Air Pollution and Oral Health: An Overall Insight From Genetic Causality

International Dental Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

A growing body of epidemiological data consistently links air pollution to various adverse health outcomes. However, the potential connection between and risk oral diseases remains underexplored. This study utilized a two-sample Mendelian randomization approach assess causal relationship diseases. Six categories were considered as exposures: nitrogen oxides (NOx), dioxide (NO2), particulate matter (PM2.5, PM2.5-10, PM10), PM2.5 absorbance. The outcomes included 18 health-related drawn from Finngen R10 dataset, Gene-Lifestyle Interactions in Dental Endpoints consortium, Oncoarray cavity oropharyngeal cancer consortium. Sensitivity analyses performed validate primary inverse-variance weighted estimates using methods such median, mode, MR Egger. analysis demonstrated detrimental effect on multiple conditions, yielding 5 positive associations including with leukoplakia, gingivitis periodontitis; PM2.5-10 pulp periapical diseases, NO2 periodontitis, cavity, salivary glands jaws tests showed no evidence heterogeneity or pleiotropy, affirming robustness findings. highlights impact health, emphasizing need for further research into underlying mechanisms interactions. These findings reinforce importance implementing environmental interventions mitigate associated risks health.

Язык: Английский

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Research on the Impact of Urban Built Environments on PM2.5 Pollution Based on Machine Learning Methods

Atmospheric Pollution Research, Год журнала: 2025, Номер unknown, С. 102503 - 102503

Опубликована: Март 1, 2025

Язык: Английский

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J‐shaped associations between thiocyanate and periodontitis: A cross‐sectional study from NHANES 2009–2014

Journal of Periodontology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 20, 2025

Abstract Background This study aims to assess the associations between exposures thiocyanate and risk of periodontitis among US adults. Methods We conducted a cross‐sectional using data from National Health Nutrition Examination Survey (NHANES) 2009–2014. categorized according 2017 classification scheme. Restricted cubic spline analysis weighted multivariable logistic regression were employed examine relationship exposure periodontitis. Results A total 3319 participants included in our study. observed J‐shaped association periodontitis, with an inflection point at 3.32. Before point, we noted negative trend (odds ratio [OR] = 0.89, 95% CI: 0.73–1.08), particularly smokers (OR 0.31, 0.08–1.18). After found positive 1.21, 1.03–1.42), non‐obese individuals 1.42, 1.16–1.75) non‐hypertensive 1.34, 1.12–1.61). Conclusion exists indicating its complex role, further prospective trials are necessary confirm these findings. Plain language summary Thiocyanate, compound prevalent both environment dietary sources, can impact health through mechanisms that either protective or detrimental. sought investigate specific utilizing (NHANES). The findings reveal insufficient excessive levels linked increased underscoring critical importance maintaining optimal range for periodontal health.

Язык: Английский

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Particulate Matter 2.5 and Severe Periodontitis Among Colombian Adults

Journal of Periodontal Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

The primary aim was to determine the association between particulate matter 2.5 (PM

Язык: Английский

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