demonstrated comparable efficacy standard disinfectants, while acid (5-ALA)-based also showed promising microbiological improvements. However, complete eradication was rarely achieved. Conclusions: Natural-photosensitizer-based appears be valuable adjunct peri-implantitis, enhancing microbial control outcomes. Standardization further well-designed with extended follow-up periods are warranted confirm long-term inform evidence-based guidelines.

Язык: Английский

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Improved positional accuracy of dental implant placement using a haptic and machine‐vision‐controlled collaborative surgery robot: A pilot randomized controlled trial

Journal Of Clinical Periodontology, Год журнала: 2023, Номер 51(1), С. 24 - 32

Опубликована: Окт. 23, 2023

Abstract Aim To compare the implant accuracy, safety and morbidity between robot‐assisted freehand dental placement. Materials Methods Subjects requiring single‐site placement were recruited. Patients randomly allocated to Differences in positional accuracy of implant, surgical complications assessed. The significance intergroup differences was tested with an intention‐to‐treat analysis a per‐protocol (PP) (excluding one patient due calibration error). Results Twenty patients (with median age 37, 13 female) included. One subject assigned robotic arm excluded from PP because large error dislodgement index. For placement, analysis, (25th–75th percentile) platform global deviation, apex deviation angular 1.23 (0.9–1.4) mm/1.9 (1.2–2.3) mm ( p = .03, Mann–Whitney U ‐test), 1.40 (1.1–1.6) mm/2.1 (1.7–3.9) < .01) 3.0 (0.9–6.0)°/6.7 (2.2–13.9)° .08), respectively. Both methods showed limited damage alveolar ridge had similar peri‐ post‐operative safety. Conclusions Robot‐assisted enabled greater compared this pilot trial. system should be further developed simplify procedures improve validated properly sized trials assessing full spectrum relevant outcomes.

Язык: Английский

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Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri-implant diseases

Cochrane library, Год журнала: 2024, Номер 2024(8)

Опубликована: Июль 12, 2024

Язык: Английский

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A Mapping Review of the Pathogenesis of Peri-Implantitis: The Biofilm-Mediated Inflammation and Bone Dysregulation (BIND) Hypothesis

Cells, Год журнала: 2024, Номер 13(4), С. 315 - 315

Опубликована: Фев. 8, 2024

This mapping review highlights the need for a new paradigm in understanding of peri-implantitis pathogenesis. The biofilm-mediated inflammation and bone dysregulation (BIND) hypothesis is proposed, focusing on relationship between biofilm, inflammation, biology. close interactions immune cells are discussed, with multiple stable states likely existing clinically observable definitions peri-implant health peri-implantitis. framework presented aims to explain transition from disease as staged incremental process, where factors contribute distinct steps towards tipping point manifested clinically. These might be reached different ways patients may constitute highly individualised paths. Notably, affecting underlying biology identified pathogenesis peri-implantitis, highlighting that disruptions host–microbe homeostasis at implant–mucosa interface not sole factor. An improved will allow intervention levels personalised treatment approach. Further research areas identified, such use novel biomarkers detect changes macrophage polarisation activation status, turnover.

Язык: Английский

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Maintenance of peri-implant health in general dental practice

BDJ, Год журнала: 2024, Номер 236(10), С. 781 - 789

Опубликована: Май 24, 2024

Abstract The long-term maintenance or restoration of peri-implant tissues‘ health depends on the strategic implementation preventive measures and interventions. These should be initiated before implant placement continued throughout a patient's lifetime, as part tailored comprehensive supportive care (SPIC) programme. Central to clinical efforts maintaining rehabilitating tissues are several key factors, including ongoing assessment frequent monitoring tissue stability, proactive oral promotion, control risk factors indicators provision professional plaque biofilm removal. It is paramount importance underline that SPIC not limit its scope exclusively patients already in state health; fact, it imperative extend protective effect individuals who have been previously diagnosed treated for diseases, focusing preventing recurrence progression, thereby avoiding further complications, such loss. This narrative review presents an overview current literature steps providing insights into critical considered when managing dental general practice.

Язык: Английский

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