Periodontal diseases, potential mediators and development of liver fat content: a community-based large cohort DOI Creative Commons

Bofu Liu,

Yu Jia,

Zhuo-Jun Gu

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 9, 2025

A high level of liver fat content (LFC) is a key indicator steatotic disease (SLD), reflecting its pathological essence. Periodontal (PD) recognized as chronic inflammatory condition and cause widespread adverse health impact. This study aims to investigate the relationship between PD LFC development. In UK Biobank, were gathered through digital questionnaire, including gum pain, bleed, or teeth loose. was measured by Fatty Liver Index (>60 indicates SLD) in cross-sectional analysis magnetic resonance imaging (quantified Proton Density Fat Fraction, PDFF) longitudinal analysis. Multivariable logistic linear regression models conducted association LFC. analysis, 164,150 (37.4%) individuals diagnosed with SLD, showed significant SLD (odds ratio: 1.104, 95% CI: 1.075-1.132). prospective total 39,656 participants median follow-up 10.3 years included. an arithmetic mean difference 0.091 PDFF (95% 0.047-0.139), males exhibiting stronger than females (P for interaction <0.05). Significant mediating effects observed body mass index (19.58%), C-reactive protein (11.61%), blood glucose (6.70%), healthy diet score (5.99%) all <0.001). There pronounced correlation LFC, predominantly driving this link. may be partially mediated fat, inflammation, dietary habit, insulin resistance.

Язык: Английский

Genetic risk factors for periodontitis: a genome-wide association study using UK Biobank data DOI Creative Commons
Chenyi Gao, Mark M. Iles, D. Timothy Bishop

и другие.

Clinical Oral Investigations, Год журнала: 2025, Номер 29(2)

Опубликована: Фев. 14, 2025

Язык: Английский

Процитировано

0
Periodontal diseases, potential mediators and development of liver fat content: a community-based large cohort DOI Creative Commons

Bofu Liu,

Yu Jia,

Zhuo-Jun Gu

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 9, 2025

A high level of liver fat content (LFC) is a key indicator steatotic disease (SLD), reflecting its pathological essence. Periodontal (PD) recognized as chronic inflammatory condition and cause widespread adverse health impact. This study aims to investigate the relationship between PD LFC development. In UK Biobank, were gathered through digital questionnaire, including gum pain, bleed, or teeth loose. was measured by Fatty Liver Index (>60 indicates SLD) in cross-sectional analysis magnetic resonance imaging (quantified Proton Density Fat Fraction, PDFF) longitudinal analysis. Multivariable logistic linear regression models conducted association LFC. analysis, 164,150 (37.4%) individuals diagnosed with SLD, showed significant SLD (odds ratio: 1.104, 95% CI: 1.075-1.132). prospective total 39,656 participants median follow-up 10.3 years included. an arithmetic mean difference 0.091 PDFF (95% 0.047-0.139), males exhibiting stronger than females (P for interaction <0.05). Significant mediating effects observed body mass index (19.58%), C-reactive protein (11.61%), blood glucose (6.70%), healthy diet score (5.99%) all <0.001). There pronounced correlation LFC, predominantly driving this link. may be partially mediated fat, inflammation, dietary habit, insulin resistance.

Язык: Английский

Процитировано

0