Immunopathogenesis and immunotherapy of diabetes-associated periodontitis
Clinical Oral Investigations,
Год журнала:
2025,
Номер
29(1)
Опубликована: Янв. 4, 2025
Язык: Английский
Convertible Hydrogel Injection Sequentially Regulates Diabetic Periodontitis
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Diabetes
exacerbates
periodontitis
by
overexpressing
reactive
oxygen
species
(ROS),
which
leads
to
periodontal
bone
resorption.
Consequently,
it
is
imperative
relieve
inflammation
and
promote
alveolar
regeneration
comprehensively
for
the
development
of
diabetic
treatment
strategies.
Furthermore,
an
orderly
avoid
interference
between
these
two
processes
can
achieve
optimal
therapeutic
effect.
Thus,
we
constructed
a
sequential
sustained
release
system
based
on
zeolitic
imidazolate
framework-8
(ZIF-8)-modified
chitosan
thermosensitive
hydrogel
(TOOTH)
therapy
in
this
work.
Chemically
modified
tetracycline-3
(CMT-3)
platelet-derived
growth
factor-BB
(PDGF-BB)
were
loaded
ZIF-8
release,
respectively,
with
aim
reducing
facilitating
tissue
regeneration.
During
therapy,
CMT-3
first
escaped
from
due
degradation
diffusion
ROS
elimination.
Subsequently,
was
dissociated
under
acid
microenvironment,
PDGF-BB
sustainably
released
osteogenesis.
The
intervals
could
be
regulated
sizes
ZIF-8.
biocompatible
TOOTH
exhibited
favorable
effect
vitro
vivo.
sequentially
controlled
facilitated
holds
promise
promoting
offers
potential
clinical
translation.
Язык: Английский
Effect of Periodontal Treatment in Patients with Periodontitis and Diabetes: Review of Systematic Reviews with Meta-Analyses in the Last Five Years
Healthcare,
Год журнала:
2024,
Номер
12(18), С. 1844 - 1844
Опубликована: Сен. 14, 2024
Background:
Periodontitis
is
a
chronic
infectious–inflammatory
pathology,
with
high
prevalence,
which
destroys
the
dental
support
and,
if
left
untreated,
leads
to
tooth
loss.
It
associated
other
pathologies,
particularly
diabetes
mellitus.
Objectives:
Our
objective
was
conduct
review
of
systematic
reviews
meta-analyses
determine
evidence
for
periodontal
treatment
on
periodontitis
and
diabetes.
Second,
we
assessed
risk
bias
methodological
quality
using
AMSTAR-2
ROBIS
tools.
Methods:
We
performed
bibliographic
searches
in
PubMed/Medline,
Embase,
Cochrane
Central,
Dentistry
&
Oral
Sciences
Source
databases
Web
Science
(WOS)
scientific
information
service
identify
from
last
five
years.
Results:
Eighteen
studies
that
met
inclusion
criteria
evaluated
16,247
subjects
were
included.
The
most
studied
parameters
probing
pocket
depth,
clinical
attachment
level,
bleeding
glycated
hemoglobin.
Most
included
adult
patients
type
2
mellitus
(T2DM).
considered
by
showed
significant
errors.
domain
worst
assessment
tool.
Conclusions:
Despite
weaknesses
terms
bias,
DM
appear
contribute
improved
outcomes
bidirectional
manner
between
DM.
Язык: Английский
Efficiency of periodontal treatment to improve type 2 diabetes mellitus outcomes: A systematic review and meta‐analysis of economic evaluations
Community Dentistry And Oral Epidemiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 16, 2024
Abstract
Background
To
assess
the
efficiency
of
periodontal
treatment
(PT)
in
improving
diabetes‐related
outcomes
adults
with
type
2
diabetes
mellitus
(T2DM)
and
periodontitis,
providing
an
updated
comprehensive
synthesis
from
economic
evaluations
(EE).
Methods
Seven
databases
one
register
were
independently
searched
by
two
reviewers
for
articles
published
up
to
8
May
2024.
Studies
that
assessed
PT
versus
no
or
other
dental
treatments
included.
Risk
bias
was
using
Cochrane
RoB
2,
ROBINS‐I
ECOBIAS
tools
first
stage
EE
CHEERS
checklist
NICE
quality
appraisal
tool
overall
EE.
Qualitative
quantitative
syntheses
conducted
GRADE
approach.
Results
Eleven
studies
reduces
total
healthcare
costs,
including
inpatient
outpatient,
costs
drug
(low
moderate
certainty).
A
incremental
net
benefit
USD
12
348
(2022
currency,
95%
CI
195–12
500)
estimated
three
high‐quality
model‐based
cost‐utility
analyses
(high
Discussion
The
inclusion
patients
T2DM
periodontitis
is
cost‐effective.
Future
research
required
ensure
transferability
these
findings
inform
decision
makers
different
countries.
Registration
PROSPERO
CRD42023443146.
Язык: Английский
A Three-Month Clinical Trial on the Efficacy of Hyaluronic Acid Adjunctive Non-Surgical Therapy for Periodontitis in Patients with Type 2 Diabetes Mellitus
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2516 - 2516
Опубликована: Ноя. 4, 2024
Background/Objectives:
Conventional
periodontal
treatment
for
patients
with
diabetes
has
shown
promising
results,
primarily
focusing
on
glycated
hemoglobin
(HbA1c)
levels
as
an
endpoint
measure.
The
properties
of
hyaluronic
acid
(HA)
have
been
harnessed
in
various
therapies,
and
it
is
a
agent
also
non-surgical
approach.
aim
this
clinical
trial
was
to
assess
the
efficacy
local
adjunctive
periodontitis
type
2
diabetes.
Methods:
Eighty
adult
participants
well-controlled
(HbA1c
7%
(53
mmol/mol)
or
less)
took
part
trial.
parameters
well
were
evaluated,
analysis
potential
differences
between
control
(placebo)
intervention
groups
performed.
Results/Conclusions:
A
decrease
all
values
after
observed
vast
majority
both
groups.
Differences
12
weeks
placebo
HA
therapy
Bleeding
probing
(BoP)
reduced
group
15–25%
approximately
5.5%
more
(9.5–18.25%).
attachment
level
(CAL)
decreased
1
mm
(1–2
mm)
than
no
(2–3
mm).
depth
(PD)
similarly
(3–3.75
Due
bilateral
relationship
periodontitis,
healthcare
professionals
seek
advancements
managing
inflammation.
results
study
indicate
that
worth
considering
Язык: Английский